Results 41 to 50 of about 2,604,284 (151)

Near-Infrared Photoimmunotherapy for Treatment of Colorectal Cancer in Orthotopic Nude-Mouse Models

, 2020
Background: Photoimmunotherapy (PIT) employs the use of near-infrared (NIR) laser to activate an antibody conjugated to a NIR-activatable dye to promote cancer cell death. PIT has shown to be effective in a number of studies, however, there is no data on
Filemoni Filemoni (8649674), Michael Bouvet (8649681), Siamak Amirfakhri (8649675), Paul Yazaki (8649684), Robert M. Hoffman (8649682), Justin Molnar (8649678), Hannah Hollandsworth (8276115)   +6 more
core   +1 more source

Antibody Drug Conjugates of Near-Infrared Photoimmunotherapy (NIR-PIT) in Breast Cancers

Technology in Cancer Research & Treatment, 2023
Worldwide, the incidence rate of breast cancer is the highest in women. Approximately 2.3 million people were newly diagnosed and 0.685 million were dead of breast cancer in 2020, which continues to grow.
Yingshu Cui BD, Yuanyuan Xu BD, Yi Li BD, Yuanyuan Sun BD, Jia Hu MD, Jia Jia BD, Xiaosong Li MD   +6 more
doaj   +1 more source

Recent Advances in Localized Immunomodulation Technology: Application of NIR-PIT toward Clinical Control of the Local Immune System

Pharmaceutics, 2023
Current immunotherapies aim to modulate the balance among different immune cell populations, thereby controlling immune reactions. However, they often cause immune overactivation or over-suppression, which makes them difficult to control.
Mizuki Yamada, Kohei Matsuoka, Mitsuo Sato, Kazuhide Sato   +3 more
doaj   +1 more source

Immediate in vivo target-specific cancer cell death after near infrared photoimmunotherapy

BMC Cancer, 2012
Background Near infrared (NIR) photoimmunotherapy (PIT) is a new type of cancer treatment based on a monoclonal antibody (mAb)-NIR phthalocyanine dye, (IR700) conjugate.
Mitsunaga Makoto, Nakajima Takahito, Sano Kohei, Kramer-Marek Gabriela, Choyke Peter L, Kobayashi Hisataka   +5 more
doaj   +1 more source

Disialoganglioside GD2-Targeted Near-Infrared Photoimmunotherapy (NIR-PIT) in Tumors of Neuroectodermal Origin

Pharmaceutics, 2022
Disialoganglioside (GD2) is a subtype of glycolipids that is highly expressed in tumors of neuroectodermal origins, such as neuroblastoma and osteosarcoma.
Fuyuki F. Inagaki, Takuya Kato, Aki Furusawa, Ryuhei Okada, Hiroaki Wakiyama, Hideyuki Furumoto, Shuhei Okuyama, Peter L. Choyke, Hisataka Kobayashi   +8 more
doaj   +1 more source

Unlocking Long‐Lived Charge‐Separated State in Pentamethine Cyanine Based on Anionic Hofmeister Effect for Photodynamic Immunotherapy

Advanced Science, EarlyView.
Based on the anionic Hofmeister effect, a universal strategy of incorporation of stereo‐π anion BPh4− into a series of Cy5 skeletons to unlock long‐lived charge‐separated states was reported, wherein the weak electronic coupling and low charge recombination driving force hinder the charge recombination process, elevating the oxygen‐independent ROS ...
Xuan Zhao, Lei Jiang, Yingyong Ni, Ting Wang, Junjun Wang, Shengyu Shi, Jianhua Yu, Zhou Lu, Xiaojiao Zhu, Hongping Zhou   +9 more
wiley   +1 more source

Wound healing after excision of subcutaneous tumors treated with near‐infrared photoimmunotherapy

Cancer Medicine, 2020
Near‐infrared photoimmunotherapy (NIR‐PIT) is a novel cancer therapy that employs a combination of infrared light and tumor‐targeted monoclonal antibody‐photoabsorber conjugates to cause both direct tumor necrosis and immunogenic cell death.
Adrian Rosenberg, Fuyuki Inagaki, Takuya Kato, Ryuhei Okada, Hiroaki Wakiyama, Aki Furusawa, Peter L. Choyke, Hisataka Kobayashi   +7 more
doaj   +1 more source

HER2 targeting near‐infrared photoimmunotherapy for a CDDP‐resistant small‐cell lung cancer

Cancer Medicine, 2021
Background Human epidermal growth factor receptor 2 (HER2) is tyrosine kinase receptor that belongs to the ErbB family and is overexpressed on the membrane surface of various cancer cells, including small cell lung cancer (SCLC); however, no HER2 ...
Kazuomi Takahashi, Shunichi Taki, Hirotoshi Yasui, Yuko Nishinaga, Yoshitaka Isobe, Toshinori Matsui, Misae Shimizu, Chiaki Koike, Kazuhide Sato   +8 more
doaj   +1 more source

Endoscopic Applications of Near-Infrared Photoimmunotherapy (NIR-PIT) in Cancers of the Digestive and Respiratory Tracts

Biomedicines, 2022
Near-infrared photoimmunotherapy (NIR-PIT) is a newly developed and promising therapy that specifically destroys target cells by irradiating antibody-photo-absorber conjugates (APCs) with NIR light.
Hideyuki Furumoto, Takuya Kato, Hiroaki Wakiyama, Aki Furusawa, Peter L. Choyke, Hisataka Kobayashi   +5 more
doaj   +1 more source

Photo‐responsive carbon dots for pyroptosis‐mediated anti‐tumor application

Responsive Materials, EarlyView.
Photo‐responsive CDs generate ROS to induce tumor cell pyroptosis, thereby stimulating antitumor immunity. Abstract Pyroptosis refers to a kind of lytic programmed cell death, characterized by the release of pro‐inflammatory cytokines during the process. Owing to its immune response stimulation ability, pyroptosis has garnered considerable attention in
Lingyun Li, Xue Wu, Zekun Yan, Jun Wu, Caishi Huang, Songnan Qu   +5 more
wiley   +1 more source