Results 41 to 50 of about 2,604,331 (176)

Intratumoral IL15 Improves Efficacy of Near-Infrared Photoimmunotherapy. [PDF]

Mol Cancer Ther, 2023
Abstract IL15 is a potent inducer of differentiation and proliferation of CD8+ T and natural killer (NK) cells, making it a promising candidate for cancer immunotherapy. However, limited efficacy of systemic monotherapy utilizing intravenous IL15 suggests the needs for alternative routes of administration or combination treatment with
Fukushima H, Furusawa A, Kato T, Wakiyama H, Takao S, Okuyama S, Choyke PL, Kobayashi H.   +7 more
europepmc   +3 more sources

Near infrared photoimmunotherapy of B‐cell lymphoma [PDF]

Molecular Oncology, 2016
AbstractNear infrared photoimmunotherapy (NIR‐PIT) is a new, highly‐selective cancer theranostics that employs an antibody‐photo absorber conjugate (APC). NIR‐PIT has successfully treated preclinical tumor models with APCs and is now in the first‐in‐human phase 1 clinical trial for head and neck cancer patients against EGFR. CD20 is highly expressed in
Tadanobu, Nagaya, Yuko, Nakamura, Kazuhide, Sato, Toshiko, Harada, Peter L, Choyke, Hisataka, Kobayashi   +5 more
openaire   +2 more sources

Trastuzumab‐based near‐infrared photoimmunotherapy in xenograft mouse of breast cancer

Cancer Medicine, 2023
Near‐infrared photoimmunotherapy (NIR‐PIT) is a novel form of cancer treatment using conjugates of antibody against overexpressed antigens in cancers and photoabsorber IRDye700DX.
Susumu Yamashita, Miho Kojima, Nobuhiko Onda, Toshinori Yoshida, Makoto Shibutani   +4 more
doaj   +1 more source

Near-infrared photoimmunotherapy (NIR-PIT) of bone metastases

Biomedicine & Pharmacotherapy, 2023
The bones are a common site for metastasis arising from solid tumors such as breast and prostate cancer. Chemotherapy, including immunotherapy, is rarely curative. Radiotherapy with pain palliation can temporize bone metastases but is generally considered a short-term solution and retreatment is difficult. Surgery is often necessary, yet recovery times
Fuyuki F, Inagaki, Hiroaki, Wakiyama, Aki, Furusawa, Ryuhei, Okada, Takuya, Kato, Daiki, Fujimura, Shuhei, Okuyama, Hiroshi, Fukushima, Seiichiro, Takao, Peter L, Choyke, Hisataka, Kobayashi   +10 more
openaire   +2 more sources

The use of near infrared (NIR) spectroscopy to improve soil mapping at the farm scale [PDF]

, 2008
The creation of fine resolution soil maps is hampered by the increasing costs associated with conventional laboratory analyses of soil. In this study, near infrared (NIR) reflectance spectroscopy was used to reduce the number of conventional soil ...
Söderström, Mats, Stenberg, Bo, Wetterlind, Johanna   +2 more
core   +2 more sources

Validation of the near infrared spectroscopy method for determining soil organic carbon by employing a proficiency assay for fertility laboratories [PDF]

, 2021
Current research indicates that near infrared (NIR) spectroscopy is the most promising alternative technique for the determination of soil organic carbon (SOC) in laboratories worldwide and that it may serve as a total or partial replacement for the ...
Valderrama, Patrícia, Filgueiras, Paulo Roberto, Fontana, Ademir, Winkler, Thayane Christine Barbosa, Souza, André Marcelo de, Coelho, Maurício Rizzato, Poppi, Ronei Jesus   +6 more
core   +1 more source

Near infrared photoimmunotherapy targeting DLL3 for small cell lung cancer

EBioMedicine, 2020
Background: Small cell lung cancer (SCLC) has a poor prognosis, and its treatment options are limited. Delta-like protein 3 (DLL3) is expressed specifically in SCLC and is considered a promising therapeutic target for patients with this disease ...
Yoshitaka Isobe, Kazuhide Sato, Yuko Nishinaga, Kazuomi Takahashi, Shunichi Taki, Hirotoshi Yasui, Misae Shimizu, Rena Endo, Chiaki Koike, Noriko Kuramoto, Hiroshi Yukawa, Shota Nakamura, Takayuki Fukui, Koji Kawaguchi, Toyofumi F. Chen-Yoshikawa, Yoshinobu Baba, Yoshinori Hasegawa   +16 more
doaj   +1 more source

The application of near infrared spectroscopy in nutritional intervention studies [PDF]

, 2013
Functional near infrared spectroscopy (NIRS) is a non-invasive optical imaging technique used to monitor cerebral blood flow (CBF) and by proxy neuronal activation.
Kennedy, David, Philippa A Jackson, David O. Kennedy, David O Kennedy, Philippa A. Jackson, Jackson, Philippa   +5 more
core   +1 more source

Transient fluid flow improves photoimmunoconjugate delivery and photoimmunotherapy efficacy

iScience, 2023
Summary: Circulating drugs in the peritoneal cavity is an effective strategy for advanced ovarian cancer treatment. Photoimmunotherapy, an emerging modality with potential for the treatment of ovarian cancer, involves near-infrared light activation of ...
Aaron J. Sorrin, Keri Zhou, Katherine May, Cindy Liu, Kathryn McNaughton, Idrisa Rahman, Barry J. Liang, Imran Rizvi, Dana M. Roque, Huang-Chiao Huang   +9 more
doaj   +1 more source

Photoactivated Platinum Complexes: Targeting Membrane Proteins and Organelles for Precision Cancer Therapy

Angewandte Chemie, EarlyView.
This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen, Qiyuan Zhou, Jiaqian Xu, Guangyu Zhu   +3 more
wiley   +2 more sources