Results 61 to 70 of about 2,604,331 (176)

Immediate in vivo target-specific cancer cell death after near infrared photoimmunotherapy

BMC Cancer, 2012
Background Near infrared (NIR) photoimmunotherapy (PIT) is a new type of cancer treatment based on a monoclonal antibody (mAb)-NIR phthalocyanine dye, (IR700) conjugate.
Mitsunaga Makoto, Nakajima Takahito, Sano Kohei, Kramer-Marek Gabriela, Choyke Peter L, Kobayashi Hisataka   +5 more
doaj   +1 more source

Disialoganglioside GD2-Targeted Near-Infrared Photoimmunotherapy (NIR-PIT) in Tumors of Neuroectodermal Origin

Pharmaceutics, 2022
Disialoganglioside (GD2) is a subtype of glycolipids that is highly expressed in tumors of neuroectodermal origins, such as neuroblastoma and osteosarcoma.
Fuyuki F. Inagaki, Takuya Kato, Aki Furusawa, Ryuhei Okada, Hiroaki Wakiyama, Hideyuki Furumoto, Shuhei Okuyama, Peter L. Choyke, Hisataka Kobayashi   +8 more
doaj   +1 more source

Unlocking Long‐Lived Charge‐Separated State in Pentamethine Cyanine Based on Anionic Hofmeister Effect for Photodynamic Immunotherapy

Advanced Science, EarlyView.
Based on the anionic Hofmeister effect, a universal strategy of incorporation of stereo‐π anion BPh4− into a series of Cy5 skeletons to unlock long‐lived charge‐separated states was reported, wherein the weak electronic coupling and low charge recombination driving force hinder the charge recombination process, elevating the oxygen‐independent ROS ...
Xuan Zhao, Lei Jiang, Yingyong Ni, Ting Wang, Junjun Wang, Shengyu Shi, Jianhua Yu, Zhou Lu, Xiaojiao Zhu, Hongping Zhou   +9 more
wiley   +1 more source

Near-infrared photoimmunotherapy: a comparison of light dosing schedules

Oncotarget, 2017
Near infrared photoimmunotherapy (NIR-PIT) is a newly-developed cancer therapy in which a monoclonal antibody is conjugated to a near-infrared photoabsorber, IR700 to form an antibody photoabsorber conjugate (APC). After the APC binds to cancer cells expressing the cognate antigen, exposure to NIR light results in rapid, highly selective necrotic cell ...
Ogata, Fusa, Nagaya, Tadanobu, Nakamura, Yuko, Sato, Kazuhide, Okuyama, Shuhei, Maruoka, Yasuhiro, Choyke, Peter L., Kobayashi, Hisataka   +7 more
openaire   +3 more sources

Wound healing after excision of subcutaneous tumors treated with near‐infrared photoimmunotherapy

Cancer Medicine, 2020
Near‐infrared photoimmunotherapy (NIR‐PIT) is a novel cancer therapy that employs a combination of infrared light and tumor‐targeted monoclonal antibody‐photoabsorber conjugates to cause both direct tumor necrosis and immunogenic cell death.
Adrian Rosenberg, Fuyuki Inagaki, Takuya Kato, Ryuhei Okada, Hiroaki Wakiyama, Aki Furusawa, Peter L. Choyke, Hisataka Kobayashi   +7 more
doaj   +1 more source

HER2 targeting near‐infrared photoimmunotherapy for a CDDP‐resistant small‐cell lung cancer

Cancer Medicine, 2021
Background Human epidermal growth factor receptor 2 (HER2) is tyrosine kinase receptor that belongs to the ErbB family and is overexpressed on the membrane surface of various cancer cells, including small cell lung cancer (SCLC); however, no HER2 ...
Kazuomi Takahashi, Shunichi Taki, Hirotoshi Yasui, Yuko Nishinaga, Yoshitaka Isobe, Toshinori Matsui, Misae Shimizu, Chiaki Koike, Kazuhide Sato   +8 more
doaj   +1 more source

CD47-Targeted Near-Infrared Photoimmunotherapy for Human Bladder Cancer [PDF]

Clinical Cancer Research, 2019
Abstract Purpose: Near-infrared photoimmunotherapy (NIR-PIT) is a localized molecular cancer therapy combining a photosensitizer-conjugated mAb and light energy. CD47 is an innate immune checkpoint widely expressed on bladder cancer cells, but absent from luminal normal urothelium.
Bernhard Kiss, Nynke S. van den Berg, Robert Ertsey, Kelly McKenna, Kathleen E. Mach, Chiyuan Amy Zhang, Jens-Peter Volkmer, Irving L. Weissman, Eben L. Rosenthal, Joseph C. Liao   +9 more
openaire   +2 more sources

Near Infrared Photoimmunotherapy in the Treatment of Disseminated Peritoneal Ovarian Cancer [PDF]

Molecular Cancer Therapeutics, 2015
Abstract Near infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that combines the specificity of intravenously injected antibodies for targeting tumors with the toxicity induced by photosensitizers after exposure to near infrared (NIR) light.
Kazuhide, Sato, Hirofumi, Hanaoka, Rira, Watanabe, Takahito, Nakajima, Peter L, Choyke, Hisataka, Kobayashi   +5 more
openaire   +2 more sources

The role of interventional radiology and molecular imaging for near infrared photoimmunotherapy. [PDF]

Jpn J Radiol
AbstractNear infrared photoimmunotherapy (NIR-PIT) is a recently approved cancer therapy for recurrent head and neck cancer. It involves the intravenous administration of an antibody-photoabsorber (IRDye700DX: IR700) conjugate (APC) to target cancer cells, followed 24 h later by exposure to near infrared light to activate cell-specific cytotoxicity ...
Kobayashi H, Choyke PL.
europepmc   +3 more sources

Photo‐responsive carbon dots for pyroptosis‐mediated anti‐tumor application

Responsive Materials, EarlyView.
Photo‐responsive CDs generate ROS to induce tumor cell pyroptosis, thereby stimulating antitumor immunity. Abstract Pyroptosis refers to a kind of lytic programmed cell death, characterized by the release of pro‐inflammatory cytokines during the process. Owing to its immune response stimulation ability, pyroptosis has garnered considerable attention in
Lingyun Li, Xue Wu, Zekun Yan, Jun Wu, Caishi Huang, Songnan Qu   +5 more
wiley   +1 more source