Results 61 to 70 of about 11,582,729 (334)

Molecular Imaging of Microglial Activation in Amyotrophic Lateral Sclerosis [PDF]

, 2012
There is growing evidence of activated microglia and inflammatory processes in the cerebral cortex in amyotrophic lateral sclerosis (ALS). Activated microglia is characterized by increased expression of the 18 kDa translocator protein (TSPO) in the brain
Arlicot, Nicolas, Baulieu, Jean-Louis, Corcia, Philippe, Cottier, Jean-Philippe, Guilloteau, Denis, Hommet, Caroline, Kassiou, Michael, Nicolas, Guillaume, Praline, Julien, Prunier, Caroline, Ribeiro, Maria-Joao, Roussel, Catherine, Tauber, Clovis, Venel, Yann, Vercouillie, Johnny   +14 more
core   +2 more sources

Analysis of progress and challenges for various patterns of c-MET-targeted molecular imaging: a systematic review

EJNMMI Research, 2017
Background Mesenchymal–epithelial transition factor also named c-MET is a receptor tyrosine kinase for the hepatocyte growth factor that plays a pivotal role in tumorigenesis.
Zhaoguo Han, Yongyi Wu, Kai Wang, Yadi Xiao, Zhen Cheng, Xilin Sun, Baozhong Shen   +6 more
doaj   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Submillimeter Array multiline observations of the massive star-forming region IRAS 18089-1732 [PDF]

, 2004
Submillimeter Array (SMA) observations of the high-mass star-forming region IRAS 18089-1732 in the 1 mm and 850 $\mu$m band with 1 GHz bandwidth reveal a wealth of information.
Beuther, H., Ho, P. T. P., Hunter, T. R., Lim, J., Liu, S. -Y., Ohashi, N., Sollins, P., Sridharan, T. K., Su, Y. N., Zhang, Q., Zhao, J. -H.   +10 more
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent [PDF]

, 2004
We report a new molecular contrast optical coherence tomography (MCOCT) implementation that profiles the contrast agent distribution in a sample by measuring the agent's spectral differential absorption.
Applegate, Brian E., Choma, Michael A., Izatt, Joseph A., McGuckin, Laura E. L., Simon, John D., Yang, Changhuei   +5 more
core   +1 more source

High Performance Molecular Imaging with MALDI Trapped Ion Mobility Time-of-Flight (timsTOF) Mass Spectrometry.

Analytical Chemistry, 2019
Imaging mass spectrometry (IMS) enables the spatially targeted molecular assessment of biological tissues at cellular resolutions. New developments and technologies are essential for uncovering the molecular drivers of native physiological function and ...
J. Spraggins, Katerina V. Djambazova, Emilio S. Rivera, L. Migas, Elizabeth K. Neumann, A. Fuetterer, J. Suetering, Niels Goedecke, A. Ly, R. Van de Plas, R. Caprioli   +10 more
semanticscholar   +1 more source

Synthesis of an Al18F radiofluorinated GLU-UREA-LYS(AHX)-HBED-CC PSMA ligand in an automated synthesis platform

EJNMMI Radiopharmacy and Chemistry, 2018
Background Overexpression of prostatic membrane antigen (PSMA) is associated with the progression and prognosis of prostate cancer. There are numerous studies using this peptide with the 68Ga radionuclide.
Javier Giglio, Maia Zeni, Eduardo Savio, Henry Engler   +3 more
doaj   +1 more source

Extending the clinical capabilities of short- and long-lived positron-emitting radionuclides through high sensitivity PET/CT

Cancer Imaging, 2022
This review describes the main benefits of using long axial field of view (LAFOV) PET in clinical applications. As LAFOV PET is the latest development in PET instrumentation, many studies are ongoing that explore the potentials of these systems, which ...
Joyce van Sluis, Ronald Borra, Charalampos Tsoumpas, Johannes H. van Snick, Mostafa Roya, Dik ten Hove, Adrienne H. Brouwers, Adriaan A. Lammertsma, Walter Noordzij, Rudi A.J.O. Dierckx, Riemer H.J.A. Slart, Andor W.J.M. Glaudemans   +11 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source