Results 1 to 10 of about 353,887 (261)

Evaluation of molecular inversion probe versus TruSeq® custom methods for targeted next-generation sequencing. [PDF]

open access: goldPLoS ONE, 2020
Resolving the genetic architecture of painful neuropathy will lead to better disease management strategies. We aimed to develop a reliable method to re-sequence multiple genes in a large cohort of painful neuropathy patients at low cost.
Rowida Almomani   +20 more
doaj   +5 more sources

Molecular inversion probe: a new tool for highly specific detection of plant pathogens. [PDF]

open access: goldPLoS ONE, 2014
Highly specific detection methods, capable of reliably identifying plant pathogens are crucial in plant disease management strategies to reduce losses in agriculture by preventing the spread of diseases. We describe a novel molecular inversion probe (MIP)
Han Yih Lau   +3 more
doaj   +5 more sources

Development, validation and application of single molecule molecular inversion probe based novel integrated genetic screening method for 29 common lysosomal storage disorders in India [PDF]

open access: goldHuman Genomics
Background Current clinical diagnosis pathway for lysosomal storage disorders (LSDs) involves sequential biochemical enzymatic tests followed by DNA sequencing, which is iterative, has low diagnostic yield and is costly due to overlapping clinical ...
Harsh Sheth   +41 more
doaj   +5 more sources

A molecular inversion probe assay for detecting alternative splicing [PDF]

open access: goldBMC Genomics, 2010
Absract Background A sensitive, high-throughput method for monitoring pre-mRNA splicing on a genomic scale is needed to understand the spectrum of alternatively spliced mRNA in human cells.
Palm Curtis   +4 more
doaj   +5 more sources

High-throughput genotyping of Plasmodium vivax in the Peruvian Amazon via molecular inversion probes [PDF]

open access: greenNature Communications
Plasmodium vivax transmission occurs throughout the tropics and is an emerging threat in areas of Plasmodium falciparum decline, causing relapse infections that complicate treatment and control. Targeted sequencing for P.
Zachary R. Popkin-Hall   +12 more
doaj   +9 more sources

Investigating Single-Molecule Molecular Inversion Probes for Medium-Scale Targeted DNA Methylation Analysis [PDF]

open access: diamondEpigenomes
Background: Epigenetic biomarkers, particularly CpG methylation, are increasingly employed in clinical and forensic settings. However, we still lack a cost-effective, sensitive, medium-scale method for the analysis of hundreds to thousands of user ...
Roy B. Simons   +3 more
doaj   +4 more sources

Correction: Evaluation of molecular inversion probe versus TruSeq® custom methods for targeted next-generation sequencing. [PDF]

open access: yesPLoS ONE, 2021
[This corrects the article DOI: 10.1371/journal.pone.0238467.].
Rowida Almomani   +20 more
doaj   +3 more sources

Detection of 16S rRNA and KPC Genes from Complex Matrix Utilizing a Molecular Inversion Probe Assay for Next-Generation Sequencing [PDF]

open access: yesScientific Reports, 2018
Targeted sequencing promises to bring next-generation sequencing (NGS) into routine clinical use for infectious disease diagnostics. In this context, upfront processing techniques, including pathogen signature enrichment, must amplify multiple targets of
Christopher P. Stefan   +2 more
doaj   +3 more sources

A molecular inversion probe-based next-generation sequencing panel to detect germline mutations in Chinese early-onset colorectal cancer patients. [PDF]

open access: goldOncotarget, 2017
The currently known Mendelian colorectal cancer (CRC) predisposition syndromes account for ∼5–10% of all CRC cases, and are caused by inherited germline mutations in single CRC predisposing genes.
Zhang J   +17 more
europepmc   +4 more sources

Genome-wide copy number aberrations and HER2 and FGFR1 alterations in primary breast cancer by molecular inversion probe microarray. [PDF]

open access: goldOncotarget, 2017
Breast cancer remains the second leading cause of cancer-related death in women despite stratification based on standard hormonal receptor (HR) and HER2 testing. Additional prognostic markers are needed to improve breast cancer treatment. Chromothripsis,
Chen H   +20 more
europepmc   +4 more sources

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