Results 1 to 10 of about 206,828 (101)

Molecular inversion probe-based SPR biosensing for specific, label-free and real-time detection of regional DNA methylation [PDF]

Chemical Communications, 2014
DNA methylation has the potential to be a clinically important biomarker in cancer. This communication reports a real-time and label-free biosensing strategy for DNA methylation detection in the cancer cell line.
Laura G. Carrascosa, Abu Ali Ibn Sina, Ramkumar Palanisamy, Borja Sepúlveda, Marinus A. Otte, Sakandar Rauf, Muhammad J. A. Shiddiky, Matt Trau   +7 more
core   +8 more sources

High-Throughput Genotyping of Plasmodium vivax in the Peruvian Amazon via Molecular Inversion Probes

medRxiv
Plasmodium vivax transmission occurs throughout the tropics and is an emerging threat in areas of Plasmodium falciparum decline, causing relapse infections that complicate treatment and control. Targeted sequencing for P.
Zachary R. Popkin-Hall, Karamoko Niaré, Rebecca Crudale, Alfred Simkin, Abebe A. Fola, Juan F. Sánchez, Danielle L. Pannebaker, David Giesbrecht, Isaac E. Kim, Özkan Aydemir, Jeffrey A. Bailey, Hugo O. Valdivia, Jonathan J. Juliano   +12 more
semanticscholar   +7 more sources

Highly multiplexed molecular inversion probe genotyping: Over 10,000 targeted SNPs genotyped in a single tube assay [PDF]

Genome Research, 2005
Large-scale genetic studies are highly dependent on efficient and scalable multiplex SNP assays. In this study, we report the development of Molecular Inversion Probe technology with four-color, single array detection, applied to large-scale genotyping ...
Paul Hardenbol, Fuli Yu, John W. Belmont, Jennifer MacKenzie, Carsten Bruckner, Tiffany Brundage, Andrew Boudreau, Steve Chow, Jim Eberle, Ayça Erbilgin, Mat Falkowski, R.C. Fitzgerald, Sy Ghose, Oleg Iartchouk, Maneesh Jain, George Karlin‐Neumann, Xiuhua Lu, Xin Miao, Bridget Moore, Martin Moorhead, Eugeni Namsaraev, Shiran Pasternak, Eunice Prakash, Karen Tran, Zhiyong Wang, Hywel B. Jones, Ronald W. Davis, T. D. Willis, Richard A. Gibbs   +28 more
openalex   +2 more sources

Development, validation and application of single molecule molecular inversion probe based novel integrated genetic screening method for 29 common lysosomal storage disorders in India [PDF]

Human Genomics
Background Current clinical diagnosis pathway for lysosomal storage disorders (LSDs) involves sequential biochemical enzymatic tests followed by DNA sequencing, which is iterative, has low diagnostic yield and is costly due to overlapping clinical ...
Harsh Sheth, Aadhira Nair, Riddhi Bhavsar, Mahesh Kamate, Vykuntaraju K. Gowda, Ashish Bavdekar, Sandeep Kadam, Sheela Nampoothiri, Inusha Panigrahi, Anupriya Kaur, Siddharth Shah, Sanjeev Mehta, Sujatha Jagadeesan, Indrani Suresh, Seema Kapoor, Shruti Bajaj, Radha Rama Devi, Ashka Prajapati, Koumudi Godbole, Harsh Patel, Zulfiqar Luhar, Raju Shah, Anand Iyer, Sunita Bijarnia, Ratna Dua Puri, Mamta Muranjan, Ami A. Shah, Suvarna Magar, Neerja Gupta, Naresh Tayade, Ajit Gandhi, Ajit Sowani, Shrutikaa Kale, Anil Jalan, Dhaval Solanki, Ashwin Dalal, Shrikant Mane, C. Ratna Prabha, Frenny Sheth, Chaitanya G. Joshi, Madhvi Joshi, Jayesh Sheth   +41 more
openalex   +2 more sources

Evaluation of molecular inversion probe versus TruSeq® custom methods for targeted next-generation sequencing

PLoS ONE, 2020
Resolving the genetic architecture of painful neuropathy will lead to better disease management strategies. We aimed to develop a reliable method to re-sequence multiple genes in a large cohort of painful neuropathy patients at low cost.
Rowida Almomani, Margherita Marchi, Maurice Sopacua, Patrick Lindsey, Erika Salvi, Bart de Koning, Silvia Santoro, Stefania Magri, H.J.M. Smeets, Filippo Martinelli Boneschi, Rayaz R. Malik, Dan Ziegler, Janneke G. J. Hoeijmakers, Gidon J. Bönhof, Sulayman D. Dib‐Hajj, Stephen G. Waxman, Ingemar S.J. Merkies, Giuseppe Lauria, Catharina G. Faber, Monique M. Gerrits   +19 more
openalex   +3 more sources

Analysis of molecular inversion probe performance for allele copy number determination [PDF]

Genome Biology, 2007
We have developed a new protocol for using molecular inversion probes to accurately and specifically measure allele copy number. The new protocol provides for significant improvements, including the reduction of input DNA (from 2 μg) by more than 25-fold
Yuker Wang, Martin Moorhead, George Karlin‐Neumann, Nicholas J. Wang, James Ireland, Steven Lin, Chunnuan Chen, Laura M. Heiser, Koei Chin, Laura J. Esserman, Joe W. Gray, Paul T. Spellman, Malek Faham   +12 more
openalex   +2 more sources

A molecular inversion probe assay for detecting alternative splicing [PDF]

BMC Genomics, 2010
AbsractBackgroundA sensitive, high-throughput method for monitoring pre-mRNA splicing on a genomic scale is needed to understand the spectrum of alternatively spliced mRNA in human cells.ResultsWe adapted Molecular Inversion Probes (MIPs), a padlock ...
Shengrong Lin, Wenyi Wang, Curtis Palm, Ronald W. Davis, Kara Juneau   +4 more
openalex   +2 more sources

A molecular inversion probe-based next-generation sequencing panel to detect germline mutations in Chinese early-onset colorectal cancer patients

OncoTarget, 2017
The currently known Mendelian colorectal cancer (CRC) predisposition syndromes account for ∼5–10% of all CRC cases, and are caused by inherited germline mutations in single CRC predisposing genes.
Junxiao Zhang, Xiaoyan Wang, Richarda M. de Voer, Jayne Y. Hehir‐Kwa, Eveline J. Kamping, Robbert D.A. Weren, Marcel Nelen, Alexander Hoischen, Marjolijn J. L. Ligtenberg, Nicoline Hoogerbrugge, Xiangling Yang, Zihuan Yang, Xinjuan Fan, Lei Wang, Huanliang Liu, Jianping Wang, Roland P. Kuiper, Ad Geurts van Kessel   +17 more
openalex   +3 more sources

A molecular inversion probe and sequencing-based microsatellite instability assay for high throughput cancer diagnostics and Lynch syndrome screening [PDF]

bioRxiv, 2018
Background Clinical guidelines recommend microsatellite instability (MSI) and BRAF V600E testing of all colorectal cancers (CRCs) to screen for Lynch syndrome (LS), a hereditary predisposition to cancer.
Richard Gallon, Christine Hayes, Lisa Redford, Ghanim Alhilal, Ottie O’Brien, Amanda Waltham, Stephanie Needham, Mark J. Arends, Anca Oniscu, Ángel Alonso, Sira Moreno Laguna, Harsh Sheth, Mauro Santibanez‐Koref, Michael S. Jackson, John Burn   +14 more
openalex   +2 more sources

Molecular Inversion Probe: A New Tool for Highly Specific Detection of Plant Pathogens

PLoS ONE, 2014
Highly specific detection methods, capable of reliably identifying plant pathogens are crucial in plant disease management strategies to reduce losses in agriculture by preventing the spread of diseases. We describe a novel molecular inversion probe (MIP)
Han Yih Lau, Ramkumar Palanisamy, Matt Trau, José Ramón Botella   +3 more
openalex   +3 more sources