Results 1 to 10 of about 465,075 (315)

Exploring the Associations and Molecular Impacts of miR-146a/rs2910164 and miR-196a2/rs185070757 with Rheumatoid Arthritis in a Pakistani Population

Lifestyle Genomics, 2023
Introduction: MicroRNAs (miRNAs) are a new class of molecules that participate in post-transcriptional regulation of gene expression and hence have been reported to have a crucial role in the pathogenesis of rheumatoid arthritis (RA).
Yasir Ali, Aamir Khan, Mehran Akhtar, Suleman Khan, Zia Ul Islam, Nadia Farooqi, Aftab Ali Shah, Yangchao Chen, Fazal Jalil   +8 more
doaj   +1 more source

Comprehensive evaluation of structural variation detection algorithms for whole genome sequencing

Genome Biology, 2019
Background Structural variations (SVs) or copy number variations (CNVs) greatly impact the functions of the genes encoded in the genome and are responsible for diverse human diseases.
Shunichi Kosugi, Yukihide Momozawa, Xiaoxi Liu, Chikashi Terao, Michiaki Kubo, Yoichiro Kamatani   +5 more
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The Polymorphism of Pituitary Factor 1 (POU1F1) in Cattle

Scientific Papers Animal Science and Biotechnologies, 2023
The development and function of mammary gland is mainly controlled by growth hormone and prolactin, two protein hormones secreted by the anterior pituitary gland.
Teodora Crina Carsai, Valentin Adrian Balteanu, Augustin Vlaic, Viorica Cosier   +3 more
doaj  

Generation of an iPSC line from a retinitis pigmentosa patient carrying a homozygous mutation in CERKL and a healthy sibling

Stem Cell Research, 2019
Dermal fibroblasts from an autosomal recessive retinitis pigmentosa (RP) patient, homozygous for the mutation c.769 C>T, p.Arg257Ter, in CERKL (Ceramide Kinase-Like) gene, and a healthy sibling were derived and reprogrammed by Sendai virus. The generated
Arantxa Bolinches-Amorós, Marian León, Verónica del Buey Furió, Gemma Marfany, Roser Gonzàlez-Duarte, Slaven Erceg, Dunja Lukovic   +6 more
doaj   +1 more source

Poor association between dihydropyrimidine dehydrogenase (DPYD) genotype and fluoropyrimidine‐induced toxicity in an Asian population

Cancer Medicine, 2023
Objective Dihydropyrimidine dehydrogenase (DPYD) genotype is closely associated with fluoropyrimidine (FP)‐induced toxicities in Caucasian population and European Medicines Agency now recommends DPYD genotype‐based FP dosing strategy.
Masashi Kanai, Takahisa Kawaguchi, Masahito Kotaka, Dai Manaka, Junichi Hasegawa, Akinori Takagane, Yoshinori Munemoto, Takeshi Kato, Tetsuya Eto, Tetsuo Touyama, Takanori Matsui, Katsunori Shinozaki, Shigemi Matsumoto, Tsunekazu Mizushima, Masaki Mori, Junichi Sakamoto, Atsushi Ohtsu, Takayuki Yoshino, Shigetoyo Saji, Fumihiko Matsuda   +19 more
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Real-World Data on Liquid Biopsy Use in Non-Small Cell Lung Cancer in the Community Setting [PDF]

Journal of Immunotherapy and Precision Oncology, 2021
Introduction: The yield of adding plasma-based next-generation sequencing (NGS) to tissue NGS for the detection of actionable aberrations (AAs) has been reported; however, additional studies are needed to determine utility in the clinical setting.
Kathrin Dvir, Gliceida M. Galarza-Fortuna, Joel M. Haines, Paulina Gines, Ana L. Ruiz, Estelamari Rodriguez   +5 more
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VISMapper: ultra-fast exhaustive cartography of viral insertion sites for gene therapy

BMC Bioinformatics, 2017
Background The possibility of integrating viral vectors to become a persistent part of the host genome makes them a crucial element of clinical gene therapy.
José M. Juanes, Asunción Gallego, Joaquín Tárraga, Felipe J. Chaves, Pablo Marín-Garcia, Ignacio Medina, Vicente Arnau, Joaquín Dopazo   +7 more
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Genotyping and zoonotic potential of Enterocytozoon bieneusi in cattle farmed in Hainan Province, the southernmost region of China

Parasite, 2020
Enterocytozoon bieneusi is an intestinal pathogen that infects a wide range of species, including humans. Cattle constitute an important host for E. bieneusi; however, there is a scarcity of information on the prevalence and genotyping of E.
Zheng Xin-Li, Zhou Huan-Huan, Ren Gangxu, Ma Tian-Ming, Cao Zong-Xi, Wei Li-Min, Liu Quan-Wei, Wang Feng, Zhang Yan, Liu Hai-Long, Xing Man-Ping, Huang Li-Li, Chao Zhe, Lu Gang   +13 more
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Multilocus Sequence Typing Reveals Extensive Genetic Diversity of the Emerging Fungal Pathogen Scedosporium aurantiacum

Frontiers in Cellular and Infection Microbiology, 2021
Scedosporium spp. are the second most prevalent filamentous fungi after Aspergillus spp. recovered from cystic fibrosis (CF) patients in various regions of the world.
Azian Harun, Azian Harun, Alex Kan, Katharina Schwabenbauer, Felix Gilgado, Haybrig Perdomo, Carolina Firacative, Heidemarie Losert, Sarimah Abdullah, Sandrine Giraud, Josef Kaltseis, Mark Fraser, Walter Buzina, Michaela Lackner, Christopher C. Blyth, Christopher C. Blyth, Ian Arthur, Johannes Rainer, José F. Cano Lira, Josep Guarro Artigas, Kathrin Tintelnot, Monica A. Slavin, Christopher H. Heath, Jean-Philippe Bouchara, Sharon C. A. Chen, Sharon C. A. Chen, Wieland Meyer   +26 more
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Genotyping

Egyptian Journal of Aquatic Research, 2014
Culture-independent 16S rRNA gene analysis approach was used to explore and evaluate archaea in a polluted site, El-Zeitia, Suez Gulf, Egypt. Metagenomic DNA was extracted from a sediment sample.
Hosam Easa Elsaied
doaj   +1 more source