Results 91 to 100 of about 353,887 (261)
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
12mm line survey of the dense molecular gas towards the W28 field TeV gamma-ray sources [PDF]
, 2010 We present 12mm Mopra observations of dense molecular gas towards the W28 supernova remnant (SNR) field. The focus is on the dense molecular gas towards the TeV gamma-ray sources detected by the H.E.S.S. telescopes, which likely trace the cosmic-rays from W28 and possibly other sources in the region.
arxiv +1 more source
Inverse Measurements in Active Nematics [PDF]
arXiv, 2023 We present a framework to take new measurements in nematic systems that contain active elements such as molecular motors. Spatio-temporal fields of stress, traction, velocity, pressure, and forces are estimated jointly from microscopy images alone. Our inverse-problem approach ensures that these fields comply with physical laws and are accurate at ...
arxiv
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Amplification without inversion, fast light and optical bistability in a duplicated two-level system [PDF]
, 2013 The optical properties of a weak probe field in a duplicated two-level system are investigated in multiphoton resonance (MPR) condition and beyond it. It is shown that, by changing the relative phase of applied fields, the absorption switches to the amplification without inversion in MPR condition.
arxiv +1 more source
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source
Visualization of atomic structure using AFM: theoretical description [PDF]
Phys. Low-Dim. Struct. (2002), 5/6, pp.7-12, 2011 We suggest simple model of image formation in atomic force microscope (AFM) taking into account contact deformations of probe and sample during scanning. The model explains the possibility of AFM visualization of regular atomic or molecular structure when probe-sample contact area is greater than an area per atom or molecule in surface lattice.
arxiv
The Metallicity Dependence of the HI Shielding Layers in Nearby Galaxies [PDF]
, 2018 We investigate the metallicity dependence of HI surface densities in star-forming regions along many lines of sight within 70 nearby galaxies, probing kpc to 50 pc scales. We employ HI, SFR, stellar mass, and metallicity (gradient) measurements from the literature, spanning a wide range (5 dex) in stellar and gas mass and (1.6 dex) in metallicity.
arxiv +1 more source
FEBS Open Bio, EarlyView.We provide a step‐by‐step guide for producing E140 antigen fragments from Plasmodium berghei (Pb1) and Plasmodium vivax (Pv1). Pb1/Pv1 are expressed in E. coli, solubilized by freeze–thawing, refolded by slow dilution, purified by affinity chromatography (IMAC), then concentrated and subjected to quality control.
Rodolfo Ferreira Marques +5 more
wiley +1 more source
Identification of inhibitors of the Salmonella FraB deglycase, a drug target
FEBS Open Bio, EarlyView.A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law +6 more
wiley +1 more source