Results 11 to 20 of about 155,803 (258)

An improved molecular inversion probe based targeted sequencing approach for low variant allele frequency. [PDF]

NAR Genom Bioinform, 2022
Deep targeted sequencing technologies are still not widely used in clinical practice due to the complexity of the methods and their cost. The Molecular Inversion Probes (MIP) technology is cost effective and scalable in the number of targets, however ...
Biezuner T, Brilon Y, Arye AB, Oron B, Kadam A, Danin A, Furer N, Minden MD, Hwan Kim DD, Shapira S, Arber N, Dick J, Thavendiranathan P, Moskovitz Y, Kaushansky N, Chapal-Ilani N, Shlush LI.   +16 more
europepmc   +5 more sources

Molecular inversion probe assay for allelic quantitation. [PDF]

Methods Mol Biol, 2009
Molecular inversion probe (MIP) technology has been demonstrated to be a robust platform for large-scale dual genotyping and copy number analysis. Applications in human genomic and genetic studies include the possibility of running dual germline genotyping and combined copy number variation ascertainment.
Ji H, Welch K.
europepmc   +7 more sources

Molecular inversion probe analysis detects novel copy number alterations in Ewing sarcoma. [PDF]

Cancer Genet, 2012
Ewing sarcoma (ES) is the second most common bone tumor in children and young adults, with dismal outcomes for metastatic and relapsed disease. To better understand the molecular pathogenesis of ES and to identify new prognostic markers, we used molecular inversion probes (MIPs) to evaluate copy number alterations (CNAs) and loss of heterozygosity (LOH)
Jahromi MS, Putnam AR, Druzgal C, Wright J, Spraker-Perlman H, Kinsey M, Zhou H, Boucher KM, Randall RL, Jones KB, Lucas D, Rosenberg A, Thomas D, Lessnick SL, Schiffman JD.   +14 more
europepmc   +7 more sources

Performance of molecular inversion probe DR23K and Paragon MAD4HatTeR Amplicon sequencing panels for detection of Plasmodium falciparum mutations associated with antimalarial drug resistance [PDF]

Malaria Journal
Background Molecular surveillance of drug-resistant Plasmodium falciparum is crucial for malaria control in endemic regions. Two targeted-resequencing tools, the Molecular Inversion Probe (MIP) drug resistance panel DR23K and the Multiplexed Amplicons ...
Thomas Katairo, Victor Asua, Bienvenu Nsengimaana, Stephen Tukwasibwe, Francis D. Semakuba, Innocent Wiringilimaana, Brian A. Kagurusi, Caroline Mwubaha, Jackie Nakasaanya, Shreeya Garg, Shahiid Kiyaga, Monica Mbabazi, Kisakye D. Kabbale, Alisen Ayitewala, Samuel L. Nsobya, Moses R. Kamya, Isaac Ssewanyana, Jeffrey A. Bailey, Andrés Aranda-Díaz, Philip J. Rosenthal, Bryan Greenhouse, Jessica Briggs, Melissa D. Conrad   +22 more
doaj   +3 more sources

Quantification and localization of oncogenic receptor tyrosine kinase variant transcripts using molecular inversion probes [PDF]

Scientific Reports, 2018
Oncogenic membrane receptor tyrosine kinases such as MET and EGFR, or auto-active variants thereof, are important targets for cancer precision therapy.
Corina N. A. M. van den Heuvel, Arvid I. Das, Tessa de Bitter, Femke Simmer, Thomas Wurdinger, Miguel Angel Molina-Vila, William P. J. Leenders   +6 more
doaj   +7 more sources

Genome-wide copy number aberrations and HER2 and FGFR1 alterations in primary breast cancer by molecular inversion probe microarray. [PDF]

Oncotarget, 2017
Breast cancer remains the second leading cause of cancer-related death in women despite stratification based on standard hormonal receptor (HR) and HER2 testing. Additional prognostic markers are needed to improve breast cancer treatment. Chromothripsis,
Chen H, Singh RR, Lu X, Huo L, Yao H, Aldape K, Abraham R, Virani S, Mehrotra M, Mishra BM, Bousamra A, Albarracin C, Wu Y, Roy-Chowdhuri S, Kanagal-Shamanna R, Routbort MJ, Medeiros LJ, Patel KP, Broaddus R, Sahin A, Luthra R.   +20 more
europepmc   +4 more sources

PathogenMIPer: a tool for the design of molecular inversion probes to detect multiple pathogens [PDF]

BMC Bioinformatics, 2006
Background Here we describe PathogenMIPer, a software program for designing molecular inversion probe (MIP) oligonucleotides for use in pathogen identification and detection.
Akhras Michael, Karhanek Miloslav, Thiyagarajan Sreedevi, Davis Ronald W, Pourmand Nader   +4 more
doaj   +6 more sources

Analysis of molecular inversion probe performance for allele copy number determination [PDF]

Genome Biology, 2007
We have developed a new protocol for using molecular inversion probes to accurately and specifically measure allele copy number. The new protocol provides for significant improvements, including the reduction of input DNA (from 2 μg) by more than 25-fold
Yuker Wang, Martin Moorhead, George Karlin‐Neumann, Nicholas J. Wang, James Ireland, Steven Lin, Chunnuan Chen, Laura M. Heiser, Koei Chin, Laura J. Esserman, Joe W. Gray, Paul T. Spellman, Malek Faham   +12 more
semanticscholar   +10 more sources

High quality copy number and genotype data from FFPE samples using Molecular Inversion Probe (MIP) microarrays [PDF]

BMC Medical Genomics, 2009
Background A major challenge facing DNA copy number (CN) studies of tumors is that most banked samples with extensive clinical follow-up information are Formalin-Fixed Paraffin Embedded (FFPE).
Bondy Melissa, Walther Axel, Warren Robert, Richardson Andrea L, Wang Zhigang C, Moorhead Martin, Zhang Li, Sapolsky Ronald, Karlin-Neumann George, Carlton Victoria EH, Wang Yuker, Sahin Aysegul, Krahe Ralf, Tuna Musaffe, Thompson Patricia A, Spellman Paul T, Gray Joe W, Mills Gordon B, Faham Malek   +18 more
doaj   +3 more sources

Molecular Inversion Probe-Based Sequencing of USH2A Exons and Splice Sites as a Cost-Effective Screening Tool in USH2 and arRP Cases. [PDF]

Int J Mol Sci, 2021
A substantial proportion of subjects with autosomal recessive retinitis pigmentosa (arRP) or Usher syndrome type II (USH2) lacks a genetic diagnosis due to incomplete USH2A screening in the early days of genetic testing.
Reurink J, Dockery A, Oziębło D, Farrar GJ, Ołdak M, Ten Brink JB, Bergen AA, Rinne T, Yntema HG, Pennings RJE, van den Born LI, Aben M, Oostrik J, Venselaar H, Plomp AS, Khan MI, van Wijk E, Cremers FPM, Roosing S, Kremer H.   +19 more
europepmc   +2 more sources