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Discordant ALK Status in Non-Small Cell Lung Carcinoma: A Detailed Reevaluation Comparing IHC, FISH, and NGS Analyses. [PDF]
Int J Mol SciTobiášová K +7 more
europepmc +1 more source
Molecular inversion probe assay. [PDF]
Methods in molecular biology, 2007 We have described molecular inversion probe technologies for large-scale genetic analyses. This technique provides a comprehensive and powerful tool for the analysis of genetic variation and enables affordable, large-scale studies that will help uncover the genetic basis of complex disease and explain the individual variation in response to ...
Farnaz Absalan, M. Ronaghi
semanticscholar +3 more sources
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Neurological Sciences, 2019
Parkinson's disease (PD) is a common neurodegenerative disorder with multiple factors contributing to disease pathogenesis. Previous studies implicated the involvement of the transcription factor hypoxia inducible factor 1 alpha (HIF1A) in PD through its transcriptional regulation of PD-associated genes. This study uses molecular inversion probes (MIPs)
Lixia Qin +8 more
semanticscholar +3 more sources
Parkinson's disease (PD) is a common neurodegenerative disorder with multiple factors contributing to disease pathogenesis. Previous studies implicated the involvement of the transcription factor hypoxia inducible factor 1 alpha (HIF1A) in PD through its transcriptional regulation of PD-associated genes. This study uses molecular inversion probes (MIPs)
Lixia Qin +8 more
semanticscholar +3 more sources
Multiplexed genotyping with sequence-tagged molecular inversion probes [PDF]
Nature Biotechnology, 2003 We report on the development of molecular inversion probe (MIP) genotyping, an efficient technology for large-scale single nucleotide polymorphism (SNP) analysis. This technique uses MIPs to produce inverted sequences, which undergo a unimolecular rearrangement and are then amplified by PCR using common primers and analyzed using universal sequence tag
Ronald W. Davis +10 more
openaire +2 more sources
Epiallele Quantification Using Molecular Inversion Probes
Analytical Chemistry, 2011The location and level of DNA methylation within a genome is emerging as an important biomarker for cancer diagnosis. Despite its potential, it is difficult to comprehensively analyze the epialleles that are often found in a biological sample. Therefore, an assay utilizing molecular inversion probes was designed and used to expose and quantify ...
Palanisamy, Ramkumar +2 more
openaire +4 more sources
A Molecular Rotor That Probes the Helical Inversion of Stiff-Stilbene
Organic Letters, 2020Probing the inversion kinetics of a molecular helix is inherently a challenging task. We demonstrate herein that a fast-rotating pentiptycene component could function as an external NMR probe to afford the kinetic information on the inversion of a neighboring helical stiff-stilbene unit.
Zi-Jian Chen +6 more
openaire +3 more sources
Molecular inversion probes for sensitive detection of Mycobacterium tuberculosis
Journal of Microbiological Methods, 2008Nucleic acid-based detection of Mycobacterium tuberculosis infections has the potential to improve the analysis of the tuberculosis epidemiology and patient care by increasing the specificity and sensitivity of diagnosis. One potential diagnostic sequence, the DR locus, is present in all isolates of M. tuberculosis complex bacteria. It encodes no known
Sibelle Borsuk +3 more
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Sensitive Quantification of Somatic Mutations Using Molecular Inversion Probes
Analytical Chemistry, 2011Somatic mutations in DNA can serve as cancer specific biomarkers and are increasingly being used to direct treatment. However, they can be difficult to detect in tissue biopsies because there is often only a minimal amount of sample and the mutations are often masked by the presence of wild type alleles from nontumor material in the sample.
Hirani, Rena +4 more
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