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Epiallele Quantification Using Molecular Inversion Probes
Analytical Chemistry, 2011The location and level of DNA methylation within a genome is emerging as an important biomarker for cancer diagnosis. Despite its potential, it is difficult to comprehensively analyze the epialleles that are often found in a biological sample. Therefore, an assay utilizing molecular inversion probes was designed and used to expose and quantify ...
Palanisamy, Ramkumar +2 more
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A Molecular Rotor That Probes the Helical Inversion of Stiff-Stilbene
Organic Letters, 2020Probing the inversion kinetics of a molecular helix is inherently a challenging task. We demonstrate herein that a fast-rotating pentiptycene component could function as an external NMR probe to afford the kinetic information on the inversion of a neighboring helical stiff-stilbene unit.
Zi-Jian Chen +6 more
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Molecular inversion probes for sensitive detection of Mycobacterium tuberculosis
Journal of Microbiological Methods, 2008Nucleic acid-based detection of Mycobacterium tuberculosis infections has the potential to improve the analysis of the tuberculosis epidemiology and patient care by increasing the specificity and sensitivity of diagnosis. One potential diagnostic sequence, the DR locus, is present in all isolates of M. tuberculosis complex bacteria. It encodes no known
Sibelle Borsuk +3 more
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Sensitive Quantification of Somatic Mutations Using Molecular Inversion Probes
Analytical Chemistry, 2011Somatic mutations in DNA can serve as cancer specific biomarkers and are increasingly being used to direct treatment. However, they can be difficult to detect in tissue biopsies because there is often only a minimal amount of sample and the mutations are often masked by the presence of wild type alleles from nontumor material in the sample.
Hirani, Rena +4 more
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Dynamic molecular interferometer: Probe of inversion symmetry in I2− photodissociation
The Journal of Chemical Physics, 2005Time-resolved photoelectron imaging of negative ions is employed to examine 780-nm dissociation dynamics of I2−, emphasizing the effects of interference in time-resolved photoelectron angular distributions obtained with 390-nm probe. No energetic changes are observed after about 700fs, but the evolution of the photoelectron anisotropy persists for up ...
Andrei Sanov +2 more
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Utilization of Molecular Inversion Probes in Malaria Sequencing
2014While massively parallel sequencing of whole genomes shed light on many previously puzzling genetic questions, the high costs associated with this approach makes its use impractical when large cohorts need to be sequenced at high coverage. Available capture technologies reduces the sequencing costs by enriching template material for the regions of ...
Jeffrey A. Bailey +4 more
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A New Topological Index for Molecular Probes Used in Inverse Gas Chromatography
Journal of Colloid and Interface Science, 1997The application of the new morphological index chiT, which is an extension of Wiener's index for the evaluation of the retention data of apolar and polar solutes used in inverse gas chromatography, is described. Indeed, chiT performs satisfactorily, surpassing the other molecular descriptors employed so far.
Eric Brendle, Eugène Papirer
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Molecular inversion probes: a novel microarray technology and its application in cancer research
Cancer Genetics, 2012The molecular inversion probe (MIP) assay technology was originally developed for single nucleotide polymorphism (SNP) genotyping, but has subsequently been used for identifying other types of genetic variation including focal insertions and deletions, larger copy number alterations (CNAs), loss of heterozygosity (LOH), and most recently, for somatic ...
MariEllen Cottman +2 more
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Adapting molecular inversion probe (MIP) technology for allele quantification in childhood leukemia
Journal of Clinical Oncology, 20079530 Background: Leukemia accounts for ∼40% of newly diagnosed pediatric malignancies, and relapsed leukemia is the leading cause of death in childhood cancer. Genomic instability events contribute to neoplastic development and have been used to classify and risk stratify non-leukemic adult and pediatric tumors.
Gary V. Dahl +7 more
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Molecular Inversion Probes (MIPs) Identify Novel Areas of Allelic Imbalance in Childhood Leukemia.
Blood, 2007Abstract Background: Leukemia accounts for over 30% of newly diagnosed childhood malignancies, and is the leading cause of death for children with cancer. Genomic instability events contribute to tumorigenesis and have been used to classify and risk stratify adult and pediatric cancers.
Ronald W. Davis +8 more
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