Results 21 to 30 of about 155,803 (258)

Molecular Inversion Probe Analysis of Gene Copy Alterations Reveals Distinct Categories of Colorectal Carcinoma [PDF]

Cancer Research, 2006
Genomic instability is a major feature of neoplastic development in colorectal carcinoma and other cancers. Specific genomic instability events, such as deletions in chromosomes and other alterations in gene copy number, have potential utility as ...
Hanlee P. Ji, Jochen Kumm, Michael Zhang, Kyle Farnam, Keyan Salari, Malek Faham, James M. Ford, Ronald W. Davis   +7 more
semanticscholar   +6 more sources

Accurate Pan-Cancer Molecular Diagnosis of Microsatellite Instability by Single-Molecule Molecular Inversion Probe Capture and High-Throughput Sequencing. [PDF]

Clin Chem, 2018
BACKGROUND Microsatellite instability (MSI) is an emerging actionable phenotype in oncology that informs tumor response to immune checkpoint pathway immunotherapy.
Waalkes A, Smith N, Penewit K, Hempelmann J, Konnick EQ, Hause RJ, Pritchard CC, Salipante SJ.   +7 more
europepmc   +2 more sources

Ultrasensitive Detection of Chimerism by Single-Molecule Molecular Inversion Probe Capture and High-Throughput Sequencing of Copy Number Deletion Polymorphisms. [PDF]

Clin Chem, 2018
BACKGROUND Genomic chimerism, the co-occurrence of cells from different genetic origins, provides important diagnostic information in diverse clinical contexts, including graft injury detection and longitudinal surveillance of hematopoietic stem cell ...
Wu D, Waalkes A, Penewit K, Salipante SJ.   +3 more
europepmc   +2 more sources

Precise ERBB2 copy number assessment in breast cancer by means of molecular inversion probe array analysis. [PDF]

Oncotarget, 2016
HER2/ERBB2 amplification/overexpression determines the eligibility of breast cancer patients to HER2-targeted therapy. This study evaluates the agreement between ERBB2 copy number assessment by fluorescence in situ hybridization, a standard method ...
Christgen M, van Luttikhuizen JL, Raap M, Braubach P, Schmidt L, Jonigk D, Feuerhake F, Lehmann U, Schlegelberger B, Kreipe HH, Steinemann D.   +10 more
europepmc   +2 more sources

Ultrasensitive Quantitation of Genomic Chimerism by Single-Molecule Molecular Inversion Probe Capture and High-Throughput Sequencing of Copy Number Deletion Polymorphisms. [PDF]

J Mol Diagn, 2022
Wu D, Kanaan SB, Penewit K, Waalkes A, Urselli F, Nelson JL, Radich J, Salipante SJ.   +7 more
europepmc   +2 more sources

Highly multiplexed molecular inversion probe genotyping: Over 10,000 targeted SNPs genotyped in a single tube assay [PDF]

Genome Research, 2005
Large-scale genetic studies are highly dependent on efficient and scalable multiplex SNP assays. In this study, we report the development of Molecular Inversion Probe technology with four-color, single array detection, applied to large-scale genotyping ...
Paul Hardenbol, Fuli Yu, John W. Belmont, Jennifer MacKenzie, Carsten Bruckner, Tiffany Brundage, Andrew Boudreau, Steve Chow, Jim Eberle, Ayça Erbilgin, Mat Falkowski, R.C. Fitzgerald, Sy Ghose, Oleg Iartchouk, Maneesh Jain, George Karlin‐Neumann, Xiuhua Lu, Xin Miao, Bridget Moore, Martin Moorhead, Eugeni Namsaraev, Shiran Pasternak, Eunice Prakash, Karen Tran, Zhiyong Wang, Hywel B. Jones, Ronald W. Davis, T. D. Willis, Richard A. Gibbs   +28 more
openalex   +2 more sources

A molecular inversion probe and sequencing-based microsatellite instability assay for high throughput cancer diagnostics and Lynch syndrome screening [PDF]

bioRxiv, 2018
Background Clinical guidelines recommend microsatellite instability (MSI) and BRAF V600E testing of all colorectal cancers (CRCs) to screen for Lynch syndrome (LS), a hereditary predisposition to cancer.
Richard Gallon, Christine Hayes, Lisa Redford, Ghanim Alhilal, Ottie O’Brien, Amanda Waltham, Stephanie Needham, Mark J. Arends, Anca Oniscu, Ángel Alonso, Sira Moreno Laguna, Harsh Sheth, Mauro Santibanez‐Koref, Michael S. Jackson, John Burn   +14 more
openalex   +2 more sources

Molecular inversion probe-based SPR biosensing for specific, label-free and real-time detection of regional DNA methylation

Chemical Communications, 2014
DNA methylation has the potential to be a clinically important biomarker in cancer. This communication reports a real-time and label-free biosensing strategy for DNA methylation detection in the cancer cell line.
Laura G. Carrascosa, Abu Ali Ibn Sina, Ramkumar Palanisamy, Borja Sepúlveda, Marinus A. Otte, Sakandar Rauf, Muhammad J. A. Shiddiky, Matt Trau   +7 more
openalex   +3 more sources

Allele quantification using molecular inversion probes (MIP) [PDF]

Nucleic Acids Research, 2005
Detection of genomic copy number changes has been an important research area, especially in cancer. Several high-throughput technologies have been developed to detect these changes. Features that are important for the utility of technologies assessing copy number changes include the ability to interrogate regions of interest at the desired density as ...
Yang Wang
openalex   +3 more sources

Comprehensive Screening of Gene Copy Number Aberrations in Formalin-Fixed, Paraffin-Embedded Solid Tumors Using Molecular Inversion Probe–Based Single-Nucleotide Polymorphism Array [PDF]

Journal of Molecular Diagnostics, 2016
Rajesh R. Singh, Meenakshi Mehrotra, Hui Chen, Alaa A. Almohammedsalim, Ayesagul Sahin, Alex Bosamra, Keyur P. Patel, Mark J. Routbort, Xinyan Lu, Ronald Abraham, Bal M. Mishra, Shumaila Virani, L. Jeffrey Medeiros, Rajyalakshmi Luthra   +13 more
openalex   +2 more sources