Results 21 to 30 of about 25,457 (267)

Correction: Evaluation of molecular inversion probe versus TruSeq® custom methods for targeted next-generation sequencing. [PDF]

PLoS ONE, 2021
[This corrects the article DOI: 10.1371/journal.pone.0238467.].
Rowida Almomani, Margherita Marchi, Maurice Sopacua, Patrick Lindsey, Erika Salvi, Bart de Koning, Silvia Santoro, Stefania Magri, Hubert J M Smeets, Filippo Martinelli Boneschi, Rayaz A Malik, Dan Ziegler, Janneke G J Hoeijmakers, Gidon Bönhof, Sulayman Dib-Hajj, Stephen G Waxman, Ingemar S J Merkies, Giuseppe Lauria, Catharina G Faber, Monique M Gerrits, on behalf on the PROPANE Study Group   +20 more
doaj   +2 more sources

Molecular inversion probe assay for allelic quantitation. [PDF]

Methods Mol Biol, 2009
Molecular inversion probe (MIP) technology has been demonstrated to be a robust platform for large-scale dual genotyping and copy number analysis. Applications in human genomic and genetic studies include the possibility of running dual germline genotyping and combined copy number variation ascertainment.
Ji H, Welch K.
europepmc   +6 more sources

Molecular inversion probe analysis detects novel copy number alterations in Ewing sarcoma. [PDF]

Cancer Genet, 2012
Ewing sarcoma (ES) is the second most common bone tumor in children and young adults, with dismal outcomes for metastatic and relapsed disease. To better understand the molecular pathogenesis of ES and to identify new prognostic markers, we used molecular inversion probes (MIPs) to evaluate copy number alterations (CNAs) and loss of heterozygosity (LOH)
Jahromi MS, Putnam AR, Druzgal C, Wright J, Spraker-Perlman H, Kinsey M, Zhou H, Boucher KM, Randall RL, Jones KB, Lucas D, Rosenberg A, Thomas D, Lessnick SL, Schiffman JD.   +14 more
europepmc   +6 more sources

Detection of 16S rRNA and KPC Genes from Complex Matrix Utilizing a Molecular Inversion Probe Assay for Next-Generation Sequencing [PDF]

Scientific Reports, 2018
Targeted sequencing promises to bring next-generation sequencing (NGS) into routine clinical use for infectious disease diagnostics. In this context, upfront processing techniques, including pathogen signature enrichment, must amplify multiple targets of
Christopher P. Stefan, Adrienne T. Hall, Timothy D. Minogue   +2 more
doaj   +2 more sources

Ultrasensitive detection of acute myeloid leukemia minimal residual disease using single molecule molecular inversion probes [PDF]

Haematologica, 2017
The identification of minimal residual disease is the primary diagnostic finding which predicts relapse in patients treated for acute myeloid leukemia. Ultrasensitive detection of minimal residual disease would enable better patient risk stratification ...
Adam Waalkes, Kelsi Penewit, Brent L. Wood, David Wu, Stephen J. Salipante   +4 more
doaj   +2 more sources

High quality copy number and genotype data from FFPE samples using Molecular Inversion Probe (MIP) microarrays [PDF]

BMC Medical Genomics, 2009
Background A major challenge facing DNA copy number (CN) studies of tumors is that most banked samples with extensive clinical follow-up information are Formalin-Fixed Paraffin Embedded (FFPE).
Bondy Melissa, Walther Axel, Warren Robert, Richardson Andrea L, Wang Zhigang C, Moorhead Martin, Zhang Li, Sapolsky Ronald, Karlin-Neumann George, Carlton Victoria EH, Wang Yuker, Sahin Aysegul, Krahe Ralf, Tuna Musaffe, Thompson Patricia A, Spellman Paul T, Gray Joe W, Mills Gordon B, Faham Malek   +18 more
doaj   +2 more sources

Ultrafast probing of isotope-induced explicit symmetry breaking in ethylene [PDF]

Communications Chemistry
Symmetry governs nature’s laws, yet many of the natural phenomena occur due to the breakdown of symmetry. Here, we show how isotope-induced inversion symmetry breaking influences ultrafast photoisomerization processes in ethylene.
Alessandro Nicola Nardi, Alexie Boyer, Yaowei Hu, Vincent Loriot, Franck Lépine, Morgane Vacher, Saikat Nandi   +6 more
doaj   +2 more sources

Allele quantification using molecular inversion probes (MIP) [PDF]

Nucleic Acids Research, 2005
Detection of genomic copy number changes has been an important research area, especially in cancer. Several high-throughput technologies have been developed to detect these changes. Features that are important for the utility of technologies assessing copy number changes include the ability to interrogate regions of interest at the desired density as ...
Yang Wang
openalex   +3 more sources

Analysis of molecular inversion probe performance for allele copy number determination [PDF]

Genome Biology, 2007
AbstractWe have developed a new protocol for using molecular inversion probes to accurately and specifically measure allele copy number. The new protocol provides for significant improvements, including the reduction of input DNA (from 2 μg) by more than 25-fold (to 75 ng total genomic DNA), higher overall precision resulting in one order of magnitude ...
Yuker Wang, Martin Moorhead, George Karlin‐Neumann, Nicholas J. Wang, James Ireland, Steven Lin, Chunnuan Chen, Laura M. Heiser, Koei Chin, Laura J. Esserman, Joe W. Gray, Paul T. Spellman, Malek Faham   +12 more
  +10 more sources

A molecular inversion probe-based next-generation sequencing panel to detect germline mutations in Chinese early-onset colorectal cancer patients. [PDF]

Oncotarget, 2017
Zhang J, Wang X, de Voer RM, Hehir-Kwa JY, Kamping EJ, Weren RDA, Nelen M, Hoischen A, Ligtenberg MJL, Hoogerbrugge N, Yang X, Yang Z, Fan X, Wang L, Liu H, Wang J, Kuiper RP, van Kessel AG.   +17 more
europepmc   +3 more sources