Results 31 to 40 of about 206,828 (101)

Detection of 16S rRNA and KPC Genes from Complex Matrix Utilizing a Molecular Inversion Probe Assay for Next-Generation Sequencing

Scientific Reports, 2018
Targeted sequencing promises to bring next-generation sequencing (NGS) into routine clinical use for infectious disease diagnostics. In this context, upfront processing techniques, including pathogen signature enrichment, must amplify multiple targets of
Christopher P Stefan, Adrienne T. Hall, T. Minogue   +2 more
semanticscholar   +1 more source

Ultrasensitive Detection of Chimerism by Single-Molecule Molecular Inversion Probe Capture and High-Throughput Sequencing of Copy Number Deletion Polymorphisms.

Clinical Chemistry, 2018
BACKGROUND Genomic chimerism, the co-occurrence of cells from different genetic origins, provides important diagnostic information in diverse clinical contexts, including graft injury detection and longitudinal surveillance of hematopoietic stem cell ...
David Wu, A. Waalkes, K. Penewit, S. Salipante   +3 more
semanticscholar   +1 more source

Genomic aberrations in normal tissue adjacent to HER2-amplified breast cancers: field cancerization or contaminating tumor cells? [PDF]

, 2012
Field cancerization effects as well as isolated tumor cell foci extending well beyond the invasive tumor margin have been described previously to account for local recurrence rates following breast conserving surgery despite adequate surgical margins and
Benz, Christopher C, Benz, Stephen C, Eppenberger-Castori, Serenella, Gray, Joe W, Lal, Aseem, Sadanandam, Anguraj, Scott, Gary, Spellman, Paul, Waldman, Fred   +8 more
core   +2 more sources

A Molecular Einstein Ring at z=4.12: Imaging the Dynamics of a Quasar Host Galaxy Through a Cosmic Lens [PDF]

, 2008
We present high-resolution (0.3") Very Large Array (VLA) imaging of the molecular gas in the host galaxy of the high redshift quasar PSS J2322+1944 (z=4.12).
Bertoldi, Frank, Brewer, Brendon J., Carilli, Christopher L., Cox, Pierre, Lewis, Geraint F., Riechers, Dominik A., Walter, Fabian   +6 more
core   +2 more sources

Precise ERBB2 copy number assessment in breast cancer by means of molecular inversion probe array analysis

OncoTarget, 2016
HER2/ERBB2 amplification/overexpression determines the eligibility of breast cancer patients to HER2-targeted therapy. This study evaluates the agreement between ERBB2 copy number assessment by fluorescence in situ hybridization, a standard method ...
M. Christgen, J. L. van Luttikhuizen, M. Raap, P. Braubach, Lars Schmidt, D. Jonigk, F. Feuerhake, U. Lehmann, B. Schlegelberger, H. Kreipe, D. Steinemann   +10 more
semanticscholar   +1 more source

CRISPR/Cas9-induced (CTG⋅CAG)n repeat instability in the myotonic dystrophy type 1 locus: implications for therapeutic genome editing [PDF]

, 2017
Myotonic dystrophy type 1 (DM1) is caused by (CTG⋅CAG)n-repeat expansion within the DMPK gene and thought to be mediated by a toxic RNA gain of function.
André, Laurène M., Cumming, Sarah A., Furling, Denis, Gourdon, Geneviève, Monckton, Darren G., Mouly, Vincent, van Agtmaal, Ellen L., van den Broek, Walther J.A.A., van Kessel, Ingeborg D.G., Wansink, Derick G., Wieringa, Bé, Willemse, Marieke   +11 more
core   +6 more sources

Stringent bounds to spatial variations of the electron-to-proton mass ratio in the Milky Way

, 2009
The ammonia method to probe variations of the electron-to-proton mass ratio, Delta_mu/mu, is applied for the first time to dense prestellar molecular clouds in the Milky Way.
Barrow, Barrow, Blatt, Caselli, Flambaum, Henkel, Hougen, Keto, Khoury, King, Kukolich, Levshakov, M.G. Kozlov, Molaro, Mota, Murphy, Olive, P. Molaro, Pagani, Rathborne, Rehinold, Rosenband, Rosolowsky, S.A. Levshakov, Sakai, Shaw, Srianand, Tafalla, Tafalla, Wendt   +29 more
core   +1 more source

Near-threshold high-order harmonic spectroscopy with aligned molecules

, 2010
We study high-order harmonic generation in aligned molecules close to the ionization threshold. Two distinct contributions to the harmonic signal are observed, which show very different responses to molecular alignment and ellipticity of the driving ...
Botheron, P., Bruner, B. D., Diner, A., Dudovich, N., Mairesse, Y., Pons, B., Raz, O., Shafir, D., Soifer, H.   +8 more
core   +1 more source

On negative higher-order Kerr effect and filamentation

, 2010
As a contribution to the ongoing controversy about the role of higher-order Kerr effect (HOKE) in laser filamentation, we first provide thorough details about the protocol that has been employed to infer the HOKE indices from the experiment.
A. Becker, A. Couairon, A. Dogariu, A. Dubietis, A. Rouzé, A. Talebpour, A. Teleki, A. Vinçotte, B. Lavorel, B. Lavorel, C. Marceau, C. Minhaeng, E. Hertz, F. Rosca-Pruna, G. Fibich, H. Stapelfeldt, J. -P. Wolf, J. Arabat, J. Itatani, J. Kasparian, J. Kasparian, J. Kasparian, J. Kasparian, J. Kasparian, J. R. Lalanne, J.-F. Zhang, L. Bergé, L. Bergé, M. Kolesik, M. Nurhuda, M. Nurhuda, N. Aközbek, O. Faucher, P. B. Corkum, P. Béjot, P. Béjot, P. Béjot, P. Rohwetter, P. Sprangle, R. W. Boyd, S. Henin, S. L. Chin, S. Smolorz, S. Tzortzakis, S. Tzortzakis, T. Seideman, V. Loriot, V. Loriot, V. Loriot, V. Renard, V. Renard, W. Ettoumi, W. Ettoumi, W. Ettoumi, Y. Petit, Y. Petit   +55 more
core   +4 more sources

Do the fundamental constants change with time ?

, 2008
Comparisons between the redshifts of spectral lines from cosmologically-distant galaxies can be used to probe temporal changes in low-energy fundamental constants like the fine structure constant and the proton-electron mass ratio.
Ivanchik A. V., NISSIM KANEKAR, Thompson R. I., van Langevelde H. J., Varshalovich D. A., Wiklind T., Wiklind T.   +6 more
core   +1 more source