Results 31 to 40 of about 155,803 (258)

Bayesian Hierarchical Structured Variable Selection Methods with Application to Molecular Inversion Probe Studies in Breast Cancer [PDF]

, 2014
Lin Zhang, Veerabhadran Baladandayuthapani, Bani K. Mallick, Ganiraju C. Manyam, Patricia A. Thompson, Melissa L. Bondy, Kim‐Anh Do   +6 more
openalex   +2 more sources

Characterizing the pharmacogenome using molecular inversion probes for targeted next-generation sequencing. [PDF]

Pharmacogenomics, 2019
Aim: This study assesses the technical performance and cost of a targeted next-generation sequencing (NGS) multigene pharmacogenetic (PGx) test. Materials & methods: A genetic test was developed for 21 PGx genes using molecular inversion probes to ...
Oscar T. Suzuki, O. Dong, Rachel M Howard, T. Wiltshire   +3 more
semanticscholar   +4 more sources

microDuMIP: target-enrichment technique for microarray-based duplex molecular inversion probes [PDF]

Nucleic Acids Research, 2014
Molecular inversion probe (MIP)-based capture is a scalable and effective target-enrichment technology that can use synthetic single-stranded oligonucleotides as probes. Unlike the straightforward use of synthetic oligonucleotides for low-throughput target capture, high-throughput MIP capture has required laborious protocols to generate thousands of ...
Jung-Ki Yoon, Jinwoo Ahn, Han Sang Kim, Soo Min Han, Hoon Jang, Min Goo Lee, Ji Hyun Lee, Duhee Bang   +7 more
openalex   +5 more sources

TEAL-Seq: targeted expression analysis sequencing [PDF]

mSphere
Metagenome sequencing enables the genetic characterization of complex microbial communities. However, determining the activity of isolates within a community presents several challenges, including the wide range of organismal and gene expression ...
Georgia Doing, Priya Shanbhag, Isaac Bell, Sara Cassidy, Efthymios Motakis, Elizabeth Aiken, Julia Oh, Mark D. Adams   +7 more
doaj   +2 more sources

MON-472 Potentially Pathogenic Variants Identified in Patients with Hypopituitarism by Molecular Inversion Probe Sequencing (MIPS), a New Molecular Approach for Low Cost Gene Panel Sequencing

J Endocr Soc, 2019
Vishnopolska S, Mortensen A, Braslavsky D, Keselman A, Bergada I, Marino R, Ramirez P, Perez Garrido N, Ciaccio M, Di Palma M, Belgorosky A, Marti M, Kitzman J, Camper S, Perez Millan M.   +14 more
europepmc   +2 more sources

Highly multiplex molecular inversion probe panel in Plasmodium falciparum targeting common SNPs approximates whole genome sequencing assessments for selection and relatedness

medRxiv
Karamoko Niaré, Rebecca Crudale, Abebe A. Fola, Neeva Wernsman Young, Victor Asua, Melissa D. Conrad, Pierre Gashema, Anita Ghansah, Stan Hangi, Deus S. Ishengoma, Jean-Baptiste Mazarati, Ayalew Jejaw Zeleke, Philip Rosenthal, Abdoulaye Djimdé, Jonathan J. Juliano, Jeffrey A. Bailey   +15 more
openalex   +2 more sources

SNP typing using molecular inversion probes [PDF]

Forensic Science International: Genetics Supplement Series, 2008
Single nucleotide polymorphism (SNP) typing will be useful in forensic analysis but is limited by the multiplexing capacity of multiple targets in the PCR. A strategy to circumvent this problem can be to use molecular inversion probes (MIPs). MIPs are linear oligonucleotides 70–100 nt in length, with end-segments that are complementary to a target ...
Hanna Edlund, Marie Allen
openalex   +3 more sources

Aligning sequence from molecular inversion probes [PDF]

, 2014
ABSTRACTSummaryMolecular inversion probes (MIP’s) allow efficient enrichment of genomic regions of interest for the purpose of targeted sequencing. To date, there is a paucity of simple-to-use software to align sequences derived from this method. Here, we describe a single program that performs mapping, arm removal, and deduplication before outputting ...
Brent S. Pedersen, Elissa Murphy, Ivana V. Yang, David A. Schwartz   +3 more
openalex   +2 more sources

Exome Survey and Candidate Gene Re-Sequencing Identifies Novel Exstrophy Candidate Genes and Implicates LZTR1 in Disease Formation

Biomolecules, 2023
Background: The bladder exstrophy-epispadias complex (BEEC) is a spectrum of congenital abnormalities that involves the abdominal wall, the bony pelvis, the urinary tract, the external genitalia, and, in severe cases, the gastrointestinal tract as well ...
Ricarda Köllges, Jil Stegmann, Sophia Schneider, Lea Waffenschmidt, Julia Fazaal, Katinka Breuer, Alina C. Hilger, Gabriel C. Dworschak, Enrico Mingardo, Wolfgang Rösch, Aybike Hofmann, Claudia Neissner, Anne-Karolin Ebert, Raimund Stein, Nina Younsi, Karin Hirsch-Koch, Eberhard Schmiedeke, Nadine Zwink, Ekkehart Jenetzky, Holger Thiele, Kerstin U. Ludwig, Heiko Reutter   +21 more
doaj   +1 more source

MIPgen: optimized modeling and design of molecular inversion probes for targeted resequencing [PDF]

Bioinformatics, 2014
Abstract Summary Molecular inversion probes (MIPs) enable cost-effective multiplex targeted gene resequencing in large cohorts. However, the design of individual MIPs is a critical parameter governing the performance of this technology with respect to capture uniformity and specificity.
Evan A. Boyle, Brian J. O’Roak, Beth Martin, Akash Kumar, Jay Shendure   +4 more
openalex   +4 more sources