Results 51 to 60 of about 237,920 (292)

Copy number analysis by low coverage whole genome sequencing using ultra low-input DNA from formalin-fixed paraffin embedded tumor tissue

Genome Medicine, 2016
Unlocking clinically translatable genomic information, including copy number alterations (CNA), from formalin-fixed paraffin-embedded (FFPE) tissue is challenging due to low yields and degraded DNA. We describe a robust, cost-effective low-coverage whole
Tanjina Kader, David L. Goode, Stephen Q. Wong, Jacquie Connaughton, Simone M. Rowley, Lisa Devereux, David Byrne, Stephen B. Fox, Gisela Mir Arnau, Richard W. Tothill, Ian G. Campbell, Kylie L. Gorringe   +11 more
doaj   +1 more source

HemoMIPs-Automated analysis and result reporting pipeline for targeted sequencing data.

PLoS Computational Biology, 2020
Targeted sequencing of genomic regions is a cost- and time-efficient approach for screening patient cohorts. We present a fast and efficient workflow to analyze highly imbalanced, targeted next-generation sequencing data generated using molecular ...
Philip Kleinert, Beth Martin, Martin Kircher   +2 more
doaj   +1 more source

Clonal hematopoiesis in the donor does not adversely affect long-term outcomes following allogeneic hematopoietic stem cell transplantation: result from a 13-year follow-up

Haematologica, 2023
Donor clonal hematopoiesis may be transferred to the recipient through allogeneic hematopoietic stem cell transplantation (HSCT), but the potential for adverse long-term impact on transplant outcomes remains unknown.
Kyoung Ha Kim, TaeHyung Kim, Igor Novitzky-Basso, Hyewon Lee, Youngseok Yoo, Jae-Sook Ahn, Ivan Pasic, Arjun Law, Wilson Lam, Fotios V. Michelis, Armin Gerbitz, Auro Viswabandya, Jeffrey Lipton, Rajat Kumar, Jonas Mattsson, Zhaolei Zhang, Nathali Kaushansky, Yardena Brilon, Noa Chapal-Ilani, Tamir Biezuner, Liran I Shlush, Dennis Dong Hwan Kim   +21 more
doaj   +1 more source

A molecular inversion probe and sequencing-based microsatellite instability assay for high throughput cancer diagnostics and Lynch syndrome screening

bioRxiv, 2018
Background Clinical guidelines recommend microsatellite instability (MSI) and BRAF V600E testing of all colorectal cancers (CRCs) to screen for Lynch syndrome (LS), a hereditary predisposition to cancer.
R. Gallon, Christine Hayes, L. Redford, Ghanim Alhilal, Ottie O'Brien, Amanda Waltham, S. Needham, M. Arends, A. Oniscu, Á. Alonso, Sira Moreno Laguna, H. Sheth, M. Santibanez-Koref, M. Jackson, J. Burn   +14 more
semanticscholar   +1 more source

XUV lasing during strong-field assisted transient absorption in molecules

, 2015
Using ab-initio non-Born-Oppenheimer simulations, we demonstrate amplification of XUV radiation in a high-harmonic generation type process using the example of the hydrogen molecular ion.
Bandrauk, Andre. D., Bredtmann, Timm, Chelkowski, Szczepan, Ivanov, Misha   +3 more
core   +1 more source

Magnetic Field Enhanced Superconductivity in Epitaxial Thin Film WTe2. [PDF]

, 2018
In conventional superconductors an external magnetic field generally suppresses superconductivity. This results from a simple thermodynamic competition of the superconducting and magnetic free energies.
Asaba, Tomoya, Chen, Lu, Laleyan, David, Li, Gang, Li, Lu, Li, Yi, Mi, Zetian, Tinsman, Colin, Wang, Yongjie, Xiang, Ziji, Zhao, Songrui, Zhou, Shangnan   +11 more
core   +2 more sources

Novel molecular aberrations and pathologic findings in a tubulocystic variant of renal cell carcinoma

Indian Journal of Pathology and Microbiology, 2013
Tubulocystic renal cell carcinoma (TRCC) is an indolent type of renal cell carcinoma with a good prognosis based on the limited number of published cases. Herein, we describe the unusual clinical, pathologic and molecular findings in a case of TRCC.
Nikhil A Sangle, Rong Mao, Shashirekha Shetty, Joshua D Schiffman, Christopher Dechet, Lester Layfield, Neeraj Agarwal, Ting Liu   +7 more
doaj   +1 more source

Do the fundamental constants change with time ?

, 2008
Comparisons between the redshifts of spectral lines from cosmologically-distant galaxies can be used to probe temporal changes in low-energy fundamental constants like the fine structure constant and the proton-electron mass ratio.
Ivanchik A. V., NISSIM KANEKAR, Thompson R. I., van Langevelde H. J., Varshalovich D. A., Wiklind T., Wiklind T.   +6 more
core   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Highly multiplexed targeted sequencing strategy for infectious disease surveillance

BMC Biotechnology, 2023
Background Global efforts to characterize diseases of poverty are hampered by lack of affordable and comprehensive detection platforms, resulting in suboptimal allocation of health care resources and inefficient disease control.
Iván Hernández-Neuta, Anastasia Magoulopoulou, Flor Pineiro, Jan Gorm Lisby, Mats Gulberg, Mats Nilsson   +5 more
doaj   +1 more source