Results 61 to 70 of about 237,920 (292)

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Recurrent loss of heterozygosity in 1p36 associated with TNFRSF14 mutations in IRF4 translocation negative pediatric follicular lymphomas

Haematologica, 2013
Pediatric follicular lymphoma is a rare disease that differs genetically and clinically from its adult counterpart. With the exception of pediatric follicular lymphoma with IRF4-translocation, the genetic events associated with these lymphomas have not ...
Idoia Martin-Guerrero, Itziar Salaverria, Birgit Burkhardt, Monika Szczepanowski, Michael Baudis, Susanne Bens, Laurence de Leval, Africa Garcia-Orad, Heike Horn, Jasmin Lisfeld, Shoji Pellissery, Wolfram Klapper, Ilske Oschlies, Reiner Siebert   +13 more
doaj   +1 more source

Comparison of three targeted enrichment strategies on the SOLiD sequencing platform. [PDF]

PLoS ONE, 2011
Despite the ever-increasing throughput and steadily decreasing cost of next generation sequencing (NGS), whole genome sequencing of humans is still not a viable option for the majority of genetics laboratories.
Dale J Hedges, Toumy Guettouche, Shan Yang, Guney Bademci, Ashley Diaz, Ashley Andersen, William F Hulme, Sara Linker, Arpit Mehta, Yvonne J K Edwards, Gary W Beecham, Eden R Martin, Margaret A Pericak-Vance, Stephan Zuchner, Jeffery M Vance, John R Gilbert   +15 more
doaj   +1 more source

Development of a precision oncology single molecule molecular inversion probe (smMIP) panel using a community-consensus approach

, 2018
Clinical targeted sequencing panels are important for identifying actionable variants for cancer patients, however, there are currently no strategies to create impartial and rationally-designed panels to accommodate rapidly growing knowledge within the ...
Erica K. Barnell, A. Waalkes, K. Penewit, Katie M. Campbell, Zachary L. Skidmore, C. Pritchard, T. Fehniger, R. Uppaluri, R. Govindan, M. Griffith, S. Salipante, O. Griffith   +11 more
semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Visualizing quantum entanglement and the EPR paradox during the photodissociation of a diatomic molecule using two ultrashort laser pulses

, 2010
We investigate theoretically the dissociative ionization of a H2+ molecule using two ultrashort laser (pump-probe) pulses. The pump pulse prepares a dissociating nuclear wave packet on an ungerade surface of H2+.
A. Ekert, André D. Bandrauk, J. J. Sakurai, M. Aspelmeyer, Szczepan Chelkowski, V. P. Bykov   +5 more
core   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

12mm line survey of the dense molecular gas towards the W28 field TeV gamma-ray sources [PDF]

, 2010
We present 12mm Mopra observations of dense molecular gas towards the W28 supernova remnant (SNR) field. The focus is on the dense molecular gas towards the TeV gamma-ray sources detected by the H.E.S.S.
A. Kawamura, A. Walsh, Acciari, Acord, Aharonian, Aharonian, Aharonian, Aharonian, Albert, Araudo, Arikawa, B. Nicholas, Barrett, Bergin, Breen, Brogan, Bronfman, Chapmann, Churchwell, Claussen, Codella, Dame, Dame, Draine, Dubner, E. Keto, Faúndez, Feinstein, Frail, Fujita, Fukui, G. Rowell, Gabici, Giuliani, Goldsmith, Goudis, Gómez, Harvey, Hewitt, Ho, Hollenbach, Hollenbach, Hunter, Johnston, Kaspi, Keto, Keto, Keto, Kim, Kim, Klaassen, Kuchar, Lefloch, Liszt, Lockman, Longmore, Lozinskaya, M. G. Burton, MacLaren, Marquez-Lugo, Mizuno, Neufeld, Ott, Ott, Pillai, Protheroe, Reach, Reach, Rho, S. Longmore, Sevenster, Sollins, Stahler, Suzuki, Tafalla, Thompson, Torres, Ungerechts, Velázquez, Walmsley, Walmsley, Walsh, Wood, Y. Fukui, Yusef-Zadeh   +84 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Multiclonal complexity of pediatric acute lymphoblastic leukemia and the prognostic relevance of subclonal mutations

Haematologica, 2020
Genomic studies of pediatric acute lymphoblastic leukemia (ALL) have shown remarkable heterogeneity in initial diagnosis, with multiple (sub)clones harboring lesions in relapse-associated genes.
Željko Antić, Jiangyan Yu, Simon V. van Reijmersdal, Anke van Dijk, Linde Dekker, Wouter H. Segerink, Edwin Sonneveld, Marta Fiocco, Rob Pieters, Peter M. Hoogerbrugge, Frank N. van Leeuwen, Ad Geurts van Kessel, Esme Waanders, Roland P. Kuiper   +13 more
doaj   +1 more source