Results 21 to 30 of about 6,717 (247)

Development of a DNA sensor using a molecular logic gate [PDF]

Journal of Biological Physics, 2013
17 pages, 3 ...
D, Bhattacharjee, Dibyendu, Dey, S, Chakraborty, Syed Arshad, Hussain, S, Sinha   +4 more
openaire   +3 more sources

A Molecular Logic Gate for Developing “AND” Logic Probes and the Application in Hepatopathy Differentiation

ACS Central Science, 2022
Accurate diagnosis and therapy are challenging because most diseases lack a single biomarker that distinguishes them from other disorders. A solution would enhance targeting accuracy by using AND-gated combinations of two disease-associated stimuli.
Mengqi Chen, Chunhong Wang, Zexuan Ding, Hao Wang, Yu Wang, Zhibo Liu   +5 more
openaire   +2 more sources

A Cascaded DNA Nanocircuit for Multi-Signal-Responsive Precision siRNA Delivery in Cancer Therapy. [PDF]

Adv Sci (Weinh)
A cascaded dual‐AND logic DNA nanocircuit is engineered to respond to three tumor‐specific signals in a sequential manner: extracellular acidic pH, membrane‐overexpressed nucleolin (NCL), and intracellular glutathione (GSH). This programmable system selectively releases siPARP1 in glioblastoma (GBM), effectively silencing PARP1 and reversing TMZ ...
Zhao Y, Lan Y, Lee MG, He J, Pan Y, Kim E, Fu X, Jung S, Lu W, Fan J, Chen H, Zhao Y, Xu Y, Kim JS, Zhang C.   +14 more
europepmc   +2 more sources

FDA-Approved Drugs Containing Amide Functionality in the Last Five Years (2021–2025): Pharmaceutical Use, Trends and Synthetic Approaches

Medicines
The amide functional group remains a cornerstone of medicinal chemistry, serving as an indispensable scaffold in the design of modern therapeutics. This review presents an analysis of FDA-approved drugs (small molecules and peptides with MW < 1300 Da ...
Davide Benedetto Tiz
doaj   +1 more source

Molecular Full Adder Based on DNA Strand Displacement

IEEE Access, 2020
A new method, namely DNA strand displacement (DSD), has recently emerged in the field of biocomputing. DSD uses the toehold domain as a starting point to cover the strand in the migration domain.
Wei Xiao, Xinjian Zhang, Zheng Zhang, Congzhou Chen, Xiaolong Shi   +4 more
doaj   +1 more source

Quantum Logic Gates Based on DNAtronics, RNAtronics, and Proteintronics

Advanced Intelligent Systems, 2021
Quantum computers (QCs) adopt an n‐state quantum mechanical system to manipulate the superposition state. However, molecular transistors are not used to build up the quantum logic gate.
Sheh-Yi Sheu, Hua-Yi Hsu, Dah-Yen Yang
doaj   +1 more source

Selenoureas for anion binding as molecular logic gates

Chem. Commun., 2017
The first example of a molecular logic gate based on selenourea/anion host–guest interaction that performs a ternary logic operation using an 1 H-NMR easy to read response output is described here.
Arianna Casula, Paloma Begines, Alexandre Bettoschi, Jose`G. Fernandez-Bolan ̃os, Francesco Isaia, Vito Lippolis, O ́scar Lo ́pez, Giacomo Picci, M. Andrea Scorciapino, Claudia Caltagirone, SCORCIAPINO, MARIANO ANDREA   +10 more
openaire   +3 more sources

Fluorescence-Based Multimodal DNA Logic Gates

Nanomaterials
The use of DNA structures in creating multimodal logic gates bears high potential for building molecular devices and computation systems. However, due to the complex designs or complicated working principles, the implementation of DNA logic gates within ...
Chamika Harshani Algama, Jamil Basir, Kalani M. Wijesinghe, Soma Dhakal   +3 more
doaj   +1 more source

New Water-Soluble Poly(propylene imine) Dendrimer Modified with 4-Sulfo-1,8-naphthalimide Units: Sensing Properties and Logic Gates Mimicking

Sensors, 2023
A new water-soluble poly(propylene imine) dendrimer (PPI) modified with 4-sulfo-1,8-naphthalimid units (SNID) and its related structure monomer analog (SNIM) has been prepared by a simple synthesis.
Awad I. Said, Desislava Staneva, Ivo Grabchev   +2 more
doaj   +1 more source

Engineering calcium signaling of astrocytes for neural–molecular computing logic gates

Scientific Reports, 2021
This paper proposes the use of astrocytes to realize Boolean logic gates, through manipulation of the threshold of $$\hbox {Ca}^{2+}$$ Ca 2 + ion flows between the cells based on the input signals. Through wet-lab experiments that engineer the astrocytes
Michael Taynnan Barros, Phuong Doan, Meenakshisundaram Kandhavelu, Brendan Jennings, Sasitharan Balasubramaniam   +4 more
doaj   +1 more source