Results 181 to 190 of about 5,075,651 (313)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis. [PDF]

Cell
Asami S, Yin C, Fan J, Garza LA, Kalhor R.   +4 more
europepmc   +1 more source

Mt Whelan, Queensland [cartographic material] : Commonwealth Topographic Survey /

, 1960
Provisional ed. Topographic map of Mount Whelan region, Queensland, showing classes of roads, railway and telephone lines, fences, state boundries, watercourses and dams, and windpumps.
Australia. Division of National Mapping.
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells. [PDF]

Elife
Oqua AI, Chao K, El Eid L, Casteller L, Baxter BP, Miguéns-Gómez A, Barg S, Jones B, Bernardino de la Serna J, Rouse SL, Tomas A.   +10 more
europepmc   +2 more sources

Molecular mapping in DNA-PAINT via modified Gaussian Mixture Modeling. [PDF]

Nat Commun
Kowalewski R, Reinhardt SCM, Pachmayr I, Xu S, Masullo LA, Jungmann R.   +5 more
europepmc   +1 more source

Oxidative Damage in Sporadic Colorectal Cancer: Molecular Mapping of Base Excision Repair Glycosylases MUTYH and hOGG1 in Colorectal Cancer Patients. [PDF]

Int J Mol Sci, 2022
Kavec MJ, Urbanova M, Makovicky P, Opattová A, Tomasova K, Kroupa M, Kostovcikova K, Siskova A, Navvabi N, Schneiderova M, Vymetalkova V, Vodickova L, Vodicka P.   +12 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Molecular mapping of QTLs for stripe rust resistance in bread wheat (Triticum aestivum L.). [PDF]

BMC Plant Biol
Sharma R, Kumar S, Prasad P, Kumar U, Yashveer S, Gangwar OP, Udupa S, Sharma I, Tiwari R, Sharma P.   +9 more
europepmc   +1 more source

Helen Springs, Northern Territory [cartographic material] : Commonwealth topographic survey /

, 1961
Provisional ed., rev. Nov. 1960. Topographic map of Helen Springs region, Northern Territory showing classes of roads, railway and telephone lines, mines, post offices, wireless transceivers, windpumps, airports or airfields and landing grounds ...
Australia. Division of National Mapping.
core