Results 71 to 80 of about 512,084 (266)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Conditional QTL Mapping of Sedimentation Volume on Seven Quality Traits in Common Wheat

Journal of Integrative Agriculture, 2013
To evaluate the possible genetic interrelationships between flour components and the sedimentation volume (SD), a doubled haploid (DH) population comprising 168 lines were used to identify the conditional quantitative trait loci (QTLs) for SD in three ...
Zhi-ying DENG, Liang ZHAO, Bin LIU, Kun-pu ZHANG, Jian-sheng CHEN, Hou-lan QU, Cai-ling SUN, Yong-xiang ZHANG, Ji-chun TIAN   +8 more
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

VNTR Polymorphisms in the SLC6A3 Gene and Their Impact on Time Perception and EEG Activity

Bioengineering
Aim: The research examined the relationship between SLC6A3 3′-UTR and intron 8 VNTR polymorphisms and their influence on supra-second time estimation performance and EEG alpha band activity. Material and methods: A total of 178 male participants (aged 18
Francisco Victor Costa Marinho, Silmar Silva Teixeira, Giovanny Rebouças Pinto, Thomaz de Oliveira, France Keiko Nascimento Yoshioka, Hygor Fernandes, Aline Miranda, Bruna Brandão Velasques, Alair Pedro Ribeiro de Souza e Silva, Maurício Cagy, Victor Hugo do Vale Bastos   +10 more
doaj   +1 more source

Role of Molecular Breeding in Genetic Improvement of Pigeonpea

International Journal of Bio-Resource and Stress Management, 2023
Advances in molecular breeding tools and approaches in pigeonpea have allowed addressing many significantly scientific questions that are impossible to do so before.
Santosh Kumar Magadum, Shrishail Duggi, Doddabhimappa Gangapur, S. K. Verma   +3 more
doaj  

MVQTLCIM: composite interval mapping of multivariate traits in a hybrid F1 population of outbred species

BMC Bioinformatics, 2017
Background With the plummeting cost of the next-generation sequencing technologies, high-density genetic linkage maps could be constructed in a forest hybrid F1 population. However, based on such genetic maps, quantitative trait loci (QTL) mapping cannot
Fenxiang Liu, Chunfa Tong, Shentong Tao, Jiyan Wu, Yuhua Chen, Dan Yao, Huogen Li, Jisen Shi   +7 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Molecular maps of myosin.

Seibutsu Butsuri, 1988
Three functionally important sites of myosin head, i.e. ATPase site, actin-binding site and SH1 thiol, were identified in its three-dimensional structure by electron microscopy. These sites were also mapped along primary structures of myosin heavy and light chains by chemical methods such as affinity labeling, chemical crosslinking and "end-label ...
openaire   +2 more sources