Molecular marker systems for detection of genetically engineered micro-organisms in the environment
, 1994 James I. Prosser
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Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Punctual mutations in lipoxygenase sequence expressed in black soybean seed coat
Journal of Seed ScienceLipoxygenase enzymes are relevant in several characteristics of soybean seeds, such as germination performance, storage capacity and tolerance to infection by microorganisms.
Liliane Marcia Mertz +5 more
doaj
Molecular Oncology, EarlyView.This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau +9 more
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Development of a molecular marker for cherry crinkle leaf disease. [PDF]
Mol Hortic, 2023 Wang J +7 more
europepmc +1 more source
Molecular haplotyping of genetic markers 10 kb apart by allele-specific long-range PCR [PDF]
, 1996 S Michalatos-Beloin
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A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
Studies on molecular markers for hemostasis and thrombosis in hemodialysis patients.
, 1991 Tetsuo Shibata +8 more
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Substance P (Neurokinin-1) Receptor Is a Marker of Human Mucosal But Not Peripheral Mononulear Cells: Molecular Quantitation and Localization [PDF]
, 1998 Triona Goode +7 more
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