Results 111 to 120 of about 8,494,354 (311)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Deciphering Metabolic Responses in Traumatic Brain Injury Patients With Different Severity Using 1H NMR-Based Serum Metabolomics

Scientifica
The analysis of metabolites presents a promising opportunity to gain insight into the neuropathophysiology of individuals affected by traumatic brain injury (TBI).
Huan Zhou, Dongdong Sun, Dongmei Wang, Zirui Zhu, Xuelian Hong, Rui Fang, Hua Wang, Minghui Li   +7 more
doaj   +1 more source

Bactericidal Activity of Selenium Nanoparticles Against a Multidrug-Resistant Pathogen: Mechanistic Hypothesis from Exploratory Proteomics

Microorganisms
The antimicrobial resistance crisis necessitates novel therapeutics. Selenium nanoparticles (SeNPs) offer promise, but their precise bactericidal mechanism remains poorly defined.
Nora Elfeky, Jing-Ru Chen, Meng-Xiao Zhu, Jing-Dian Wang, Aya Rizk, Mohammed T. Shaaban, Guoping Zhu   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Plant-derived extracellular vesicle-like nanoparticles: an emerging immunomodulatory strategy for intervertebral disc degeneration

Frontiers in Immunology
Intervertebral disc degeneration (IDD), a leading driver of chronic low back pain, has become a major socioeconomic and public health burden due to its high disability rate and substantial treatment costs.
Taobo Luo, Taobo Luo, Moran Suo, Moran Suo, Shuang Chen, Shuang Chen, Zhengbo Wang, Zhengbo Wang, Xiangze Huo, Xiangze Huo, Zhihao Xu, Zhihao Xu, Minghan Yu, Minghan Yu, Wanting Du, Xin Chen, Zhonghai Li, Zhonghai Li   +17 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Structures and genetic information of control region in mitogenomes of Odonata

Mitochondrial DNA. Part B. Resources
Mitogenome data of Odonata is accumulating and widely used in phylogenetic analysis. However, noncoding regions, especially control region, were usually omitted from the phylogenetic reconstruction.
Bin Jiang, Yu Yao, Jia Li, Jiang Zhang, Yang Sun, Shulin He   +5 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Enhancing homology-directed repair efficiency with HDR-boosting modular ssDNA donor

Nature Communications
Despite the potential of small molecules and recombinant proteins to enhance the efficiency of homology-directed repair (HDR), single-stranded DNA (ssDNA) donors, as currently designed and chemically modified, remain suboptimal for precise gene editing ...
Ying-Ying Jin, Peng Zhang, Le-Le Liu, Xiang Zhao, Xiao-Qing Hu, Si-Zhe Liu, Ze-Kun Li, Qian Liu, Jian-Qiao Wang, De-Long Hao, Zhu-Qin Zhang, Hou-Zao Chen, De-Pei Liu   +12 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source