Results 131 to 140 of about 8,494,354 (311)

Study on the phosphorylation of NAD+-specific isocitrate dehydrogenase in the pathogenic bacteria Stenotrophomonas maltophilia and Xanthomonas sacchari

Journal of Enzyme Inhibition and Medicinal Chemistry
Isocitrate dehydrogenases (IDHs) regulate the distribution of carbon flux between the TCA cycle and glyoxylate shunt through reversible phosphorylation that influences pathogen virulence. Current studies only indicate that NADP+-specific IDHs (NADP-IDHs)
Qian Tian, Yongmei Zhang, Chunxu Pan, Linxiao Wang, Na Qin, Zhen Jiang, Chenxi Li, Zhengyu Cao, Guoping Zhu, Peng Wang   +9 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Biogeography and diversity patterns of abundant and rare bacterial communities in paddy soils along middle and lower Yangtze River

Ecology and Evolution
The middle and lower reaches of the Yangtze River serve as principal rice production bases in China, yet the biodiversity and ecological processes of bacterial communities in paddy soils are not well understood.
Xiancan Zhu, Minghui Hu, Xiaoli Wang, Ya Zhang, Dongsheng Du   +4 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Anchoring of a single molecular rotor and its array on metal surfaces using molecular design and self-assembly [PDF]

, 2010
Functionalizing of single molecules on surfaces has manifested great potential for bottom-up construction of complex devices on a molecular scale.
Li Gao, Hong-Jun Gao, Shi-Xuan Du
core  

The molecular mechanism of hPPARα activation

, 2017
MD simulations were performed to explore the molecular mechanism of hPPARα activation. 11 key residues favouring binding ligands and the movements of helices and loops playing important roles in inducing the active conformation change of hPPARα were ...
Mingtao Ao, Meijuan Fang, Boqun Li, Yuqin Qian, Zhen Wu, Bowen Tang, Kaiqiang Guo   +6 more
core   +1 more source

A new target for treating intervertebral disk degeneration: gut microbes

Frontiers in Microbiology
Intervertebral disk degeneration (IDD) is a common clinical spinal disease and one of the main causes of low back pain (LBP). Generally speaking, IDD is considered a natural degenerative process with age.
Kaizhong Wang, Kaizhong Wang, Xiangyan Liu, Xiangyan Liu, Huagui Huang, Huagui Huang, Moran Suo, Moran Suo, Jinzuo Wang, Jinzuo Wang, Xin Liu, Xin Liu, Jing Zhang, Jing Zhang, Xin Chen, Zhonghai Li, Zhonghai Li, Zhonghai Li   +17 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Research on biomechanical model of muscle fiber based on four-state operating mechanism of molecular motors

, 2015
Mechanism research of myosin molecular motor provides a new way to reveal the microscopic feature of muscle contraction and has become a hot focus in biomechanical fields.
Jiangcheng Chen, He Wang, Zhang, Xiaodong, Wang, He, Xiaodong Zhang, Chen, Jiangcheng   +5 more
core   +1 more source