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Pain: Molecular mechanisms

The Journal of Pain, 2000
Our understanding of chronic inflammatory and neuropathic pain at the molecular and cellular level has developed at an extraordinary rate in recent years. Inflammatory, or neuropathic, neuronal plasticity describes the process by which the neurons involved in pain transmission are converted from a state of normosensitivity to one in which they are ...
M, Costigan, C J, Woolf
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Molecular mechanisms of cellular mechanics

Physical Chemistry Chemical Physics, 2006
Mechanical forces play an essential role in cellular processes as input, output, and signals. Various protein complexes in the cell are designed to handle, transform and use such forces. For instance, proteins of muscle and the extracellular matrix can withstand considerable stretching forces, hearing-related and mechanosensory proteins can transform ...
Mu, Gao   +4 more
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Inherited Thrombocytopenias: Molecular Mechanisms

Seminars in Thrombosis and Hemostasis, 2004
Each megakaryocyte forms 10(3) platelets and 10(11) platelets are replenished daily. The unique and amazing mechanisms that allow megakaryocytes to become giant and polyploid and to release such a large number of platelets are still poorly understood.
BALDUINI CL, SAVOIA, ANNA
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Migraine: New Molecular Mechanisms

The Neuroscientist, 2005
Migraine is an episodic headache disorder affecting more than 10% of the general population. Migraine arises from a primary brain dysfunction that leads to activation and sensitization of the trigeminovascular system. A major incompletely understood issue in the neurobiology of migraine concerns the molecular and cellular mechanisms that underlie the ...
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Understanding molecular structure from molecular mechanics

Journal of Computer-Aided Molecular Design, 2011
Molecular mechanics gives us a well known model of molecular structure. It is less widely recognized that valence bond theory gives us structures which offer a direct interpretation of molecular mechanics formulations and parameters. The electronic effects well-known in physical organic chemistry can be directly interpreted in terms of valence bond ...
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Molecular mechanisms

2017
Abstract The development of the atherosclerotic plaque relies on specific cognate interactions between ligands and receptors with the ability to regulate cell recruitment, inflammatory signalling, and the production of powerful inflammatory and bioactive lipid mediators.
Claudia Monaco, Giuseppina Caligiuri
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Molecular Mechanics

1991
Abstract The earliest reference known to the author on molecular mechanics is to be found in a paper by Andrews (1930), which has to do with vibrational spectroscopy. Andrews indicated that if we really understood the underlying fundamentals in this area, we should be able to calculate all of the kinds of things with which this ...
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