Results 61 to 70 of about 2,356,701 (268)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Cellular and molecular mechanisms of diabetes-mediated disc degeneration

Frontiers in Endocrinology
The aging population and lifestyle changes are contributing to a yearly increase in the incidence of spinal degenerative diseases, which significantly lead to chronic pain, neurological dysfunction, and diminished quality of life, with intervertebral ...
Hui Wang, Hui Wang, Moran Suo, Moran Suo, Kaizhong Wang, Kaizhong Wang, Shuang Chen, Shuang Chen, Xiangyan Liu, Xiangyan Liu, Qiwen Wang, Qiwen Wang, Zhenbo Wang, Zhenbo Wang, Xin Chen, Xin Chen, Zhonghai Li, Zhonghai Li   +17 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Inflammatory macrophage-derived plasminogen activator inhibitor-1 exacerbates inflammation through efferocytosis inhibition

Cell Death Discovery
Plasminogen activator inhibitor-1 (PAI-1) is significantly upregulated during inflammatory responses, and elevated PAI-1 levels are associated with poor prognosis in various diseases.
Abd Aziz Ibrahim, Hiromi Miura, Tomoya Terada, Masaki Kawarada, Nobuo Watanabe, Hiroyuki Hosokawa, Masato Ohtsuka, Toshio Miyata, Takashi Yahata   +8 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Molecular Mechanisms of Dementia

International Journal of Molecular Sciences, 2023
The various forms of dementia and the other neurodegenerative disorders that affect memory, cognition, and behavior have become a public health priority across the developed world [...]
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Deciphering Metabolic Responses in Traumatic Brain Injury Patients With Different Severity Using 1H NMR-Based Serum Metabolomics

Scientifica
The analysis of metabolites presents a promising opportunity to gain insight into the neuropathophysiology of individuals affected by traumatic brain injury (TBI).
Huan Zhou, Dongdong Sun, Dongmei Wang, Zirui Zhu, Xuelian Hong, Rui Fang, Hua Wang, Minghui Li   +7 more
doaj   +1 more source

Bactericidal Activity of Selenium Nanoparticles Against a Multidrug-Resistant Pathogen: Mechanistic Hypothesis from Exploratory Proteomics

Microorganisms
The antimicrobial resistance crisis necessitates novel therapeutics. Selenium nanoparticles (SeNPs) offer promise, but their precise bactericidal mechanism remains poorly defined.
Nora Elfeky, Jing-Ru Chen, Meng-Xiao Zhu, Jing-Dian Wang, Aya Rizk, Mohammed T. Shaaban, Guoping Zhu   +6 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source