Results 61 to 70 of about 8,494,354 (311)
BiologyDiabetes mellitus poses a global health challenge, necessitating natural adjuvants with minimal side effects. The aims of this study were to optimize the concentrations of chromium (Cr), zinc (Zn), and germanium (Ge) in the liquid fermentation media of ...
Zhongyi Yang +8 more
doaj +1 more source
Hexameric and pentameric complexes of the ExbBD energizer in the Ton system
eLife, 2018 Gram-negative bacteria import essential nutrients such as iron and vitamin B12 through outer membrane receptors. This process utilizes proton motive force harvested by the Ton system made up of three inner membrane proteins, ExbB, ExbD and TonB. ExbB and
Saori Maki-Yonekura +6 more
doaj +1 more source
Frontiers in Bioscience-Landmark, 2023 Background: Lung cancer is one of the most serious malignant tumors endangering human health and life. This study focused on evaluating the association between single nucleotide polymorphisms (SNPs) of the glutaminase (GLS) and lung cancer susceptibility
Yuhe Wang +8 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Molecular Mechanisms of Holoprosencephaly
Molecular Genetics and Metabolism, 1999 Holoprosencephaly (HPE) is the most common developmental defect of the forebrain in humans. Several distinct human genes for holoprosencephaly have now been identified. They include Sonic hedgehog (SHH), ZIC2, and SIX3. Many additional genes involved in forebrain development are rapidly being cloned and characterized in model vertebrate organisms ...
D E, Wallis, M, Muenke
openaire +2 more sources
Molecular Mechanism of Epidermal Barrier Dysfunction as Primary Abnormalities
, 2020 Epidermal barrier integrity could be influenced by various factors involved in epidermal cell differentiation and proliferation, cell–cell adhesion, and skin lipids. Dysfunction of this barrier can cause skin disorders, including eczema. Inversely,
Ai-Young Lee
core +1 more source
Population Ecology of Glacier Bacteria from the View of Gene Flow in Cryobacterium
MicroorganismsGlaciers have been proposed as evolutionary hotspots for microbial evolution; however, direct evidence for glacial microbial population formation and genomic loci undergoing selective sweeps remains limited. To address this knowledge gap, we investigated
Jiayu Hu +6 more
doaj +1 more source
Genetic variants in the ITPR2 gene are associated with Kashin‐Beck Disease in Tibetan
Molecular Genetics & Genomic Medicine, 2019 Background Kashin‐Beck Disease (KBD) is a chronic, endemic osteoarthropathy. Inositol 1,4,5‐triphosphate receptor type 2 (ITPR2) gene is involved in chondrocytes.
Xue He +7 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Molecular mechanisms of thermosensation
Folia Pharmacologica Japonica, 2004 We feel a wide range of temperatures spanning from cold to heat. Within this range, temperatures over about 43 degrees C and below about 15 degrees C evoke not only a thermal sensation, but also a feeling of pain. In mammals, six thermosensitive ion channels have been reported, all of which belong to the TRP (transient receptor potential) super family.
openaire +3 more sources