Results 51 to 60 of about 8,494,354 (311)

Kinetic model based on molecular mechanism for action potential [PDF]

, 2011
The Hodgkin-Huxley model for action potentials has been widely used but was not built on a microscopic description of the neuronal membrane. Through molecular dynamics simulations, the molecular mechanism of the channel currents is becoming clear ...
Lizhong Xu
core  

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Molecular mechanism of preconditioning [PDF]

IUBMB Life, 2008
AbstractDuring the last 20 years, since the appearance of the first publication on ischemic preconditioning (PC), our knowledge of this phenomenon has increased exponentially. PC is defined as an increased tolerance to ischemia and reperfusion induced by previous sublethal period ischemia.
Manika, Das, Dipak K, Das
openaire   +2 more sources

The role of FOXO3 polymorphisms in susceptibility to tuberculosis in a Chinese population

Molecular Genetics & Genomic Medicine, 2019
Background Tuberculosis (TB) is a significant worldwide health problem, and is caused by Mycobacteria tuberculosis. Recent studies have suggested that FOXO3 plays vital roles in the risk of immune–related infectious diseases such as TB.
Bo Wang, Yuhe Wang, Li Wang, Xue He, Yongjun He, Mei Bai, Linhao Zhu, Jianwen Zheng, Dongya Yuan, Tianbo Jin   +9 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Low-temperature deposition manufacturing technology: a novel 3D printing method for bone scaffolds

Frontiers in Bioengineering and Biotechnology, 2023
The application of three-dimensional printing technology in the medical field has great potential for bone defect repair, especially personalized and biological repair. As a green manufacturing process that does not involve liquefication through heating,
Tianze Sun, Tianze Sun, Tianze Sun, Jinzuo Wang, Jinzuo Wang, Huagui Huang, Huagui Huang, Xin Liu, Xin Liu, Jing Zhang, Jing Zhang, Wentao Zhang, Wentao Zhang, Honghua Wang, Zhonghai Li, Zhonghai Li   +15 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Molecular mechanisms of fibrinolysis [PDF]

British Journal of Haematology, 2005
SummaryThe molecular mechanisms that finely co‐ordinate fibrin formation and fibrinolysis are now well defined. The structure and function of all major fibrinolytic proteins, which include serine proteases, their inhibitors, activators and receptors, have been characterized.
Gabriela, Cesarman-Maus, Katherine A, Hajjar   +1 more
openaire   +2 more sources

Dynamic control of selectivity in the ubiquitination pathway revealed by an ASP to GLU substitution in an intra-molecular salt-bridge network [PDF]

, 2012
Ubiquitination relies on a subtle balance between selectivity and promiscuity achieved through specific interactions between ubiquitin-conjugating enzymes (E2s) and ubiquitin ligases (E3s).
Bonvin, Alexandre M. J. J., Sjoerd J de Vries, Adrien S. J. Melquiond (122976), H Th Marc Timmers, Alexandre M. J. J. Bonvin (18079), Adrien S J Melquiond, Wijk, Sjoerd van, Alexandre M J J Bonvin, Melquiond, Adrien S. J., Timmers, H. Th. Marc, Sjoerd J. de Vries (110976), H. Th. Marc Timmers (10936), Sjoerd J. L. van Wijk (122975), Vries, Sjoerd J. de, Sjoerd J L van Wijk, van Wijk Sjoerd J. L., de Vries Sjoerd J., Timmers H. Th. Marc, Bonvin Alexandre M. J. J., Melquiond Adrien S. J.   +19 more
core   +1 more source

Structural and Kinetic Views of Molecular Chaperones in Multidomain Protein Folding [PDF]

, 2022
Despite recent developments in protein structure prediction, the process of the structure formation, folding, remains poorly understood. Notably, folding of multidomain proteins, which involves multiple steps of segmental folding, is one of the biggest ...
Soichiro Kawagoe, Koichiro Ishimori, Tomohide Saio, サイオ, トモヒデ, Saio, Tomohide, 80740802, カワゴエ, ソウイチロウ, Ishimori, Koichiro, イシモリ, コウイチロウ, 371222/profile-ja.html, 1188, Kawagoe, Soichiro, 齋尾, 智英   +12 more
core   +1 more source