Results 51 to 60 of about 1,749,054 (354)

Callose homeostasis at plasmodesmata: molecular regulators and developmental relevance [PDF]

, 2014
Plasmodesmata are membrane-lined channels that are located in the plant cell wall and that physically interconnect the cytoplasm and the endoplasmic reticulum (ER) of adjacent cells.
De Storme, Nico, Geelen, Danny
core   +2 more sources

MicroRNA Assisted Gene Regulation in Colorectal Cancer

International Journal of Molecular Sciences, 2019
Colorectal cancer (CRC) is the second-leading cause of cancer death and a major public health problem. Nearly 80% CRC cases are diagnosed after the disease have metastasized and are often too advanced for treatment.
A. Fadaka, A. Pretorius, A. Klein
semanticscholar   +1 more source

Regulatory Mechanism of MicroRNA Expression in Cancer

International Journal of Molecular Sciences, 2020
Altered gene expression is the primary molecular mechanism responsible for the pathological processes of human diseases, including cancer. MicroRNAs (miRNAs) are virtually involved at the post-transcriptional level and bind to 3′ UTR of their target ...
Zainab Ali Syeda, Siu Semar Saratu' Langden, Choijamts Munkhzul, Mihye Lee, S. Song   +4 more
semanticscholar   +1 more source

Nudt21-mediated alternative polyadenylation of MZT1 3′UTR contributes to pancreatic cancer progression

iScience
Summary: Alternative polyadenylation (APA) is an important post-transcriptional regulatory mechanism and is involved in many diseases, but its function and mechanism in regulating pancreatic cancer (PC) pathogenesis remain unclear.
Yu Zhou, Jiabin Yang, Leyi Huang, Chao Liu, Min Yu, Rufu Chen, Quanbo Zhou   +6 more
doaj   +1 more source

PARP-1 regulates DNA repair factor availability. [PDF]

, 2018
PARP-1 holds major functions on chromatin, DNA damage repair and transcriptional regulation, both of which are relevant in the context of cancer. Here, unbiased transcriptional profiling revealed the downstream transcriptional profile of PARP-1 enzymatic
Birbe, Ruth, Brand, Lucas J, Cendon-Florez, Ylenia, Chand, Saswati N., de Leeuw, Renée, Dicker, Adam, MD, PhD, Dylgjeri, Emanuela, Evans, Joseph, Feng, Felix Y, Gallagher, Peter, Gaur, Sanchaika, Gomella, Leonard G, Gordon, Nicolas, Han, Sumin, Huang, Fangjin, Kelly, William Kevin, Knudsen, Beatrice, Knudsen, Karen E, Lallas, Costas D, Leiby, Benjamin E, Mandigo, Amy C., McCann, Jennifer J, McCue, Peter, McNair, Christopher, Parsons, Theodore, Poudel Neupane, Neermala, Raj, Ganesh V, Schiewer, M J, Shafi, Ayesha A, Trabulsi, Edouard J, Visakorpi, Tapio, Zhao, Shuang G   +31 more
core   +2 more sources

ALKBH5-IGF2BP2 axis mediates prostate cancer progression and docetaxel resistance via m6A-stabilized CLSPN RNA

iScience
Summary: Prostate cancer (PCa) often progresses to castration-resistant PCa (CRPC), where docetaxel (DTX) resistance is a major challenge. We investigated the role of the m6A demethylase ALKBH5 in this resistance.
Yutong Chen, Yang Li, Zongzhu Liang, Zhao Yang, Haotian Ren, Wanqing Wei, Yuanjie Niu, Zhiqun Shang   +7 more
doaj   +1 more source

Regulation of reproduction via tight control of gonadotropin hormone levels. [PDF]

, 2018
Mammalian reproduction is controlled by the hypothalamic-pituitary-gonadal axis. GnRH from the hypothalamus regulates synthesis and secretion of gonadotropins, LH and FSH, which then control steroidogenesis and gametogenesis. In females, serum LH and FSH
Coss, Djurdjica
core   +1 more source

Lithium alters expression of RNAs in a type-specific manner in differentiated human neuroblastoma neuronal cultures, including specific genes involved in Alzheimer's disease. [PDF]

, 2019
Lithium (Li) is a medication long-used to treat bipolar disorder. It is currently under investigation for multiple nervous system disorders, including Alzheimer's disease (AD).
Balaraman, Yokesh, Chopra, Nipun, Edenberg, Howard J, Kelsoe, John, Lahiri, Debomoy K, Liu, Yunlong, Maloney, Bryan, Nurnberger, John I   +7 more
core   +3 more sources

Implications of differential transcription start site selection on chronic myeloid leukemia and prostate cancer cell protein expression

iScience, 2022
Summary: The relevance of minor transcription start sites in broad promoters is not well understood. We have studied AGAP2 expression in prostate cancer and chronic myeloid leukemia (CML), showing transcription is initiated from alternative transcription
Arif A. Surani, Keith A. Spriggs, Christoph Ufer, Christos Polytarchou, Cristina Montiel-Duarte   +4 more
doaj   +1 more source

A 5-Enolpyruvylshikimate 3-Phosphate Synthase Functions as a Transcriptional Repressor in Populus. [PDF]

, 2018
Long-lived perennial plants, with distinctive habits of inter-annual growth, defense, and physiology, are of great economic and ecological importance.
Barros-Rios, Jaime, Bryan, Anthony C, Chen, Jin-Gui, Collins, Cassandra, Davis, Mark, DiFazio, Stephen P, Dixon, Richard, Engle, Nancy, Evans, Luke M, Feng, Kai, Gunter, Lee E, Guo, Hao-Bo, Guo, Hong, Jawdy, Sara S, Kalluri, Udaya, Lindquist, Erika, Muchero, Wellington, Payyavula, Raja S, Rodriguez, Miguel, Schmutz, Jeremy, Singan, Vasanth R, Sykes, Robert W, Thompson, Olivia, Tschaplinski, Timothy J, Tuskan, Gerald A, Winkeler, Kim, Xie, Meng, Yee, Kelsey, Zhang, Jin   +28 more
core   +1 more source