Results 41 to 50 of about 1,749,054 (354)
The UPR Transducer IRE1 Promotes Breast Cancer Malignancy by Degrading Tumor Suppressor microRNAs
iScience, 2020 Summary: Dysregulation of inositol-requiring enzyme 1 (IRE1), the primary transducer of Unfolded Protein Response (UPR), has been observed in tumor initiation and progression, but the underlying mechanism remains to be further elucidated.
Kezhong Zhang +7 more
doaj +1 more source
iScience, 2022 Summary: The clinical correlation between adiponectin (APN) signal and hypertrophic scar (HS) remains unclear. Here, we found significantly reduced expression of APN receptors (AdipoR1/2) in HS tissues and derived fibroblasts (HFs), suggesting that HS ...
Jian Zhang +13 more
doaj +1 more source
The Multifaceted Activity of the VirF Regulatory Protein in the Shigella Lifestyle [PDF]
, 2016 Shigella is a highly adapted human pathogen, mainly found in the developing world and causing a severe enteric syndrome. The highly sophisticated infectious strategy of Shigella banks on the capacity to invade the intestinal epithelial barrier and cause ...
Colonna, Bianca +4 more
core +3 more sources
Proteoforms expand the world of microproteins and short open reading frame-encoded peptides
iScience, 2023 Summary: Microproteins and short open reading frame-encoded peptides (SEPs) can, like all proteins, carry numerous posttranslational modifications. Together with posttranscriptional processes, this leads to a high number of possible distinct protein ...
Liam Cassidy +2 more
doaj +1 more source
Molecular mechanisms of regulation of gene expression at hypoxia
Studia Biologica, 2013 Hypoxia is one of powerful inducers of expression of a large group of genes, including genes which control glycolysis, angiogenesis and proliferation supportingcell surviving at low oxygen condition. However, in tumor cells hypoxia was observed at normal oxygen tension condition as a result of its decreased utilization. Moreover, hypoxia is an obligate
D. O. Minchenko +10 more
openaire +3 more sources
Emerging role of nuclear factor erythroid 2-related factor 2 in the mechanism of action and resistance to anticancer therapies [PDF]
, 2019 Nuclear factor E2-related factor 2 (NRF2), a transcription factor, is a master regulator of an array of genes related to oxidative and electrophilic stress that promote and maintain redox homeostasis. NRF2 function is well studied in in vitro, animal and
Deeni, Yusuf Y. +3 more
core +3 more sources
Histone deacetylase 2-mediated deacetylation of the Ribonuclease 1 promoter in inflamed human endothelial cells [PDF]
, 2020 Endothelial cells (ECs) function as protective barrier to separate the blood from the surrounding tissue by conducting crucial roles in regulation and maintenance of vascular homeostasis, such as control of vessel permeability or coagulation.
Bedenbender, Katrin
core +1 more source
iScience, 2022 Summary: Noncoding RNAs are important regulators of mucoinflammatory response, but little is known about the contribution of airway long noncoding RNAs (lncRNAs) in COVID-19. RNA-seq analysis showed a more than 4-fold increased expression of IL-6, ICAM-1,
Dinesh Devadoss +11 more
doaj +1 more source
A modular and extensible RNA-based gene-regulatory platform for engineering cellular function [PDF]
, 2007 Engineered biological systems hold promise in addressing pressing human needs in chemical processing, energy production, materials construction, and maintenance and enhancement of human health and the environment. However, significant advancements in our
Smolke, Christina D., Win, Maung Nyan
core +2 more sources
iScienceSummary: Aldehyde dehydrogenase 1A3 (ALDH1A3) promotes tumor growth, metastasis, and chemoresistance in multiple cancers, including triple-negative breast cancer (TNBC), yet no clinically approved, isoform-selective inhibitors exist.
Maya R. MacLean +16 more
doaj +1 more source