Results 21 to 30 of about 1,749,054 (354)

The metabolic enzyme AdhE controls the virulence of Escherichia coli O157:H7 [PDF]

, 2014
Classical studies have focused on the role that individual regulators play in controlling virulence gene expression. An emerging theme, however, is that bacterial metabolism also plays a key role in this process.
Abernathy, Anders, Baumler, Bergman, Boehm, Booth, Campellone, Chevance, Clark, Coburn, Creek, Echave, Elliott, Emmerson, Frankel, Fukuda, Fukuda, Hansen, Hartland, Hayashi, Hu, Hu, Hueck, Iyoda, Kendall, Kuhn, Mahajan, Massé, Minato, Nataro, Naylor, Noris, Paul, Porter, Rietsch, Rietsch, Ritchie, Ritchie, Roe, Roe, Scheltema, Shevchenko, Smith, Soutourina, Sullivan, Sánchez-Sanmarti, Thao, Tobe, Tree, Turner, Vytvytska, Wang, Wang, Weinert, Wolfe, Wolfe, Wolfe, Zhang, Zhao, Zumbrun   +59 more
core   +2 more sources

Intragenic DNA methylation regulates insect gene expression and reproduction through the MBD/Tip60 complex

iScience, 2021
Summary: DNA methylation is an important epigenetic modification. However, the regulations and functions of insect intragenic DNA methylation remain unknown.
Guanfeng Xu, Hao Lyu, Yangqin Yi, Yuling Peng, Qili Feng, Qisheng Song, Chengcheng Gong, Xuezhen Peng, Subba Reddy Palli, Sichun Zheng   +9 more
doaj   +1 more source

Organization, Transcription, and Regulation in the Animal Genome [PDF]

, 1973
This review concern recent experimental information areas of animal cell molecular biology which are relevant to the mechanism of gene regulation. New data regarding interspersion and clustering of repetitive sequence elements in DNA are considered ...
Britten, Roy J., Davidson, Eric H.
core   +1 more source

Molecular Self-Titration as a Mechanism of Gene Regulation [PDF]

Biophysical Journal, 2016
In systems biology, molecular titration is a mechanism for introducing sensitivity of genetic networks to their regulatory proteins. Since most eukaryotic transcription factors lack chemical control by low-molecular-weight hormones or metabolites, transcription factors have evolved various strategies, such as cooperative DNA binding and sequestering ...
Poon, Gregory M.K., Xhani, Suela, Curtis Stephens, Dominique   +2 more
openaire   +1 more source

Molecular architecture of human polycomb repressive complex 2. [PDF]

, 2012
Polycomb Repressive Complex 2 (PRC2) is essential for gene silencing, establishing transcriptional repression of specific genes by tri-methylating Lysine 27 of histone H3, a process mediated by cofactors such as AEBP2.
Aebersold, Ruedi, Ciferri, Claudio, Herzog, Franz, Lander, Gabriel C, Maiolica, Alessio, Nogales, Eva   +5 more
core   +1 more source

Aging as a consequence of misrepair -- A novel theory of aging [PDF]

, 2009
It is now increasingly realized that the underlying mechanisms which govern aging is a complex interplay of genetic regulation and damage accumulation. Aging as a result of accumulation of ‘faults’ on cellular and molecular levels, has been
Arne Wunderlin, Jicun Wang, Ravi Mahadeva, Thomas Michelitsch   +3 more
core   +4 more sources

Epigenetic and transcriptional regulation of CCL17 production by glucocorticoids in arthritis

iScience, 2023
Summary: Glucocorticoids (GCs) are potent anti-inflammatory agents and are broadly used in treating rheumatoid arthritis (RA) patients, albeit with adverse side effects associated with long-term usage.
Tanya J. Lupancu, Kevin M.C. Lee, Mahtab Eivazitork, Cecil Hor, Andrew J. Fleetwood, Andrew D. Cook, Moshe Olshansky, Stephen J. Turner, Richard de Steiger, Keith Lim, John A. Hamilton, Adrian A. Achuthan   +11 more
doaj   +1 more source

Gene body methylation in cancer: molecular mechanisms and clinical applications

Clinical Epigenetics, 2022
DNA methylation is an important epigenetic mechanism that regulates gene expression. To date, most DNA methylation studies have focussed on CpG islands in the gene promoter region, and the mechanism of methylation and the regulation of gene expression ...
Qi Wang, Fei Xiong, Guanhua Wu, Wenzheng Liu, Jun-sheng Chen, Bing Wang, Yongjun Chen   +6 more
semanticscholar   +1 more source

SOCS1 regulates a subset of NFκB-target genes through direct chromatin binding and defines macrophage functional phenotypes

iScience, 2023
Summary: Suppressor of cytokine signaling-1 (SOCS1) exerts control over inflammation by targeting p65 nuclear factor-κB (NF-κB) for degradation in addition to its canonical role regulating cytokine signaling. We report here that SOCS1 does not operate on
Diego R. Coelho, Flavio R. Palma, Veronica Paviani, Katy M. LaFond, Yunping Huang, Dongmei Wang, Brian Wray, Sridhar Rao, Feng Yue, Marcelo G. Bonini, Benjamin N. Gantner   +10 more
doaj   +1 more source

Molecular medicine of microRNAs: structure, function and implications for diabetes [PDF]

, 2008
MicroRNAs (miRNAs) are a family of endogenous small noncoding RNA molecules, of 19–28 nucleotides in length. In humans, up to 3% of all genes are estimated to encode these evolutionarily conserved sequences.
Duncan, Erica Hennessy, Lorraine O'Driscoll, Offield, Schleicher, Zhou   +5 more
core   +1 more source