Results 11 to 20 of about 1,749,054 (354)

CRISPR/dCas9 Tools: Epigenetic Mechanism and Application in Gene Transcriptional Regulation

International Journal of Molecular Sciences, 2023
CRISPR/Cas9-mediated cleavage of DNA, which depends on the endonuclease activity of Cas9, has been widely used for gene editing due to its excellent programmability and specificity.
Rui Cai, Runyu Lv, Xin’e Shi, Gongshe Yang, Jianjun Jin   +4 more
semanticscholar   +1 more source

Molecular Mechanism and Agricultural Application of the NifA–NifL System for Nitrogen Fixation

International Journal of Molecular Sciences, 2023
Nitrogen–fixing bacteria execute biological nitrogen fixation through nitrogenase, converting inert dinitrogen (N2) in the atmosphere into bioavailable nitrogen.
Wenyao Zhang, Yihang Chen, Keyang Huang, Feng Wang, Z. Mei   +4 more
semanticscholar   +1 more source

Hypoxia re-programs 2′-O-Me modifications on ribosomal RNA

iScience, 2021
Summary: Hypoxia is one of the critical stressors encountered by various cells of the human body under diverse pathophysiologic conditions including cancer and has profound impacts on several metabolic and physiologic processes.
Brandon J. Metge, Sarah C. Kammerud, Hawley C. Pruitt, Lalita A. Shevde, Rajeev S. Samant   +4 more
doaj   +1 more source

Plant HKT Channels: An Updated View on Structure, Function and Gene Regulation

International Journal of Molecular Sciences, 2021
HKT channels are a plant protein family involved in sodium (Na+) and potassium (K+) uptake and Na+-K+ homeostasis. Some HKTs underlie salt tolerance responses in plants, while others provide a mechanism to cope with short-term K+ shortage by allowing ...
Janin Riedelsberger, Julia Miller, Braulio Valdebenito-Maturana, M. Piñeros, W. González, I. Dreyer   +5 more
semanticscholar   +1 more source

Dynamic regulation of P-TEFb by 7SK snRNP is integral to the DNA damage response to regulate chemotherapy sensitivity

iScience, 2022
Summary: Testicular germ cell tumors and closely related embryonal stem cells are exquisitely sensitive to cisplatin, a feature thought to be linked to their pluripotent state and p53 status.
Yin Fang, Yan Wang, Benjamin M. Spector, Xue Xiao, Chao Yang, Ping Li, Yuan Yuan, Ping Ding, Zhi-Xiong Xiao, Peixuan Zhang, Tong Qiu, Xiaofeng Zhu, David H. Price, Qintong Li   +13 more
doaj   +1 more source

Tumor-suppressive role of the musculoaponeurotic fibrosarcoma gene in colorectal cancer

iScience, 2023
Summary: Somatic cell reprogramming using the microRNAs miR-200c, miR-302s, and miR-369s leads to increased expression of cyclin-dependent kinase inhibitors in human colorectal cancer (CRC) cells and suppressed tumor growth. Here, we investigated whether
Hiroaki Itakura, Tsuyoshi Hata, Daisuke Okuzaki, Koki Takeda, Kenji Iso, Yamin Qian, Yoshihiro Morimoto, Tomohiro Adachi, Haruka Hirose, Yuhki Yokoyama, Takayuki Ogino, Norikatsu Miyoshi, Hidekazu Takahashi, Mamoru Uemura, Tsunekazu Mizushima, Takao Hinoi, Masaki Mori, Yuichiro Doki, Hidetoshi Eguchi, Hirofumi Yamamoto   +19 more
doaj   +1 more source

Cooperative RNA degradation stabilizes intermediate epithelial-mesenchymal states and supports a phenotypic continuum

iScience, 2022
Summary: Multiple intermediate epithelial-mesenchymal transition (EMT) states reflecting hybrid epithelial and mesenchymal phenotypes were observed in physiological and pathological conditions.
Benjamin Nordick, Mary Chae-Yeon Park, Vito Quaranta, Tian Hong   +3 more
doaj   +1 more source

Restricting genomic actions of innate immune mediators on fetal hematopoietic progenitor cells

iScience, 2023
Summary: Innate immune signaling protects against pathogens, controls hematopoietic development, and functions in oncogenesis, yet the relationship between these mechanisms is undefined.
Vu L. Tran, Peng Liu, Koichi R. Katsumura, Erin Kim, Bjorn M. Schoff, Kirby D. Johnson, Emery H. Bresnick   +6 more
doaj   +1 more source

Molecular subtyping and characterization of clear cell renal cell carcinoma by tumor differentiation trajectories

iScience, 2023
Summary: Previous bulk RNA sequencing or whole genome sequencing on clear cell renal cell carcinoma (ccRCC) subtyping mainly focused on ccRCC cell origin or the complex tumor microenvironment (TME).
Xiu-wu Pan, Wen-jin Chen, Da Xu, Wen-bin Guan, Lin Li, Jia-xin Chen, Wei-jie Chen, Ke-qin Dong, Jian-qing Ye, Si-shun Gan, Wang Zhou, Xin-gang Cui   +11 more
doaj   +1 more source

Transcription Factor Binding Affinities and DNA Shape Readout

iScience, 2020
Summary: An essential event in gene regulation is the binding of a transcription factor (TF) to its target DNA. Models considering the interactions between the TF and the DNA geometry proved to be successful approaches to describe this binding event ...
Max Schnepf, Marc von Reutern, Claudia Ludwig, Christophe Jung, Ulrike Gaul   +4 more
doaj   +1 more source