Results 1 to 10 of about 1,673,480 (208)

Towards molecular systems biology of gene transcription and regulation [PDF]

Biological Chemistry, 2010
Ten years after the determination of the RNA polymerase 11 structure, the basic mechanism of mRNA synthesis during gene transcription is known. In the future, the initiation and regulation of transcription must be studied with a combination of structural
Patrick Cramer
exaly   +3 more sources

LncRNA MACC1-AS1 associates with DDX5 to modulate MACC1 transcription in breast cancer cells

iScience, 2023
Summary: MACC1 is a master oncogene involved in multiple aspects of cancer metastasis in a broad variety of tumors. However, the molecular mechanism by which MACC1 transcription is regulated remains unclear.
Guiyu Zheng, Yanmei Zhu, Liqun Xu, Shaoying Chen, Xiaona Zhang, Wei Li, Weibin Chen, Yanchun Zhou, Wei Gu   +8 more
doaj   +1 more source

Methylation of the tyrosine hydroxylase gene is dysregulated by cocaine dependence in the human striatum

iScience, 2021
Summary: Cocaine dependence is a chronic, relapsing disorder caused by lasting changes in the brain. Animal studies have identified cocaine-related alterations in striatal DNA methylation; however, it is unclear how methylation is related to cocaine ...
Kathryn Vaillancourt, Gang G. Chen, Laura Fiori, Gilles Maussion, Volodymyr Yerko, Jean-François Théroux, Carl Ernst, Benoit Labonté, Erin Calipari, Eric J. Nestler, Corina Nagy, Naguib Mechawar, Deborah C. Mash, Gustavo Turecki   +13 more
doaj   +1 more source

The molecular mechanisms of Foxp3 gene regulation [PDF]

Seminars in Immunology, 2011
Induction of Foxp3 gene expression and acquisition of regulatory T cell fate is, understandably, a highly controlled process and one which many investigators want to illuminate. In studying the regulation of Foxp3 gene expression, several conserved non-coding regions have been identified and the role of various transcription factors at these sites has ...
Maruyama, Takashi, Konkel, Joanne E; id_orcid 0000-0002-6525-5499, Zamarron, Brian F, Chen, WanJun   +3 more
openaire   +3 more sources

The Il6 -39 kb enhancer containing clustered GATA2- and PU.1-binding sites is essential for Il6 expression in murine mast cells

iScience, 2022
Summary: Mast cells serve as a first-line defense of innate immunity. Interleukin-6 (IL-6) induced by bacterial lipopolysaccharide (LPS) in mast cells plays a crucial role in antibacterial protection.
Shin’ya Ohmori, Jun Takai, Satoshi Uemura, Akihito Otsuki, Tetsuya Mori, Kinuko Ohneda, Takashi Moriguchi   +6 more
doaj   +1 more source

CRISPRe: An innate transcriptional enhancer for endogenous genes in CRISPR-Cas immunity

iScience, 2023
Summary: CRISPR-Cas system has been repurposed to the promising strategy of CRISPR-based transcriptional interference/activation (CRISPRi/CRISPRa) without eliciting DNA breaks that enables Cas complex a block for transcription initiation or elongation ...
Dan Li, Yihong Chen, Fei Huang, Jianmei Wang, Xufeng Li, Yi Yang   +5 more
doaj   +1 more source

Integrative analysis reveals histone demethylase LSD1 promotes RNA polymerase II pausing

iScience, 2022
Summary: Lysine-specific demethylase 1 (LSD1) is well-known for its role in decommissioning enhancers during mouse embryonic stem cell (ESC) differentiation.
Hani Jieun Kim, Pishun Li, Taiyun Kim, Andrew J. Oldfield, Xiaofeng Zheng, Pengyi Yang   +5 more
doaj   +1 more source

Deletion of mdig enhances H3K36me3 and metastatic potential of the triple negative breast cancer cells

iScience, 2022
Summary: In this report, we provide evidence showing diminished expression of the mineral dust-induced gene (mdig), a previously identified oncogenic gene, in human triple negative breast cancer (TNBC).
Chitra Thakur, Yiran Qiu, Qian Zhang, Nicholas J. Carruthers, Miaomiao Yu, Zhuoyue Bi, Yao Fu, Priya Wadgaonkar, Bandar Almutairy, Akimasa Seno, Paul M. Stemmer, Fei Chen   +11 more
doaj   +1 more source

KLF3 Mediates Epidermal Differentiation through the Epigenomic Writer CBP

iScience, 2020
Summary: Impairments in the differentiation process can lead to skin diseases that can afflict ∼20% of the population. Thus, it is of utmost importance to understand the factors that promote the differentiation process. Here we identify the transcription
Jackson Jones, Yifang Chen, Manisha Tiwari, Jingting Li, Ji Ling, George L. Sen   +5 more
doaj   +1 more source

Gene repression through epigenetic modulation by PPARA enhances hepatocellular proliferation

iScience, 2022
Summary: Peroxisome proliferator-activated receptor α (PPARA) is a key mediator of lipid metabolism and inflammation. Activation of PPARA in rodents causes hepatocyte proliferation, but the underlying mechanism is poorly understood. This study focused on
Daisuke Aibara, Shogo Takahashi, Tomoki Yagai, Donghwan Kim, Chad N. Brocker, Moshe Levi, Kimihiko Matsusue, Frank J. Gonzalez   +7 more
doaj   +1 more source