Results 151 to 160 of about 14,308,960 (385)

Molecular Motors Interacting with Their Own Tracks

open access: yes, 2007
Dynamics of molecular motors that move along linear lattices and interact with them via reversible destruction of specific lattice bonds is investigated theoretically by analyzing exactly solvable discrete-state ``burnt-bridge'' models.
A. Y. Morozov   +4 more
core   +1 more source

Molecular mechanisms of antibiotic resistance revisited

open access: yesNature Reviews Microbiology, 2022
Elizabeth M. Darby   +6 more
semanticscholar   +1 more source

Human placenta and trophoblast development: key molecular mechanisms and model systems

open access: yesCellular and Molecular Life Sciences, 2019
Abnormal placentation is considered as an underlying cause of various pregnancy complications such as miscarriage, preeclampsia and intrauterine growth restriction, the latter increasing the risk for the development of severe disorders in later life such
M. Knöfler   +5 more
semanticscholar   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

open access: yesFEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää   +2 more
wiley   +1 more source

Molecular mechanisms of the regulation of ATPase cycle in striated muscle [PDF]

open access: yes, 2007
New data on the molecular mechanism of the regulation of ATPase cycle by troponin-tropomyosin system have been obtained in reconstructed muscle fibers by using the polarized fluorescence technique, which allowed us following the azimuthal movements of ...
Charles S. Redwood   +2 more
core   +1 more source

Molecular mechanisms of ferroptosis and its role in cancer therapy

open access: yesJournal of Cellular and Molecular Medicine, 2019
Ferroptosis is a newly defined programmed cell death process with the hallmark of the accumulation of iron‐dependent lipid peroxides. The term was first coined in 2012 by the Stockwell Lab, who described a unique type of cell death induced by the small ...
Tao Xu   +6 more
semanticscholar   +1 more source

Rewriting the dendritic cell code in cancer—from subset identity to immunotherapeutic design

open access: yesFEBS Letters, EarlyView.
Dendritic cells (DCs) play central roles in cancer immunity but are often subverted by the tumor microenvironment. This review explores the diversity of DC subsets, their functional plasticity, and emerging therapeutic strategies to reprogram DCs for enhanced antitumor responses, including vaccines, in vivo targeting, and DC‐based immunotherapies ...
Estevão Carlos Silva Barcelos   +3 more
wiley   +1 more source

The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency

open access: yesCell Reports, 2020
Summary: PARP inhibitors (PARPi) cause synthetic lethality in BRCA-deficient tumors. Whether specific vulnerabilities to PARPi exist beyond BRCA mutations and related defects in homology-directed repair (HDR) is not well understood. Here, we identify the
Marco Gatti   +4 more
doaj  

Molecular mechanisms of transgenerational epigenetic inheritance

open access: yesNature reviews genetics, 2022
Maximilian H. Fitz-James   +1 more
semanticscholar   +1 more source

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