Results 271 to 280 of about 4,358,128 (358)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Physiology and Molecular Mechanisms of the "Third Fluid Space". [PDF]

J Clin Med
Dull RO, Hahn RG.
europepmc   +1 more source

Molecular mechanism of BASIC PENTACYSTEINE factors (BPCs) and MADS-box transcription factor SVP involved in reproductive development in the model species Arabidopsis thaliana

, 2017
Veronica Gregis, Rosanna Petrella, Andrea Ravasio, Martin M. Kater   +3 more
openalex   +1 more source

Glycosphingolipids in neurodegeneration – Molecular mechanisms, cellular roles, and therapeutic perspectives

Hülsmeier, Andreas J.
openalex   +1 more source

Molecular Mechanisms of Implantation

, 2008
F. DOMINGUEZ, C. SIMON, J. GARCIA-VELASCO   +2 more
openaire   +3 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Hypothesis on CRE Motif Alterations in the SLC6A2 Promoter as a Molecular Mechanism for Hyperadrenergic Postural Orthostatic Tachycardia Syndrome (POTS)

Stazzone, Bianca
openalex   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Inflammation and Cancer: Molecular Mechanisms and Therapeutic Targets. [PDF]

MedComm (2020)
Liu X, Wang Z, Zhu H, Han Y, Ji Q.
europepmc   +1 more source