Results 61 to 70 of about 4,434,811 (291)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
The role of repellents and hydrophobins in Ustilago maydis [PDF]
, 2009 Ustilago maydis is an important model organism to study fungal pathogenicity. U. maydis can grow yeast-like and filamentous. In the latter form this fungus infects maize.
Sub Molecular Microbiology +2 more
core +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
An outer membrane determinant for RNA phage genome entry in Pseudomonas aeruginosa
iScienceSummary: Host range of a phage is determined at the various life cycle stages during phage infection. We reported the limited phage-receptor interaction between the RNA phage, PP7 and its host Pseudomonas aeruginosa strains: PAO1 has susceptible type IV ...
Hee-Won Bae, Shin-Yae Choi, You-Hee Cho
doaj +1 more source
Transport of lipopolysaccharide to the Gram-negative bacterial cell surface [PDF]
, 2015 Lipopolysaccharides (LPS) are major lipidic components of the outer membrane of most Gram-negative bacteria. They form a permeability barrier that protects these bacteria from harmful compounds in the environment.
Tommassen, J.P.M. +5 more
core +2 more sources
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Brucella Melitensis As Causative Agent for Neck Abscess in an Endemic Area
Balkan Medical Journal, 2017 Background: Brucellosis, a zoonotic disease, is very common in the Mediterranean basin and a major concern in livestock areas. We present a rare case of a Brucella-caused abscess in the neck of a stock-breeder in an endemic Greek area. Case Report: A 39-
Styliani Sarrou +4 more
doaj +1 more source
Nonlinear spectral imaging of fungi [PDF]
, 2014 Nonlinear microscopy combined with fluorescence spectroscopy is known as nonlinear spectral imaging microscopy (NLSM). This method provides simultaneously specimen morphology – distinguishing different parts in a tissue – and (auto)fluorescence spectra ...
Sub Molecular Microbiology +2 more
core
FEBS Open Bio, EarlyView.Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata +13 more
wiley +1 more source
Virulence Regulation in Borrelia burgdorferi
MicroorganismsBorrelia burgdorferi, the causative agent of Lyme disease, is the most common vector-borne disease in the United States. Compared with other bacterial pathogens, B. burgdorferi has many unique features.
Sierra George, Zhiming Ouyang
doaj +1 more source