Results 151 to 160 of about 3,245,847 (271)

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Immunogenicity of Adalimumab in Bacterial Molecular Mimicry: In Silico Analysis. [PDF]

JMIR Bioinform Biotechnol
Pachón-Suárez DI, Mejía-Salgado G, Correa O, Sánchez A, Munera M, de-la-Torre A.   +5 more
europepmc   +1 more source

Dual Lineages of Langerhans Cells Cooperate to Restore the Immune Barrier after Skin Injury

Advanced Science, EarlyView.
After skin injury, the epidermal immune barrier is rebuilt by two sources of Langerhans cells. Resident Langerhans cells first move into the wound during re‐epithelialization, guided by CXCR2 signaling. Later, recruited monocytes become long‐lived Langerhans cells.
Axel D. Schmitter‐Sánchez, Nicholas Basista, Sudhanshu Mishra, Hyeri Kim, Audrey Bench, Catherine Matte‐Martone, Min‐Soo Seo, Gun Woo Lee, Sangbum Park   +8 more
wiley   +1 more source

The capping arms race: evolutionary interplay between IFIT proteins and viral molecular mimicry. [PDF]

Mol Biol Rep
González-Hilario S, Zepeda-Cendejas P, Cibrian-Segura ME, Avila-Bonilla RG.   +3 more
europepmc   +1 more source

Molecular Mimicry [PDF]

, 1986
Michael B. A. Oldstone, Abner L. Notkins
openaire   +1 more source

Gαi1/3 Are Essential for BMP2‐Induced Osteogenesis by Bridging BMP Receptors to the Gab1 Signaling Complex

Advanced Science, EarlyView.
The Gαi1/3 protein is a crucial connecting protein closely related to the signal transduction process of bone formation‐related cytokines such as BMP2. Gαi1/3 mediates downstream signaling pathways such as Smads and MAPK by binding to adaptor proteins like Gab1, thereby promoting the osteogenic effect of BMSCs.
Huajian Shan, Chaowen Bai, Yifei Zhu, Chenyang Xu, Sonngtao Li, Qize Sun, Chang She, Jinyu Bai, Cong Cao, Yitian Yang, Xiaozhong Zhou   +10 more
wiley   +1 more source

Molecular mimicry: ecology, evolution, and applications of doppelgänger peptides. [PDF]

Trends Biochem Sci
Koch TL, Robinson SD, Safavi-Hemami H.
europepmc   +1 more source

Deciphering Anti‐Cancer Drug Efficacy Through Nanomechanical Vibrations in Living Gastric Cancer Organoids

Advanced Science, EarlyView.
This study developed an efficacy assessment platform that integrates patient‐derived gastric cancer organoids, atomic force microscopy (AFM)‐based nanomechanical vibration detection, deep learning analysis, and organoid mechanical modeling. It detects picomolar drug effects within 0.1 s signal, achieves 97% classification accuracy, and offers non ...
Ting Zhang, Qiubo Chen, Shihai Lan, Liang Zhu, Shuaiyu Liu, Yan Xia, Yalu Zhang, Hanhui Yao, Yongman Liu, Shangquan Wu, Qingchuan Zhang   +10 more
wiley   +1 more source

Ensemble molecular mimicry correlates with antibody cross-reactivity in proteome-wide studies. [PDF]

Front Immunol
Wrabl JO, Beale J, Fortunato G, Monsalve AVDB, Hilser VJ.   +4 more
europepmc   +1 more source

Nanoparticle‐Mediated Bubble Suppression During Droplet Solidification for Mechanical Reinforcement

Advanced Science, EarlyView.
Nanoparticles mediate droplet solidification by raising nucleation temperature, refining dendrites, and slowing freezing‐front advance, thereby suppressing trapped air bubbles in droplet‐based 3D printing. This strategy reduces bubble volume fraction by ∼35% and increases compressive strength by up to 39%, offering a low‐cost route to stronger printed ...
Runmiao Gao, Xuan Zhang, Mengjie Song, Ronggui Yang, Keke Shao, Jun Shen, Long Zhang, Shuhuai Yao, Yubing Guo, Ruzhu Wang, Christopher Yu Hang Chao   +10 more
wiley   +1 more source