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Does SARS-CoV-2 Trigger Stress-Induced Autoimmunity by Molecular Mimicry? A Hypothesis
Viruses can generate molecular mimicry phenomena within their hosts. Why should severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) not be considered one of these?
F. Cappello+4 more
semanticscholar +1 more source
Escaping Antiangiogenic Therapy: Strategies Employed by Cancer Cells [PDF]
Indexación: Web of ScienceTumor angiogenesis is widely recognized as one of the hallmarks of cancer. Consequently, during the last decades the development and testing of commercial angiogenic inhibitors has been a central focus for both basic and ...
Carrasco-Avino, G+4 more
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Infectious diseases and autoimmunity [PDF]
Introduction: Autoimmunity occurs when the immune system recognizes and attacks host tissue. In addition to genetic factors, environmental triggers (in particular viruses, bacteria and other infectious pathogens) are thought to play a major role in the ...
Deidda, Silvia+3 more
core +1 more source
Sarcoidosis, Cancer and Molecular Mimicry [PDF]
Molecular mimicry seems to be the most important factor for the heterogeneous clinical presentation and the immunopathogenesis of sarcoidosis. Molecular mimicry may occur as a result of altered activity of oncogenes. This can lead to crossed-type mediated body reactions targeting structurally similar sections or regions from the tissue homeostasis ...
Uwe Wollina, Georgi Tchernev
openaire +2 more sources
The impact of antigenic molecular mimicry on anti-cancer T-cell immune response
Individuals are exposed to intracellular pathogens (i.e. viruses and intracellular bacteria) and intestinal microbiota, collectively microorganisms (MOs), which enter the body during the host’s lifetime.
Maria Tagliamonte, Luigi Buonaguro
doaj +1 more source
Decoding the relationship between cow’s milk proteins and development of type 1 diabetes mellitus [PDF]
Objective To analyze in silico the evidence of molecular mimicry between human beta-cell autoantigens and cow’s milk proteins as a potential type 1 diabetes mellitus (T1DM) trigger.
Luís Jesuino de Oliveira Andrade+5 more
doaj +1 more source
T-loop phosphorylation of Arabidopsis CDKA;1 is required for its function and can be partially substituted by an aspartate residue [PDF]
As in other eukaryotes, progression through the cell cycle in plants is governed by cyclin-dependent kinases. Phosphorylation of a canonical Thr residue in the T-loop of the kinases is required for high enzyme activity in animals and yeast.
+7 more
core +2 more sources
Clinical epidemiological studies have reported that viral infections cause autoimmune pathology in humans. Host-pathogen protein sequences and structure-based molecular mimicry cause autoreactive T cells to cross-activate.
Sara Begum+8 more
doaj +1 more source
This Journal recently published two papers describing autoimmune hemolytic anemia (AIHA) associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (1, 2).
F. Angileri+5 more
semanticscholar +1 more source
Current Status of Autoimmune Hepatitis in Japan [PDF]
Autoimmune hepatitis (AIH) is a chronic and progressive disease characterized by histological interface hepatitis, hypergammaglobulinemia, and circulating autoantibodies. Multiple factors, including molecular mimicry, a genetic background including major
Miyake, Yasuhiro, Yamamoto, Kazuhide
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