Structural basis for the inhibition of RecBCD by Gam and its synergistic antibacterial effect with quinolones [PDF]
, 2016 Our previous paper (Wilkinson et al, 2016) used high-resolution cryo-electron microscopy to solve the structure of the Escherichia coli RecBCD complex, which acts in both the repair of double-stranded DNA breaks and the degradation of bacteriophage DNA ...
Aedo +44 more
core +5 more sources
Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barré Syndrome in Brazil. [PDF]
, 2019 Zika virus infection is associated with the development of Guillain-Barré syndrome (GBS), a neurological autoimmune disorder caused by immune recognition of gangliosides and other components at nerve membranes.
Alcantara, Luiz Carlos Junior +7 more
core +1 more source
Decoding the relationship between cow’s milk proteins and development of type 1 diabetes mellitus [PDF]
Archives of Endocrinology and MetabolismObjective To analyze in silico the evidence of molecular mimicry between human beta-cell autoantigens and cow’s milk proteins as a potential type 1 diabetes mellitus (T1DM) trigger.
Luís Jesuino de Oliveira Andrade +5 more
doaj +1 more source
The impact of antigenic molecular mimicry on anti-cancer T-cell immune response
Frontiers in Oncology, 2022 Individuals are exposed to intracellular pathogens (i.e. viruses and intracellular bacteria) and intestinal microbiota, collectively microorganisms (MOs), which enter the body during the host’s lifetime.
Maria Tagliamonte, Luigi Buonaguro
doaj +1 more source
Molecular Mimicry: a Paradigm of Host-Microbe Coevolution Illustrated by Legionella
mBio, 2020 Through coevolution with host cells, microorganisms have acquired mechanisms to avoid the detection by the host surveillance system and to use the cell’s supplies to establish themselves.
S. Mondino, S. Schmidt, C. Buchrieser
semanticscholar +1 more source
Does SARS-CoV-2 Trigger Stress-Induced Autoimmunity by Molecular Mimicry? A Hypothesis
Journal of Clinical Medicine, 2020 Viruses can generate molecular mimicry phenomena within their hosts. Why should severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) not be considered one of these?
F. Cappello +4 more
semanticscholar +1 more source
Pathogens, 2022 Clinical epidemiological studies have reported that viral infections cause autoimmune pathology in humans. Host-pathogen protein sequences and structure-based molecular mimicry cause autoreactive T cells to cross-activate.
Sara Begum +8 more
doaj +1 more source
British Journal of Haematology, 2020 This Journal recently published two papers describing autoimmune hemolytic anemia (AIHA) associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (1, 2).
F. Angileri +5 more
semanticscholar +1 more source
Lack of Evidence for Molecular Mimicry in HIV-Infected Subjects. [PDF]
PLoS ONE, 2015 Previous studies in HIV patients have reported autoantibodies to several human proteins, including erythropoietin (EPO), interferon-α (IFN-α), interleukin-2 (IL-2), and HLA-DR, as potential mediators of anemia or immunosuppression.
Peter D Burbelo +4 more
doaj +1 more source
The small molecule ephrin receptor inhibitor, GLPG1790, Reduces renewal capabilities of cancer stem cells, showing anti-tumour efficacy on preclinical glioblastoma models [PDF]
, 2019 Therapies against glioblastoma (GBM) show a high percentage of failure associated with the survival of glioma stem cells (GSCs) that repopulate treated tumours.
Beirinckx, Filip +15 more
core +2 more sources