Results 91 to 100 of about 6,315,441 (313)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Testing the predictive power of reverse screening to infer drug targets, with the help of machine learning

Communications Chemistry
Estimating protein targets of compounds based on the similarity principle—similar molecules are likely to show comparable bioactivity—is a long-standing strategy in drug research. Having previously quantified this principle, we present here a large-scale
Antoine Daina, Vincent Zoete
doaj   +1 more source

Catalyzing molecular function, modeling templates and example.

, 2012
Catalyzing molecular function, modeling templates and example.
Mordechai Choder (109863), Dov Dori (109865), Judith Somekh (109861)   +2 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A network property necessary for concentration robustness

Nature Communications, 2016
Absolute concentration robustness (ACR), independence of the steady-state concentration of a molecule from the environment, is difficult to predict.
Jeanne M. O. Eloundou-Mbebi, Anika Küken, Nooshin Omranian, Sabrina Kleessen, Jost Neigenfind, Georg Basler, Zoran Nikoloski   +6 more
doaj   +1 more source

Special Issue: “Advanced Research on Molecular Modeling of Protein Structure and Functions”

Recent developments in computer technologies, software and methods have made molecular modeling a powerful tool in experimental studies of biomolecular systems, and in their rational modification [...
Maria G. Khrenova
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Aminoglycoside induced nephrotoxicity: molecular modeling studies of calreticulin-gentamicin complex

, 2011
Gentamicin is a member of aminoglycoside group of broad spectrum antibiotics. It impairs protein synthesis by binding to A site of the 30S subunit of bacterial ribosomes. One of the main side effects of this drug is nephrotoxicity.
Gururao Hariprasad, Rani, Komal, Alagiri Srinivasan, Hariprasad, Gururao, Kumar, Manoj, Kaur, Punit, Manoj Kumar, Komal Rani, Srinivasan, Alagiri, Punit Kaur   +9 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Molecular modeling of zeolites and zeolite-adsorbate systems.

, 1992
Molecular modeling of zeolites and zeolite-adsorbate ...
John B. Nicholas (2292928)
core   +4 more sources