Results 121 to 130 of about 33,280,657 (326)

Author Correction: Visualizing group II intron dynamics between the first and second steps of splicing

Nature Communications, 2022
Jacopo Manigrasso, Isabel Chillón, Vito Genna, Pietro Vidossich, Srinivas Somarowthu, Anna Marie Pyle, Marco De Vivo, Marco Marcia   +7 more
doaj   +1 more source

ProSim: development of a user-friendly molecular modelling package

, 2010
We have developed and tested a user-friendly automated molecular modelling workflow with a web-based interface. The workflow has been tested using protein: drug, enzyme: substrate and lectin: sugar interactions.
Kiss, T., Greenwell, P., Terstyanszky, G., Weingarten, N., Afrough, B., Heindl, H.   +5 more
core  

Rational design, synthesis, biological evaluation and in silico studies of 1,2,3-triazol-1-yl acetamide derivatives as DPP-4 inhibitors to treat type-II diabetes mellitus

Results in Chemistry
Diabetes mellitus (DM), is a chronic metabolic disorder affecting over 830 million individuals worldwide. In this study, we report the design and synthesis of a novel series of compounds (7a-7k) as potential antidiabetic agents.
Vishal Mathur, Ozair Alam, Mukund Jha, Animesh Majumdar, Md Fazlur Rahman, Kailash Chandra, Sandhya Bawa, Nadeem Siddiqui   +7 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Unlocking the potential of experimental evolution to study drug resistance in pathogenic fungi

npj Antimicrobials and Resistance
Exploring the dynamics and molecular mechanisms of antimicrobial drug resistance provides critical insights for developing effective strategies to combat it.
Stef Jacobs, Giorgio Boccarella, Pieter van den Berg, Patrick Van Dijck, Hans Carolus   +4 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Synthesis, experimental and theoretical studies on the inhibition of corrosion of C38 steel in a molar hydrochloric acid solution by bis-5,6-methylbenzimidazole-2-thione

Hybrid Advances
The protection against corrosion by a newly synthesized compound, bis-5,6-methylbenzimidazole-2-thione (MBMS), was assessed using two alternative methods: Potentiodynamic polarization investigation (PDP) and Electrochemical Impedance Spectroscopy (EIS ...
N. Lahrache, S. Jebbari, A. Barhoumi, M. Omari, N. Labjar, H. Nasrellah, S. Lakhloufi, S. El Hajjaji   +7 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source