Results 101 to 110 of about 33,280,657 (326)

Toward a Theoretical Understanding of the Corrosion Inhibitive Performance on Iron Surface by Some Macrocyclic Polyether Compounds Containing 1, 3, 4-thiadiazole Entity

International Journal of Electrochemical Science, 2018
The corrosion inhibitive performance, in acidic medium, of macrocyclic polyether compounds: 1-MCTH, 2-MCTH and their protonated forms, was studied on the basis of their degree of planarity, global and local electronic proprieties as well as their ...
A. Mahsoune, K. Sadik, M. Elalaoui Belghiti, I. Bahadur, A. Aboulmouhajir   +4 more
doaj   +1 more source

Quantitative and logic modelling of gene and molecular networks

Nature reviews genetics, 2015
Behaviours of complex biomolecular systems are often irreducible to the elementary properties of their individual components. Explanatory and predictive mathematical models are therefore useful for fully understanding and precisely engineering cellular ...
N. Le Novère
semanticscholar   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Predicting enantioseparations on polysaccharide-based stationary phases using achiral and chiral molecular descriptors

Journal of Chromatography Open
Achiral and chiral molecular descriptors were used to build models that predict the global retention of chiral molecules on the one hand, and their enantioselectivity, separation and elution sequence on the other.
Pieter De Gauquier, Jordy Peeters, Fardine Ameli, Emmanuelle Lipka, Kenno Vanommeslaeghe, Yvan Vander Heyden, Debby Mangelings   +6 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Molecular modelling of fentanyl analogs

Journal of the Serbian Chemical Society, 2004
Fentanyl is a highly potent and clinically widely used narcotic analgesic. A large number of its analogs have been synthesized, some of which (sufentanil and alfentanyl) are also in clinical use. Theoretical studies, in recent years, afforded a better understanding of the structure-activity relationships of this class of opiates and allowed insight ...
openaire   +3 more sources

Smart desalination systems coupled with green hydrogen production based on IoT [PDF]

BIO Web of Conferences
Keeping water safe and creating clean energy are very important for the future. As cities get bigger, people increase, and the weather changes more, water is becoming harder to find.
Ghailane Ayoub, El-Moustaqim Khadija, Abarkan Ahmed, Boudoudou Dalal, Boutarbouch Mounir, Abrouki Younes, Mabrouki Jamal   +6 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source