Results 171 to 180 of about 163,670 (314)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Multi-epitope vaccine design against human metapneumovirus via reverse vaccinology and molecular modelling. [PDF]

Sci Rep
Bukhari K.
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Molecular Modelling For Beginnrers

, 2003
xi;ill.;410hal ...
Hinchliffe Alan
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Synthesis, in vitro anti-HIV-1 reverse transcriptase evaluation, molecular modelling, DFT analysis and acute oral toxicity assessment of benzotriazole derivatives. [PDF]

Sci Rep
Maiti NJ, Ganguly S, Choowongkomon K, Seetaha S, Saehlee S, Aiebchun T, Ghosh R, Khan MA, Debnath B, Nath R, Ashique S, Singh NK, Ansari MY, Tariq M, Niazi P.   +14 more
europepmc   +1 more source

CryoEM structure and Alphafold molecular modelling of a novel molluscan hemocyanin. [PDF]

PLoS One, 2023
Pasqualetto G, Mack A, Lewis E, Cooper R, Holland A, Borucu U, Mantell J, Davies T, Weckener M, Clare D, Green T, Kille P, Muhlhozl A, Young MT.   +13 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

An Evaluation of the Interaction of Brefeldin A with Mitogen-Activated Protein Kinase 1 (MAPK1) and Protein Kinase C Alpha (PrKCα): Insights from Molecular Modelling Studies. [PDF]

Int J Mol Sci
Naidoo V, Achilonu I, Soobben M, Iwuchukwu E, Singh N, Kandhavelu J, Hull R, Mirza S, Penny C.   +8 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Novel Insights on Benzo[<i>b</i>]thiophene Analogues for MAO-B Inhibition and Neuroprotection: Design, Synthesis, Molecular Modelling Studies and Biological Activity. [PDF]

Antioxidants (Basel)
Arrighi F, Berrino E, Guglielmi P, Carradori S, Marconi GD, Pizzicannella J, Guarnieri S, Tuccinardi T, Poli G, Pepi F, Troiani A, Salvitti C, Di Noi A, Coluccia M, Buttitta G, Pontecorvi V, Granese A, Chimenti P, Secci D, Petzer A, Petzer JP, Diomede F.   +21 more
europepmc   +1 more source