Results 171 to 180 of about 33,280,657 (326)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Synthesis, molecular modelling, and evaluation of new mono- and bis-isoxazolines as antibacterial agents: <i>in vitro</i> and <i>in silico</i> analysis. [PDF]

RSC Adv
Altharawi A, Chagaleti BK, Alamri MA, Riadi Y, Aldakhil T, Moulay Youssef AI, Oubella A, Haggam RA.   +7 more
europepmc   +1 more source

CryoEM structure and Alphafold molecular modelling of a novel molluscan hemocyanin. [PDF]

PLoS One, 2023
Pasqualetto G, Mack A, Lewis E, Cooper R, Holland A, Borucu U, Mantell J, Davies T, Weckener M, Clare D, Green T, Kille P, Muhlhozl A, Young MT.   +13 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Investigating pulmonary neuroendocrine cells in human respiratory diseases with airway models

Disease Models & Mechanisms
Noah Candeli, Talya Dayton
doaj   +1 more source

Design of LNA Analogues Using a Combined Density Functional Theory and Molecular Dynamics Approach for RNA Therapeutics

ACS Omega, 2023
Dikshita Dowerah, Mallikarjunachari V. N. Uppuladinne, Plaban J. Sarma, Nishant Biswakarma, Uddhavesh B. Sonavane, Rajendra R. Joshi, Suvendra K. Ray, Nima D. Namsa, Ramesh Ch. Deka   +8 more
doaj   +1 more source

Molecular Modelling of the Adsorption and Delivery of α-Pinene and Similar Terpenes of Essential Oils on Montmorillonite Surfaces. [PDF]

Nanomaterials (Basel)
Kanwal S, Hernández-Laguna A, Sainz-Díaz CI.   +2 more
europepmc   +1 more source

Novel Antiviral Agents: Synthesis, Molecular Modelling Studies and Biological Investigation. [PDF]

Viruses, 2023
Brogi S.
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Anti-inflammatory effects of 3PO in asthmatic airway inflammation: an integrated study using network pharmacology, molecular modelling, and <i>in vivo</i> experiments. [PDF]

Front Pharmacol
Huang S, Wei S, Luo F, Cheng Y.
europepmc   +1 more source