Results 181 to 190 of about 163,670 (314)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Third Lecture Award on the 33rd Molecular Modelling Workshop 2019

Christina Nutschel from JSC received the "Third Lecture Award" from the Molecular Graphics and Modeling Society - Deutschsprachige Sektion (MGMS-DS) e.V. on the 33rd Molecular Modelling Workshop 2019, Erlangen, Germany, for the talk "Large-scale analysis
Gohlke, Christina
core  

Investigating pulmonary neuroendocrine cells in human respiratory diseases with airway models

Disease Models & Mechanisms
Noah Candeli, Talya Dayton
doaj   +1 more source

Experimental ¹H, ¹³C and T₁ NMR Studies of Graphene Oxide Interactions with 2-Fluorophenylacetic Acid as a Fluorinated Cathinone Model Supported by Molecular Modelling. [PDF]

Molecules
Makieieva N, Jewgiński M, Małolepszy A, Kupka T.   +3 more
europepmc   +1 more source

Design, molecular modelling and synthesis of novel benzothiazole derivatives as BCL-2 inhibitors. [PDF]

Sci Rep, 2023
Ismail HS, Khalil A, Taha RA, Lasheen DS, Abou El Ella DA.   +4 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

In Search of New Drugs: Elucidating the Activity of Structurally Similar Potential Antibiotics Using Molecular Modelling. [PDF]

Molecules
Makieieva N, Kupka T, Lodowski P, Balwierz R, Kasperkiewicz K, Byrski A, Konechna R, Lubenets V.   +7 more
europepmc   +1 more source

Integration of molecular modelling and in vitro studies to inhibit LexA proteolysis. [PDF]

Front Cell Infect Microbiol, 2023
Schuurs ZP, McDonald JP, Croft LV, Richard DJ, Woodgate R, Gandhi NS.   +5 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

In silico identification of prospective p53-MDM2 inhibitors from ASINEX database using a comprehensive molecular modelling approach. [PDF]

Sci Rep
Kotadiya DD, Prajapati A, Patel DA, Thakur P, Nair R, Patel HD.   +5 more
europepmc   +1 more source