Results 101 to 110 of about 2,051,496 (327)

How to Upscale The Kinetics of Complex Microsystems

, 2019
The rate constants of chemical reactions are typically inferred from slopes and intersection points of observed concentration curves. In small systems that operate far below the thermodynamic limit, these concentration profiles become stochastic and such
Kryven, Ivan, Torres-Knoop, Ariana
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Obesity-induced pyroptotic adipocyte death leads to TREM2-dependent macrophage dysfunction and adipose tissue inflammation

iScience
Summary: Triggering receptor expressed on myeloid cells 2 (TREM2) is a key marker of lipid-associated macrophages (LAMs), but its role in adipose tissue homeostasis remains unclear due to conflicting results.
Cheoljun Choi, Junhyuck Lee, Gyeongran Park, Sik Namgoong, Yun-Hee Lee   +4 more
doaj   +1 more source

Hierarchical modeling of molecular energies using a deep neural network

, 2017
We introduce the Hierarchically Interacting Particle Neural Network (HIP-NN) to model molecular properties from datasets of quantum calculations. Inspired by a many-body expansion, HIP-NN decomposes properties, such as energy, as a sum over hierarchical ...
Barros, Kipton, Lubbers, Nicholas, Smith, Justin S.   +2 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Combining degree centrality and betweenness centrality of molecular networks can effectively pinpoint individuals at high risk of HIV transmission within the network

Frontiers in Cellular and Infection Microbiology
IntroductionHIV molecular network technology can identify HIV transmission hotspots and individuals at risk of HIV transmission, facilitating precise and targeted interventions.
Wen Gan, Wen Gan, Wen Gan, Bin Zhao, Bin Zhao, Bin Zhao, Wei Song, Mingming Kang, Mingming Kang, Mingming Kang, Xue Dong, Xin Li, Lu Wang, Jianmin Liu, Haibo Ding, Haibo Ding, Haibo Ding, Zhenxing Chu, Zhenxing Chu, Zhenxing Chu, Lin Wang, Lin Wang, Lin Wang, Wen Tian, Wen Tian, Wen Tian, Hong Shang, Hong Shang, Hong Shang, Xiaoxu Han, Xiaoxu Han, Xiaoxu Han   +31 more
doaj   +1 more source

How Does Lagenaria siceraria (Bottle Gourd) Metabolome Compare to Cucumis sativus (Cucumber) F. Cucurbitaceae? A Multiplex Approach of HR-UPLC/MS/MS and GC/MS Using Molecular Networking and Chemometrics [PDF]

, 2023
Radwa H. El‐Akad, Mohamed G. Sharaf El-Din, Mohamed A. Farag   +2 more
openalex   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

"Two-step" model of molecular diffusion in silicalite [PDF]

, 1999
The influence of the particle "memory" on long-range diffusion in the channel network of silicalite is taken into account by considering pairs of subsequent steps between the channel intersections.
Demontis, Pierfranco, Kärger, Jörg, Suffritti, Giuseppe Baldovino, Tilocca, Antonio   +3 more
core