Results 91 to 100 of about 2,063,348 (292)

Epidemiological dynamics and molecular characterization of HIV drug resistance in eastern China from 2020 to 2023

Frontiers in Microbiology
ObjectiveHIV drug resistance (HIVDR) has become a threat to the elimination of the AIDS epidemic due to the global scale-up of antiretroviral therapy (ART) for HIV-infected individuals.
Min Zhu, Zhou Sun, Xingliang Zhang, Wenjie Luo, Sisheng Wu, Ling Ye, Ke Xu, Junfang Chen   +7 more
doaj   +1 more source

Chemical novelty facilitates herbivore resistance and biological invasions in some introduced plant species

Ecology and Evolution, 2020
Ecological release from herbivory due to chemical novelty is commonly predicted to facilitate biological invasions by plants, but has not been tested on a community scale.
Brian E. Sedio, John L. Devaney, Jamie Pullen, Geoffrey G. Parker, S. Joseph Wright, John D. Parker   +5 more
doaj   +1 more source

Stereo-selective swelling of imprinted cholesteric networks

, 2003
Molecular chirality, and the chiral symmetry breaking of resulting macroscopic phases, can be topologically imprinted and manipulated by crosslinking and swelling of polymer networks.
A. R. Tajbakhsh, C. D. Hasson, E. M. Terentjev, H. Finkelmann, M. Warner, M. A. Osipov, P.-G. de Gennes, P.-G. de Gennes, P.-G. de Gennes, R. Zentel, S. Courty, W. Meier   +11 more
core   +1 more source

Regulatory elements in molecular networks

WIREs Systems Biology and Medicine, 2017
Regulatory elements determine the connectivity of molecular networks and mediate a variety of regulatory processes ranging from DNA looping to transcriptional, posttranscriptional, and posttranslational regulation. This review highlights our current understanding of the different types of regulatory elements found in molecular networks with a focus on ...
Ashley S. Doane, Olivier Elemento
openaire   +3 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Molecular mechanisms driving the microgels behaviour: a Raman spectroscopy and Dynamic Light Scattering study

, 2019
Responsive microgels based on poly(N-isopropylacrylamide) (PNIPAM) exhibit peculiar behaviours due to the competition between the hydrophilic and hydrophobic interactions of the constituent networks. The interpenetration of poly-acrilic acid (PAAc), a pH-
Angelini, Roberta, Bertoldo, Monica, Buratti, Elena, Nigro, Valentina, Postorino, Paolo, Ripanti, Francesca, Ruzicka, Barbara, Sarra, Angelo   +7 more
core   +1 more source

Applications of molecular networks in biomedicine

Biology Methods and Protocols, 2019
Abstract Due to the large interdependence between the molecular components of living systems, many phenomena, including those related to pathologies, cannot be explained in terms of a single gene or a small number of genes. Molecular networks, representing different types of relationships between molecular entities, embody these large ...
Chagoyen, Mónica, Ranea, Juan A. G., Pazos, Florencio   +2 more
openaire   +3 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Obesity-induced pyroptotic adipocyte death leads to TREM2-dependent macrophage dysfunction and adipose tissue inflammation

iScience
Summary: Triggering receptor expressed on myeloid cells 2 (TREM2) is a key marker of lipid-associated macrophages (LAMs), but its role in adipose tissue homeostasis remains unclear due to conflicting results.
Cheoljun Choi, Junhyuck Lee, Gyeongran Park, Sik Namgoong, Yun-Hee Lee   +4 more
doaj   +1 more source

A simple model for the evolution of molecular codes driven by the interplay of accuracy, diversity and cost

, 2008
Molecular codes translate information written in one type of molecules into another molecular language. We introduce a simple model that treats molecular codes as noisy information channels.
Tlusty, Tsvi
core   +1 more source