Results 71 to 80 of about 33,672 (217)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Epidemiological dynamics and molecular characterization of HIV drug resistance in eastern China from 2020 to 2023

Frontiers in Microbiology
ObjectiveHIV drug resistance (HIVDR) has become a threat to the elimination of the AIDS epidemic due to the global scale-up of antiretroviral therapy (ART) for HIV-infected individuals.
Min Zhu, Zhou Sun, Xingliang Zhang, Wenjie Luo, Sisheng Wu, Ling Ye, Ke Xu, Junfang Chen   +7 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Learning and memory in molecular networks [PDF]

Biochemical and Biophysical Research Communications
The present work examines the capacity of biological systems to encode memories via adaptive changes in molecular networks. In single cells, the rewiring of molecular networks can store information as molecular engrams and instantiate learning processes. In multicellular organisms, single cells might communicate with each other and tune their molecular
openaire   +2 more sources

Chemical novelty facilitates herbivore resistance and biological invasions in some introduced plant species

Ecology and Evolution, 2020
Ecological release from herbivory due to chemical novelty is commonly predicted to facilitate biological invasions by plants, but has not been tested on a community scale.
Brian E. Sedio, John L. Devaney, Jamie Pullen, Geoffrey G. Parker, S. Joseph Wright, John D. Parker   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Combining degree centrality and betweenness centrality of molecular networks can effectively pinpoint individuals at high risk of HIV transmission within the network

Frontiers in Cellular and Infection Microbiology
IntroductionHIV molecular network technology can identify HIV transmission hotspots and individuals at risk of HIV transmission, facilitating precise and targeted interventions.
Wen Gan, Wen Gan, Wen Gan, Bin Zhao, Bin Zhao, Bin Zhao, Wei Song, Mingming Kang, Mingming Kang, Mingming Kang, Xue Dong, Xin Li, Lu Wang, Jianmin Liu, Haibo Ding, Haibo Ding, Haibo Ding, Zhenxing Chu, Zhenxing Chu, Zhenxing Chu, Lin Wang, Lin Wang, Lin Wang, Wen Tian, Wen Tian, Wen Tian, Hong Shang, Hong Shang, Hong Shang, Xiaoxu Han, Xiaoxu Han, Xiaoxu Han   +31 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Obesity-induced pyroptotic adipocyte death leads to TREM2-dependent macrophage dysfunction and adipose tissue inflammation

iScience
Summary: Triggering receptor expressed on myeloid cells 2 (TREM2) is a key marker of lipid-associated macrophages (LAMs), but its role in adipose tissue homeostasis remains unclear due to conflicting results.
Cheoljun Choi, Junhyuck Lee, Gyeongran Park, Sik Namgoong, Yun-Hee Lee   +4 more
doaj   +1 more source