Results 51 to 60 of about 8,597,446 (256)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Mining the Metabolome and the Agricultural and Pharmaceutical Potential of Sea Foam-Derived Fungi

Marine Drugs, 2020
Sea foam harbors a diverse range of fungal spores with biological and ecological relevance in marine environments. Fungi are known as the producers of secondary metabolites that are used in health and agricultural sectors, however the potentials of sea ...
Ernest Oppong-Danquah, Cristina Passaretti, Orazio Chianese, Martina Blümel, Deniz Tasdemir   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Epidemiological dynamics and molecular characterization of HIV drug resistance in eastern China from 2020 to 2023

Frontiers in Microbiology
ObjectiveHIV drug resistance (HIVDR) has become a threat to the elimination of the AIDS epidemic due to the global scale-up of antiretroviral therapy (ART) for HIV-infected individuals.
Min Zhu, Zhou Sun, Xingliang Zhang, Wenjie Luo, Sisheng Wu, Ling Ye, Ke Xu, Junfang Chen   +7 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Combining degree centrality and betweenness centrality of molecular networks can effectively pinpoint individuals at high risk of HIV transmission within the network

Frontiers in Cellular and Infection Microbiology
IntroductionHIV molecular network technology can identify HIV transmission hotspots and individuals at risk of HIV transmission, facilitating precise and targeted interventions.
Wen Gan, Wen Gan, Wen Gan, Bin Zhao, Bin Zhao, Bin Zhao, Wei Song, Mingming Kang, Mingming Kang, Mingming Kang, Xue Dong, Xin Li, Lu Wang, Jianmin Liu, Haibo Ding, Haibo Ding, Haibo Ding, Zhenxing Chu, Zhenxing Chu, Zhenxing Chu, Lin Wang, Lin Wang, Lin Wang, Wen Tian, Wen Tian, Wen Tian, Hong Shang, Hong Shang, Hong Shang, Xiaoxu Han, Xiaoxu Han, Xiaoxu Han   +31 more
doaj   +1 more source

Chemical novelty facilitates herbivore resistance and biological invasions in some introduced plant species

Ecology and Evolution, 2020
Ecological release from herbivory due to chemical novelty is commonly predicted to facilitate biological invasions by plants, but has not been tested on a community scale.
Brian E. Sedio, John L. Devaney, Jamie Pullen, Geoffrey G. Parker, S. Joseph Wright, John D. Parker   +5 more
doaj   +1 more source