Results 61 to 70 of about 8,597,446 (256)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Obesity-induced pyroptotic adipocyte death leads to TREM2-dependent macrophage dysfunction and adipose tissue inflammation

iScience
Summary: Triggering receptor expressed on myeloid cells 2 (TREM2) is a key marker of lipid-associated macrophages (LAMs), but its role in adipose tissue homeostasis remains unclear due to conflicting results.
Cheoljun Choi, Junhyuck Lee, Gyeongran Park, Sik Namgoong, Yun-Hee Lee   +4 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Catholic Women's Network, January / February, 2001

, 2001
Digitized version of a newspaper published by the Catholic Women's Network (CWN), a non-profit educational organization for women's spirituality and personal growth.
Catholic Women's Network (Sunnyvale, Calif);
core   +1 more source

Chemical Constituent Analysis of Moringa oleifera Leaves Based on High-Performance Liquid Chromatography-Quadrupole Time-of-Flight Tandem Mass Spectrometry/Mass Spectrometry Combined with Molecular Network Technology

World Journal of Traditional Chinese Medicine
Objective: Moringa oleifera Lam. (M. oleifera) leaves are from a high-economic-value crop and exhibit multiple pharmacological effects, such as hypolipidemic and hypoglycemic activities. However, the studies on the pharmacological basis of M.
Ya-Nan Song, Zhe Jia, Hong-Jun Yang, Yan-Ping Liu, Lin Yan, Javed Iqbal, Yun Wang, Cun Zhang   +7 more
doaj   +1 more source

Catholic Women's Network, November / December, 2000

, 2000
Digitized version of a newspaper published by the Catholic Women's Network (CWN), a non-profit educational organization for women's spirituality and personal growth.
Catholic Women's Network (Sunnyvale, Calif);
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Bioactive oriented discovery of diterpenoids in Coffea arabica basing on 1D NMR and LC-MS/MS molecular network

Beverage Plant Research
Coffee diterpenes are a class of characteristic components in coffee, which have potential biological activities including the prevention of cancer, obesity, diabetes, and other diseases.
Guilin Hu, Chenxi Quan, Abdulbaset Al-Romaima, Haopeng Dai, Minghua Qiu   +4 more
doaj   +1 more source

Catholic Women's Network, September / October, 1995

, 1995
Digitized version of a newspaper published by the Catholic Women's Network (CWN), a non-profit educational organization for women's spirituality and personal growth.
Catholic Women's Network (Sunnyvale, Calif);
core  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source