Results 41 to 50 of about 1,059,427 (119)

Bioactive oriented discovery of diterpenoids in Coffea arabica basing on 1D NMR and LC-MS/MS molecular network

Beverage Plant Research
Coffee diterpenes are a class of characteristic components in coffee, which have potential biological activities including the prevention of cancer, obesity, diabetes, and other diseases.
Guilin Hu, Chenxi Quan, Abdulbaset Al-Romaima, Haopeng Dai, Minghua Qiu   +4 more
doaj   +1 more source

Proteome-wide prediction of the mode of inheritance and molecular mechanisms underlying genetic diseases using structural interactomics

iScience
Summary: Genetic diseases can be classified according to their modes of inheritance and their underlying molecular mechanisms. Autosomal dominant disorders often result from DNA variants that cause loss-of-function, gain-of-function, or dominant-negative
Ali Saadat, Jacques Fellay
doaj   +1 more source

Molecular network characteristics and drug resistance analysis of 392 newly reported MSM HIV/AIDS cases in Chongqing, China

Frontiers in Public Health
To comprehensively investigate the molecular transmission patterns of HIV-1 genotypes among men who have sex with men (MSM) in Chongqing, we employed 392 pol sequences of MSM to construct a phylogenetic tree and gene transmission network. Among the viral
Chongyang Bai, Tianyu Tan, Long Li, Rongrong Lu, Wei Zhang, Ling Ouyang, Guohui Wu, Chao Zhou   +7 more
doaj   +1 more source

Micelle-Containing Hydrogels and Their Applications in Biomedical Research

Gels
Hydrogels are one of the most commonly used materials in our daily lives, which possess crosslinked three-dimensional network structures and are capable of absorbing large amounts of fluid.
Jinghua Wu, Huapeng Li, Nan Zhang, Qingfei Zheng   +3 more
doaj   +1 more source

G-quadruplexes in the proximity 3′-UTR enhances alternative polyadenylation of Neogenin 1

iScience
Summary: Polyadenylation is a crucial step in mRNA maturation. Fifty percent of the time alternative polyadenylation sites (PASs) are used instead of canonical ones, affecting the length of the transcripts’ 3′-UTRs.
Pauline Lejault, François Bolduc, Marc-Antoine Turcotte, Jean Pierre Perreault   +3 more
doaj   +1 more source

Untargeted Metabolomic Profiling and Bioactivity Insights into Alkanna corcyrensis

Scientia Pharmaceutica
This study aimed to characterize the chemical composition and evaluate the biological activities of the aerial parts of Alkanna corcyrensis Hayek (AC), an endemic Greek species not previously studied.
Evgenia Panou, Nikolaos Tsafantakis, Gokhan Zengin, Konstantia Graikou, Christos Ganos, Nikolas Fokialakis, Ioanna Chinou   +6 more
doaj   +1 more source

Rapid Analysis of Compounds from Piperis Herba and Piperis Kadsurae Caulis and Their Differences Using High-Resolution Liquid–Mass Spectrometry and Molecular Network Binding Antioxidant Activity

Molecules
There is a serious mixing of Piperis Herba and Piperis Kadsurae Caulis in various parts of China due to the similar traits of lianas, and there is a lack of systematic research on the compound and activity evaluation of the two. Likewise, the differences
Dezhi Shi, Nanxi Liao, Hualan Liu, Wufeng Gao, Shaohui Zhong, Chao Zheng, Haijie Chen, Lianlian Xiao, Yubo Zhu, Shiwen Huang, Yunyu Zhang, Yang Hu, Yunfeng Zheng, Jing Ji, Jianming Cheng   +14 more
doaj   +1 more source

Molecular footprints of a traveling epidemic: CRF01_AE-cluster 5 (01_C5) might spread across Northeast and South China via middle-aged MSM

Emerging Microbes and Infections
Background HIV-1 CRF01_AE exhibits multiple distinct sub-subtypes (01_C1-C8) with different transmission dynamics across China. Understanding their geographical distribution, transmission patterns, and key affected populations is critical for optimizing ...
Wenxuan Yang, Bin Zhao, Mingming Kang, Minghui An, Wei Song, Xue Dong, Xin Li, Lu Wang, Jianmin Liu, Chenli Zheng, Lin Chen, Hao Li, Yan Zhang, Yongxia Gan, Wen Gan, Hui Zhang, Xiaoxu Han, Jin Zhao, Hong Shang   +18 more
doaj   +1 more source

Editorial: Protein Functional Changes and Signaling Transduction in Cancer Stem Cells

Frontiers in Oncology, 2021
Shihori Tanabe
doaj   +1 more source

The Role of ER Stress in Bilirubin Neurotoxicity: A Complex Molecular Network. [PDF]

Antioxidants (Basel)
Qaisiya M, Tiribelli C, Bellarosa C.
europepmc   +1 more source