Results 41 to 50 of about 33,672 (217)

Molecular Networks in Drug Discovery [PDF]

Critical Reviews™ in Biomedical Engineering, 2010
Despite the dramatic increase of global spending on drug discovery and development, the approval rate for new drugs is declining, due chiefly to toxicity and undesirable side effects. Simultaneously, the growth of available biomedical data in the postgenomic era has provided fresh insight into the nature of redundant and compensatory drug-target ...
John Kenneth, Morrow, Longzhang, Tian, Shuxing, Zhang   +2 more
openaire   +2 more sources

Characteristics and outcomes of diffuse non-midline gliomas with H3F3A gene mutation in the Kansai Molecular Diagnosis Network for CNS Tumors (Kansai Network): multicenter retrospective cohort study

Acta Neuropathologica Communications
Diffuse gliomas with H3F3A gene mutation such as H3.3 K27M and G34R/V are infrequently found in the cerebral hemisphere. These tumors may be called histone H3 K27M-mutant diffuse non-midline gliomas (NDMG) or H3 G34-mutant diffuse hemispheric gliomas ...
Hirokazu Nakatogawa, Junya Fukai, Hiroshi Kawaji, Nobuhide Hayashi, Ema Yoshioka, Yoshinori Kodama, Kosuke Nakajo, Takehiro Uda, Yoshiki Arakawa, Shigeki Takada, Noriyuki Kijima, Kenichi Ishibashi, Takeshi Okuda, Yukihiko Sonoda, Shiro Ohue, Hideyuki Arita, Masahide Matsuda, Tadateru Fukami, Takahiro Tomita, Akihiro Inoue, Takamune Achiha, Hideki Kashiwagi, Daisuke Kanematsu, Asako Katsuma, Miho Sumida, Tomoko Shofuda, Masayuki Mano, Manabu Kinoshita, Kanji Mori, Chikanori Inenaga, Yonehiro Kanemura   +30 more
doaj   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Molecular Networking as a Dereplication Strategy [PDF]

Journal of Natural Products, 2013
A major goal in natural product discovery programs is to rapidly dereplicate known entities from complex biological extracts. We demonstrate here that molecular networking, an approach that organizes MS/MS data based on chemical similarity, is a powerful complement to traditional dereplication strategies.
Yang, Jane Y, Sanchez, Laura M, Rath, Christopher M, Liu, Xueting, Boudreau, Paul D, Bruns, Nicole, Glukhov, Evgenia, Wodtke, Anne, de Felicio, Rafael, Fenner, Amanda, Wong, Weng Ruh, Linington, Roger G, Zhang, Lixin, Debonsi, Hosana M, Gerwick, William H, Dorrestein, Pieter C   +15 more
openaire   +4 more sources

Comparative metabolomic study of fungal foliar endophytes and their long-lived host Astrocaryum sciophilum: a model for exploring the chemodiversity of host-microbe interactions

Frontiers in Plant Science, 2023
IntroductionIn contrast to the dynamics observed in plant/pathogen interactions, endophytic fungi have the capacity to establish enduring associations within their hosts, leading to the development of a mutually beneficial relationship that relies on ...
Leonie Pellissier, Leonie Pellissier, Arnaud Gaudry, Arnaud Gaudry, Salomé Vilette, Salomé Vilette, Nicole Lecoultre, Adriano Rutz, Adriano Rutz, Pierre-Marie Allard, Pierre-Marie Allard, Pierre-Marie Allard, Laurence Marcourt, Laurence Marcourt, Emerson Ferreira Queiroz, Emerson Ferreira Queiroz, Jérôme Chave, Véronique Eparvier, Didier Stien, Katia Gindro, Jean-Luc Wolfender, Jean-Luc Wolfender   +21 more
doaj   +1 more source

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho, Karim M. Soliman, Wisit Cheungpasitporn, Wannasit Wathanavasin, Ahmed Daoud, Ahmed I. Kamal, Balázs Szamosfalvi, Tibor Fülöp   +7 more
wiley   +1 more source

Molecular Beamforming for Actuation in Molecular Communication Networks

IEEE Transactions on NanoBioscience
The actuation accuracy of sensing tasks performed by molecular communication (MC) schemes is a very important metric. Reducing the effect of sensors fallibility can be achieved by improvements and advancements in the sensor and communication networks design.
Joana Angjo, Ali E. Pusane, H. Birkan Yilmaz, Ertugrul Basar, Tuna Tugcu   +4 more
openaire   +3 more sources

Cellulose Functional Gels: Physical Design and Promising Applications

Advanced Physics Research
Cellulose gels, including ionic gels, hydrogels, and aerogels, are 3D, soft polymeric materials known for their excellent properties and designability. As sustainability and green chemistry gain prominence, performance improvement and functional design ...
Minxin Wang, Geyuan Jiang, Xiaoyu Guo, Suqing Zeng, Dawei Zhao   +4 more
doaj   +1 more source

Metabolomics-Guided Discovery of New Dimeric Xanthones from Co-Cultures of Mangrove Endophytic Fungi Phomopsis asparagi DHS-48 and Phomopsis sp. DHS-11

Marine Drugs
The co-culture strategy, which mimics natural ecology by constructing an artificial microbial community, is a useful tool for the activation of biosynthetic gene clusters (BGCs) to generate new metabolites, as well as to increase the yield of respective ...
Jingwan Wu, Dandan Chen, Qing Li, Ting Feng, Jing Xu   +4 more
doaj   +1 more source

Comparative analysis of RNA-Seq data reveals adventitious root development is mediated by ChIFNα in lotus japonicus

Biotechnology & Biotechnological Equipment, 2021
The formation of adventitious roots (ARs) plays an important role in grass growth and production. Chicken alpha interferon (ChIFNα) is an animal glycoprotein with broad activities of immune control, gene induction, growth and development regulation ...
Shimei Yang, Siyu Ma, Riguang Qiu, Qiao Guang, Yun Lv, Yaping Dong, Jiahai Wu, Li Song   +7 more
doaj   +1 more source