Results 101 to 110 of about 2,063,348 (292)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Combining degree centrality and betweenness centrality of molecular networks can effectively pinpoint individuals at high risk of HIV transmission within the network

Frontiers in Cellular and Infection Microbiology
IntroductionHIV molecular network technology can identify HIV transmission hotspots and individuals at risk of HIV transmission, facilitating precise and targeted interventions.
Wen Gan, Wen Gan, Wen Gan, Bin Zhao, Bin Zhao, Bin Zhao, Wei Song, Mingming Kang, Mingming Kang, Mingming Kang, Xue Dong, Xin Li, Lu Wang, Jianmin Liu, Haibo Ding, Haibo Ding, Haibo Ding, Zhenxing Chu, Zhenxing Chu, Zhenxing Chu, Lin Wang, Lin Wang, Lin Wang, Wen Tian, Wen Tian, Wen Tian, Hong Shang, Hong Shang, Hong Shang, Xiaoxu Han, Xiaoxu Han, Xiaoxu Han   +31 more
doaj   +1 more source

How to Upscale The Kinetics of Complex Microsystems

, 2019
The rate constants of chemical reactions are typically inferred from slopes and intersection points of observed concentration curves. In small systems that operate far below the thermodynamic limit, these concentration profiles become stochastic and such
Kryven, Ivan, Torres-Knoop, Ariana
core  

Protein folding and the robustness of cells

, 2007
The intricate intracellular infrastructure of all known life forms is based on proteins. The folded shape of a protein determines both the protein’s function and the set of molecules it will bind to.
Revilla, Ferran D., Tan, G. J. Shawn, Zauner, Klaus-Peter   +2 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Bioactive oriented discovery of diterpenoids in Coffea arabica basing on 1D NMR and LC-MS/MS molecular network

Beverage Plant Research
Coffee diterpenes are a class of characteristic components in coffee, which have potential biological activities including the prevention of cancer, obesity, diabetes, and other diseases.
Guilin Hu, Chenxi Quan, Abdulbaset Al-Romaima, Haopeng Dai, Minghua Qiu   +4 more
doaj   +1 more source

Molecular network of HCC aggressiveness

Oncoscience, 2015
Hepatocellular carcinoma (HCC) is one of the main causes of cancer-related mortality worldwide. It has a poor prognosis due to aggressive phenotype, and limited and insufficient treatment options. In HCCs, acquisition of epithelial mesenchymal transition (EMT) features may account for tumor aggressiveness and chemo-resistance. Many of G protein-coupled
Sang Geon, Kim, Mi Jeong, Heo, Yoon Mee, Yang   +2 more
openaire   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Self-assembling multiblock amphiphiles: Molecular design, supramolecular structure, and mechanical properties

, 2015
We perform off-lattice, canonical ensemble molecular dynamics simulations of the self-assembly of long segmented copolymers consisting of alternating, tunably attractive and hydrophobic {\em binder} domains, connected by hydrophilic {\em linker} chains ...
Mortazavi, Hamed, Storm, Cornelis
core  

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source