Results 261 to 270 of about 4,441,106 (313)

Correction to: Quantitation of PET spatial extent as a potential adjunct to visual interpretation of [¹⁸F]flortaucipir imaging: TAU-SPEX. [PDF]

Eur J Nucl Med Mol Imaging
Coomans EM, van Tol B, Groot C, Smith R, Palmqvist S, Stomrud E, Pontecorvo MJ, Shcherbinin S, Kennedy I, Kotari V, van der Flier WM, Pijnenburg YAL, Mattsson-Carlgren N, Hansson O, van de Giessen E, Ossenkoppele R.   +15 more
europepmc   +1 more source

A COMPREHENSIVE REVIEW ON UNRAVELLING THE INTRICACIES OF MOLECULAR NEUROSCIENCE

Sri Laasya Tipparaju, Krishna Keerthika Oruganti, Laasya Priya Perumahanthi, Geethika Lakshmi Nimmagadda, Lakshmi Sravani Karangula, Siva Naga Mani Soma, Reethika Singh Ranwas   +6 more
openalex   +1 more source

Pathogenicity of Mediator Complex Subunit 27 (MED27) in a Neurodevelopmental Disorder with Cerebellar Atrophy

Advanced Science, EarlyView.
MED27 is one of the 26 subunits in the human Mediator complex (MED). Neurodevelopmental disorder‐causing MED27 genetic variants induce instability of MED, leading to disrupted DNA occupancy, altered chromatin interaction, and subsequent transcriptional dysregulation of critical downstream genes, including master regulatory transcription factors ...
Nuermila Yiliyaer, Xiaocheng Li, Tianyu Guo, Haiying Zhou, Lihai Gong, Luowei Yuan, Yang Fu, Yulong Qiao, Ying Lam Lui, Nuo Chen, Pengfei Lin, Hoi Hung Cheung, Ho Ko, Linyan Meng, Xiao Chen, Yong Lei, Kin Ming Kwan, Huating Wang, Shen Gu   +18 more
wiley   +1 more source

Correction: S-9-PAHSA ameliorates cognitive decline in a type 2 diabetes mouse model by inhibiting oxidative stress and apoptosis via CAIII modulation. [PDF]

Front Mol Neurosci
Wang XR, Huang SS, Wang M, Lin JH, Wang JT, Ren JQ, He CF, Xue WJ, Wang Y, Wang XC, Zhang YL, Xiao JC, Guo JC, Zhou HG.   +13 more
europepmc   +1 more source

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

Correction: Endoglin alleviates neuropathic pain by protecting the blood-spinal cord barrier through the TGF-β/Smad2 signaling pathway. [PDF]

Front Mol Neurosci
Liao S, Zhou FR, Li Q, Jin T, Xiang GF, Wang X, Liu Y, Zhu H, Liu Q, Liu Y, Zhang Y.   +10 more
europepmc   +1 more source

Mechanical Environment Afforded by Engineered Hydrogel Critically Regulates Survival of Neural Stem Cells Transplanted in the Injured Spinal Cord via Piezo1‐Mediated Mechanotransduction

Advanced Science, EarlyView.
Neural stem cell transplantation shows promise for spinal cord repair, but poor graft survival limits therapeutic efficacy. This study demonstrates that increasing hydrogel stiffness from 10% to 16% concentration significantly enhances transplanted neural stem cell survival through Piezo1‐mediated mechanotransduction, revealing mechanical properties as
Hee Hwan Park, Yurim Kim, Byeong Seong Jang, Simay Genişcan, Dong Hoon Hwang, Yeojin Seo, Seung‐Ah Jee, Hyo Gyeong Seo, Hyung Soon Kim, Ariandokht Einisadr, Ho‐Jeong Kim, Seolhee Lee, Sangwoo Kwon, Kyung Sook Kim, Kang In Lee, Jae Young Lee, Joo Min Park, Young‐Min Kim, Soo‐Chang Song, Byung Gon Kim   +19 more
wiley   +1 more source

Editorial: Bridging Inflammation, Oxidative Stress, and Metabolic Dysfunction in Brain Disorders. [PDF]

Brain Sci
Akhtar A.
europepmc   +1 more source

Diagnosis, Prognosis, and Drug Target Discovery for Chronic Widespread Pain: A Large Proteogenomic Study

Advanced Science, EarlyView.
Plasma proteomics is leveraged to decode the biological underpinnings of chronic widespread pain. A nested machine learning framework integrates proteomic signatures, prospective outcomes, and Mendelian randomization to uncover 18 causal proteins.
Li Chen, Eoin Kelleher, Ruogu Meng, Duanke Liu, Yuchen Guo, Yunhe Wang, Yaqing Gao, Zhe Huang, Zhu Liang, Shuai Yuan, Chao Zeng, Jun Ma, Yanhui Dong, Anushka Irani, Guanghua Lei, Junqing Xie, Daniel Prieto‐Alhambra   +16 more
wiley   +1 more source

Correction: Characterization of the role of the antioxidant proteins Metallothioneins 1 and 2 in an animal model of alzheimer's disease. [PDF]

Cell Mol Life Sci
Manso Y, Carrasco J, Comes G, Adlard PA, Bush AI, Hidalgo J.   +5 more
europepmc   +1 more source