Results 111 to 120 of about 5,401,847 (247)

Multi-skill resource-constrained project scheduling problem: a case study in an open-pit mining process

In this article, a case study is analysed using an adaptation of a project scheduling problem with multitasking resource restrictions. The objective is to reduce the operational costs of an open-pit mining process that uses mobile surface equipment, by ...
Solano-Charris E.L., Wiest-Goyeneche J.R., Vega-Mejía C.A.   +2 more
core   +1 more source

ESTIMADORES DE FRONTERA PARA LOS SUPUESTOS CLÚSTERES CONSECUTIVOS DE ÓPTIMO POTENCIAL GLOBAL

Avances en Ciencias e Ingeniería, 2023
For the first time, frontiers estimators are presented for consecutive clusters of particles that possibly correspond to global potential minima where the potential has a behavior of linear change with respect to the number of particles (either of ...
Carlos Barrón-Romero
doaj  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Stress-constrained topology optimization using the constrained natural element method [PDF]

This paper presents a topology optimization framework to achieve volume minimization with Crossland fatigue constraints under proportional loading using the Constrained Natural Element Method.
CHEN, Yanda, MONTEIRO, Eric, Monteiro, E., FAVIER, Véronique, KOUTIRI, Imade   +4 more
core   +1 more source

Molecular optimization by capturing chemist's intuition using deep neural networks. [PDF]

J Cheminform, 2021
He J, You H, Sandström E, Nittinger E, Bjerrum EJ, Tyrchan C, Czechtizky W, Engkvist O.   +7 more
europepmc   +1 more source

Fragment-Masked Molecular Optimization [PDF]

Molecular optimization is a crucial aspect of drug discovery, aimed at refining molecular structures to enhance drug efficacy and minimize side effects, ultimately accelerating the overall drug development process.
Wu, Jia, Li, Kun, Hu, Wenbin, Cai, Xiantao, Du, Bo   +4 more
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Modular and Molecular Optimization of a LOV (Light-Oxygen-Voltage)-Based Optogenetic Switch in Yeast. [PDF]

Int J Mol Sci, 2021
Romero A, Rojas V, Delgado V, Salinas F, Larrondo LF.   +4 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source