Results 101 to 110 of about 5,401,847 (247)

Multiobjective Molecular Optimization for Opioid Use Disorder Treatment Using Generative Network Complex. [PDF]

J Med Chem, 2023
Feng H, Wang R, Zhan CG, Wei GW, Wei GW.
europepmc   +1 more source

Empipe™ User’s Manual Version 4.0 -- PC

, 1997
Empipe is a powerful and friendly software system for automated electromagnetic (EM) design optimization, driving the EM simulator em. Empipe allows you to designate geometrical and material parameters as candidate variables for optimization in an ...
Bandler, John W., Biernacki, R.M., Chen, S.H., Optimization Systems Associates   +3 more
core   +1 more source

Genetic and transcriptomic analyses of early-onset colon cancer (EOCC): a post hoc analysis of 2973 patients from two adjuvant randomized trials

ESMO Gastrointestinal Oncology
Background: Despite decreasing colon cancer (CC) incidence worldwide, an inverse trend is being registered since the late 1990s in people
A. Gandini, C. Gallois, H. Blons, C. Mulot, N. Agueeff, C. Lepage, R. Guimbaud, L. Mineur, J. Desramé, B. Chibaudel, A. de Reyniès, T. André, P. Laurent-Puig, J. Taieb   +13 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Growing Molecular Plant Sciences

, 2014
The VT Molecular Plant Sciences Magazine features the work of scientists and students in the department who use molecular approaches to unravel the mysteries of ...
Molecular Plant Sciences, Fralin Life Sciences Institute   +1 more
core  

Empipe™ User’s Manual Version 4.0 -- UNIX

, 1997
Empipe is a powerful and friendly software system for automated electromagnetic (EM) design optimization, driving the EM simulator em. Empipe allows you to designate geometrical and material parameters as candidate variables for optimization in an ...
Bandler, John W., Biernacki, R.M., Chen, S.H., Optimization Systems Associates   +3 more
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Generative model based on junction tree variational autoencoder for HOMO value prediction and molecular optimization. [PDF]

J Cheminform, 2023
Kondratyev V, Dryzhakov M, Gimadiev T, Slutskiy D.   +3 more
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Constrained Molecular Dynamics as a Search

, 2004
In this paper we consider a new class of search and optimization algorithms inspired by molecular dynamics simulations in ...
And Optimization Tool, Riccardo Poli, Christopher R. Stephens   +2 more
core