Results 81 to 90 of about 5,401,847 (247)

Multicriteria Optimization in a Typical Multi-Isle Warehouse with Multiple Racks

, 2014
14 páginasThis paper considers two common problems frequently found in warehouses: slotting and picking. The former refers to the best arrangement of items in the warehouse, while the latter concerns the definition of the best route to pick up the ...
Ramirez Rios, Diana G., Jairo R. Montoya-Torres, Manotas Romero, Laura P., Diana G. Ramirez-Rios, Montoya Torres, Jairo Rafael, Laura P. Manotas Romero   +5 more
core   +1 more source

3D-EDiffMG: 3D equivariant diffusion-driven molecular generation to accelerate drug discovery

Journal of Pharmaceutical Analysis
Structural optimization of lead compounds is a crucial step in drug discovery. One optimization strategy is to modify the molecular structure of a scaffold to improve both its biological activities and absorption, distribution, metabolism, excretion, and
Chao Xu, Runduo Liu, Yufen Yao, Wanyi Huang, Zhe Li, Hai-Bin Luo   +5 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Molecule discovery and optimization via evolutionary swarm intelligence

Scientific Reports
Since the advent of computational analysis and visualization of chemical compounds, Computer-Aided Drug Design has made significant contributions to drug discovery.
Hsin-Ping Liu, Frederick Kin Hing Phoa, Saykat Dutta   +2 more
doaj   +1 more source

Structural optimization method of carbon nanomaterials by introducing defects

Nihon Kikai Gakkai ronbunshu, 2017
Because of their superior mechanical, structural, and electronic properties, carbon nanomaterials (CNs) (e.g. graphene sheets and carbon nanotubes) are supposed to be base materials for nanoelectromechanical systems (NEMS).
Jin-Xing SHI, Keiichiro OHMURA, Masatoshi SHIMODA   +2 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Recent Advances in Electrochemically Mediated Reactions of Diselenides

SynOpen, 2023
Lei Zhan, Qian Wang, Hai-Tao Tang, Zu-Yu Mo, Ying-Ming Pan   +4 more
doaj   +1 more source

Prediction of intrinsic solubility for drug-like organic compounds using automated network optimizer (ANO) for physicochemical feature and hyperparameter optimization

Journal of Cheminformatics
Accurate prediction of aqueous solubility remains a critical challenge in the chemical and pharmaceutical industries, significantly influencing drug development and delivery.
You Kyoung Chung, Seung Jin Lee, Junho Lee, Himchanvit Cho, Sung-Jin Kim, Joonsuk Huh   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source