Results 71 to 80 of about 1,727,695 (209)

Cell death and life in cancer: mathematical modeling of cell fate decisions

, 2011
Tumor development is characterized by a compromised balance between cell life and death decision mechanisms, which are tighly regulated in normal cells.
Barillot, Emmanuel, Calzone, Laurence, Fourquet, Simon, Tournier, Laurent, Zinovyev, Andrei   +4 more
core   +2 more sources

The metastasis inducer CCN1 (CYR61) activates the fatty acid synthase (FASN)-driven lipogenic phenotype in breast cancer cells [PDF]

, 2016
The angiogenic inducer CCN1 (Cysteine-rich 61, CYR61) is differentially activated in metastatic breast carcinomas. However, little is known about the precise mechanisms that underlie the pro-metastatic actions of CCN1. Here, we investigated the impact of
Espinoza, Ingrid, Lupu, Ruth, Menendez, Javier A., Vellón, Luciano   +3 more
core   +1 more source

Adaptive evolution of molecular phenotypes

Journal of Statistical Mechanics: Theory and Experiment, 2014
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Held, Torsten, Nourmohammad, Armita, Lässig, Michael   +2 more
openaire   +3 more sources

Molecular Defects Underlying the Kell Null Phenotype [PDF]

Journal of Biological Chemistry, 2001
Expression of the Kell blood group system is dependent on two proteins, Kell and XK, that are linked by a single disulfide bond. Kell, a type II membrane glycoprotein, is a zinc endopeptidase, while XK, which has 10 transmembrane domains, is a putative membrane transporter.
S, Lee, D C, Russo, A P, Reiner, J H, Lee, M Y, Sy, M J, Telen, W J, Judd, P, Simon, M J, Rodrigues, T, Chabert, J, Poole, S, Jovanovic-Srzentic, C, Levene, V, Yahalom, C M, Redman   +14 more
openaire   +2 more sources

Substitutions in the redox-sensing PAS domain of the NifL regulatory protein define an inter-subunit pathway for redox signal transmission [PDF]

, 2011
The Per-ARNT-Sim (PAS) domain is a conserved a/ß fold present within a plethora of signalling proteins from all kingdoms of life. PAS domains are often dimeric and act as versatile sensory and interaction modules to propagate environmental signals to ...
Ayers, Campbell, Demeler, Dixon, Hefti, Hill, Karimova, Key, Kurokawa, Little, Little, Little, Ma, Macheroux, Martinez-Argudo, Matthews, Miyatake, Money, Möglich, Möglich, Möglich, Nan, Perry, Qi, Reyes-Ramirez, Reyes-Ramirez, Slavny, Söderbäck, Taylor, Ukaegbu, Watts, Williamson, Zhou, Zoltowski, Zoltowski   +34 more
core   +1 more source

Thalassemia intermedia phenotype resulting from rare combination of c.46delT [Codon15 (‐T)] mutation of beta globin gene and HPFH3

Clinical Case Reports, 2017
Key Clinical Message The beta thalassemia intermedia phenotype has several genotypes. Hematological and molecular diagnostic approach and logical and sequential conduct of various investigations are necessary for the diagnosis of these disorders.
Anjali J. Kelkar, Anu Moses
doaj   +1 more source

Macromolecular crowding explains overflow metabolism in cells [PDF]

, 2016
Overflow metabolism is a metabolic phenotype of cells characterized by mixed oxidative phosphorylation (OxPhos) and fermentative glycolysis in the presence of oxygen.
Oltvai, Zoltán N., Vazquez, Alexei
core   +1 more source

Molecular Mechanisms Modulating the Phenotype of Macrophages and Microglia

Frontiers in Immunology, 2017
Macrophages and microglia play crucial roles during central nervous system development, homeostasis and acute events such as infection or injury. The diverse functions of tissue macrophages and microglia are mirrored by equally diverse phenotypes.
Stephanie A. Amici, Joycelyn Dong, Joycelyn Dong, Mireia Guerau-de-Arellano, Mireia Guerau-de-Arellano, Mireia Guerau-de-Arellano, Mireia Guerau-de-Arellano   +6 more
doaj   +1 more source

A method for estimating coherence of molecular mechanisms in major human disease and traits

BMC Bioinformatics, 2020
Background Phenotypes such as height and intelligence, are thought to be a product of the collective effects of multiple phenotype-associated genes and interactions among their protein products.
Mikhail G. Dozmorov, Kellen G. Cresswell, Silviu-Alin Bacanu, Carl Craver, Mark Reimers, Kenneth S. Kendler   +5 more
doaj   +1 more source

Key role of MEK/ERK pathway in sustaining tumorigenicity and in vitro radioresistance of embryonal rhabdomyosarcoma stem-like cell population [PDF]

, 2016
The identification of signaling pathways that affect the cancer stem-like phenotype may provide insights into therapeutic targets for combating embryonal rhabdomyosarcoma.
Ciccarelli, Carmela, DI PAOLO, Virginia, Giampaolo, Adele, Gravina, GIOVANNI LUCA, Hassan, Hamisa Jane, Macioce, Giampiero, Marampon, Francesco, Milazzo, Luisa, Tombolini, Vincenzo, Vulcano, Francesca, Zani, Bianca Maria   +10 more
core   +9 more sources